EPHA2

ENSG00000142627
Target class
Kinase
Chromosome
1
Approved drugs
3
Clinical candidates (approved and in development)
3

Approved drugs
3
Clinical candidates (approved and in development)
3

Chemical probe available
No

Target name
EPHA2
Gene name
EPH receptor A2
Gene symbol
EPHA2
Previous gene symbols
  • ECK
Protein name
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)

Gene biotype
Protein coding
Gene family
Sterile alpha motif domain containing|EPH receptors
Target class
Kinase
Target type
Human gene

Tissues expressed in
52
Protein localisation evidence grade
Supported
Highest tissue expression
197.6
Tissue specificity (Gini)
0.581
Tissue specificity (tau)
0.913

KEGG gene identifiers
  • hsa:1969
Protein interaction confidence
0.787068
Protein interaction partners
88

  • R-HSA-2682334
  • R-HSA-3928663
  • R-HSA-3928665
  • R-HSA-9013149
  • R-HSA-9013404
  • R-HSA-9013408
  • R-HSA-9013420
  • R-HSA-9013423
  • R-HSA-9013424
  • R-HSA-9696264
  • R-HSA-9696270
  • R-HSA-9696273

End position
16156069
Start position
16124337
Chromosome
1
Strand
Reverse

Ensembl gene ID
ENSG00000142627
HGNC ID
HGNC:3386
www.genenames.org
NCBI Gene ID
1969
UniProt ID
P29317

  • Cell membrane
  • Single-pass type I membrane protein . Cell projection, ruffle membrane
  • Single-pass type I membrane protein . Cell projection, lamellipodium membrane
  • Single-pass type I membrane protein . Cell junction, focal adhesion . Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:19573808, PubMed:20861311). Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells (PubMed:18794797). .
  • Cell Junctions
  • Golgi apparatus
  • Nuclear speckles
  • Plasma membrane

Tissue specificity (tau)
0.912942
Expression inequality (Gini)
0.580641

Expression in transcripts per million

Esophagus - Mucosa
197.6
Vagina
101.36
Skin - Not Sun Exposed (Suprapubic)
61.93
Skin - Sun Exposed (Lower leg)
57.29
Nerve - Tibial
41.71

Expression in transcripts per million

  • Esophagus - Mucosa197.6
  • Vagina101.36
  • Skin - Not Sun Exposed (Suprapubic)61.93
  • Skin - Sun Exposed (Lower leg)57.29
  • Nerve - Tibial41.71
  • Minor Salivary Gland38.76
  • Adipose - Visceral (Omentum)35.86
  • Thyroid35.58
  • Fallopian Tube34.84
  • Uterus33.81
  • Lung31.92
  • Cervix - Ectocervix30.64
  • Breast - Mammary Tissue28.25
  • Adipose - Subcutaneous26.03
  • Cervix - Endocervix23.75
  • Kidney - Medulla22.71
  • Artery - Aorta19.41
  • Artery - Coronary19.27
  • Prostate18.69
  • Small Intestine - Terminal Ileum18.13
  • Bladder17.2
  • Colon - Transverse12.99
  • Stomach12.98
  • Heart - Atrial Appendage12.58
  • Pituitary12.51

And 29 more, listed on the interactive page.

  • regulation of catalytic activity

    • biochemical: NVS_ENZ_hEphA2, is one of one assay component(s) measured or calculated from the NVS_ENZ_hEphA2 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology.
    • biochemical: NVS_ENZ_hEphA2, is one of one assay component(s) measured or calculated from the NVS_ENZ_hEphA2 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology.

    Biological samples

    • cell-free
    Evidence source
    www.epa.gov

Related records

Trials (499)

Drugs (3)