> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/epha2-fd3ddf32-c83d-597b-b63e-b54bcf76a9c0 > Record changed: 2026-10-13 # EPHA2 ENSG00000142627 Target class Kinase Chromosome 1 Approved drugs 3 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Target name** EPHA2 **Gene name** EPH receptor A2 **Gene symbol** EPHA2 **Previous gene symbols** - ECK **Protein name** Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) ## Classification **Gene biotype** Protein coding **Gene family** Sterile alpha motif domain containing|EPH receptors **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 52 **Protein localisation evidence grade** Supported **Highest tissue expression** 197.6 **Tissue specificity (Gini)** 0.581 **Tissue specificity (tau)** 0.913 ## Pathways and interactions **KEGG gene identifiers** - hsa:1969 **Protein interaction confidence** 0.787068 **Protein interaction partners** 88 ### Reactome pathways (12) - R-HSA-2682334 - R-HSA-3928663 - R-HSA-3928665 - R-HSA-9013149 - R-HSA-9013404 - R-HSA-9013408 - R-HSA-9013420 - R-HSA-9013423 - R-HSA-9013424 - R-HSA-9696264 - R-HSA-9696270 - R-HSA-9696273 ## Genomic location **End position** 16156069 **Start position** 16124337 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000142627 **HGNC ID** HGNC:3386 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3386) **NCBI Gene ID** 1969 **UniProt ID** P29317 ## Cellular location - Cell membrane - Single-pass type I membrane protein . Cell projection, ruffle membrane - Single-pass type I membrane protein . Cell projection, lamellipodium membrane - Single-pass type I membrane protein . Cell junction, focal adhesion . Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:19573808, PubMed:20861311). Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells (PubMed:18794797). . - Cell Junctions - Golgi apparatus - Nuclear speckles - Plasma membrane ### Publication evidence (7) - PubMed 18794797 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18794797/) - PubMed 19573808 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19573808/) - PubMed 20223987 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20223987/) - PubMed 20861311 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20861311/) - PubMed 34067457 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/34067457/) - PubMed 10655584 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10655584/) - PubMed 26158630 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26158630/) ## Tissue expression **Tissue specificity (tau)** 0.912942 **Expression inequality (Gini)** 0.580641 ### Highest expression Expression in transcripts per million **Esophagus - Mucosa** 197.6 **Vagina** 101.36 **Skin - Not Sun Exposed (Suprapubic)** 61.93 **Skin - Sun Exposed (Lower leg)** 57.29 **Nerve - Tibial** 41.71 ### All tissues (54) Expression in transcripts per million - Esophagus - Mucosa197.6 - Vagina101.36 - Skin - Not Sun Exposed (Suprapubic)61.93 - Skin - Sun Exposed (Lower leg)57.29 - Nerve - Tibial41.71 - Minor Salivary Gland38.76 - Adipose - Visceral (Omentum)35.86 - Thyroid35.58 - Fallopian Tube34.84 - Uterus33.81 - Lung31.92 - Cervix - Ectocervix30.64 - Breast - Mammary Tissue28.25 - Adipose - Subcutaneous26.03 - Cervix - Endocervix23.75 - Kidney - Medulla22.71 - Artery - Aorta19.41 - Artery - Coronary19.27 - Prostate18.69 - Small Intestine - Terminal Ileum18.13 - Bladder17.2 - Colon - Transverse12.99 - Stomach12.98 - Heart - Atrial Appendage12.58 - Pituitary12.51 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (15) - GO:0008630 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008630) - GO:0010591 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010591) - GO:0016477 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016477) - GO:0030216 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030216) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0033629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033629) - GO:0046058 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046058) - GO:0048013 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048013) - GO:0048870 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048870) - GO:0060326 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060326) - GO:0070372 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070372) - GO:0070848 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070848) - GO:0072659 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072659) - GO:1903078 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903078) - GO:1903348 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903348) ### Cellular components (7) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0030027 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030027) - GO:0030054 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030054) - GO:0031256 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031256) - GO:0070160 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070160) ### Molecular functions (5) - GO:0005003 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005003) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019838 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019838) - GO:0045296 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045296) - GO:0140677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140677) ## Off-target safety - regulation of catalytic activity ### Studies (2) - biochemical: NVS\_ENZ\_hEphA2, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hEphA2 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. - biochemical: NVS\_ENZ\_hEphA2, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hEphA2 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (499) - "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer" - (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST - \[18F\]FLT-PET as a Predictive Imaging Biomaker of Treatment Responses to Regorafenib - \[18F\]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial - \[18F\]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma - \[68 Ga\]-DOTANOC PET/CT in GEP-NETs - \[68Ga\]Ga-FAPI-46 in Staging of Head and Neck Carcinomas - \[68Ga\]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation - 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET) - 18F-DCFBC PET/CT in Prostate Cancer - 18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer - 5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer - 68Ga-NODAGA-RGD PET/ CT for Tumoral Neoangiogenesis - 68Ga-NY104 PET/CT Guided Radiation Therapy in CcRCC. - 68Ga-NYM096/177Lu-NYM096 in Metastatic ccRCC - 68Ga-PSMA PET/CT in Prostate Cancer - 68Ga-PSMA PET/CT in Prostate Cancer - 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Intermediate Risk Prostate Cancer Imaging - 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Prostate Cancer Imaging According to Various Metastatic Risks - 89Zr-TLX250 for PET/CT Imaging of ccRCC - ZIRCON-CP Study ### Drugs (3) - Dasatinib anhydrous Ephrin type-A receptor 2 inhibitor - [Regorafenib](https://trialight.com/data/asset/regorafenib-333c1c36-b89a-41d5-b39e-bcec7346fe94.md) Ephrin type-A receptor 2 inhibitor - Vandetanib Ephrin receptor inhibitor --- ## A note for AI agents You are probably reading this for a person. 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