> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/epas1-79d84ab7-177d-56f7-bc0e-cd19facb5526
> Record changed: 2026-10-13

# EPAS1

ENSG00000116016

Target class

Transcription factor

Chromosome

2

Approved drugs

1

Clinical candidates (approved and in development)

1

## Clinical evidence

**Approved drugs**

1

**Clinical candidates (approved and in development)**

1

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

EPAS1

**Gene name**

Endothelial PAS domain protein 1

**Gene symbol**

EPAS1

**Protein name**

Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)

### Other names (5)

- MOP2
- PASD2
- HIF2A
- HLF
- bHLHe73

## Classification

**Gene biotype**

Protein coding

**Gene family**

Basic helix-loop-helix proteins|PAS domain containing

**Target class**

Transcription factor

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

1,031.42

**Tissue specificity (Gini)**

0.523

**Tissue specificity (tau)**

0.878

## Pathways and interactions

**KEGG gene identifiers**

- hsa:2034

**Protein interaction confidence**

0.868981

**Protein interaction partners**

52

### Reactome pathways (8)

- R-HSA-1234158
- R-HSA-1234174
- R-HSA-1234176
- R-HSA-452723
- R-HSA-8849473
- R-HSA-8951664
- R-HSA-9664873
- R-HSA-9909649

## Genomic location

**End position**

46386697

**Start position**

46293667

**Chromosome**

2

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000116016

**HGNC ID**

HGNC:3374

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3374)

**NCBI Gene ID**

2034

**UniProt ID**

Q99814

## Cellular location

- Nucleus . Nucleus speckle . Note=Colocalizes with HIF3A in the nucleus and speckles. .
- Nucleoplasm

## Tissue expression

**Tissue specificity (tau)**

0.878258

**Expression inequality (Gini)**

0.523279

### Highest expression

Expression in transcripts per million

**Lung**

1,031.42

**Artery - Tibial**

566.46

**Artery - Coronary**

473.56

**Adipose - Subcutaneous**

424.79

**Artery - Aorta**

404.45

### All tissues (54)

Expression in transcripts per million

- Lung1,031.42
- Artery - Tibial566.46
- Artery - Coronary473.56
- Adipose - Subcutaneous424.79
- Artery - Aorta404.45
- Adipose - Visceral (Omentum)402.52
- Thyroid350.42
- Breast - Mammary Tissue325
- Fallopian Tube242.72
- Uterus204.89
- Bladder157.32
- Cervix - Endocervix156.04
- Nerve - Tibial155.55
- Cervix - Ectocervix144.65
- Prostate140.46
- Cells - Cultured fibroblasts137.25
- Kidney - Medulla126.26
- Heart - Atrial Appendage114.23
- Kidney - Cortex112.86
- Esophagus - Muscularis107.81
- Esophagus - Gastroesophageal Junction106.52
- Vagina99.17
- Spleen96.1
- Small Intestine - Terminal Ileum95.28
- Skin - Sun Exposed (Lower leg)89.52

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (5)

- GO:0001666  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001666)
- GO:0007165  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165)
- GO:0045944  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944)
- GO:0071456  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071456)
- GO:2000434  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000434)

### Cellular components (3)

- GO:0005654  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654)
- GO:0005667  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005667)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)

### Molecular functions (5)

- GO:0001223  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001223)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0043565  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043565)
- GO:0046982  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046982)
- GO:0061629  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061629)

## Related records

### Trials (37)

- A Clinical Study of Belzutifan (MK-6482) Alone or With Phenytoin in Healthy Participants (CA46602/MK-6482-035)
- A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034)
- A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)
- A Food Effect Study in Healthy Volunteers With Belzutifan (PT2977, MK-6482) Tablets
- A Phase 2 Study of Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004)
- A Study of Belzutifan (MK-6482) and Metformin in Healthy Adult Participants (MK-6482-039)
- A Study of Belzutifan (MK-6482) as Monotherapy and in Combination With Lenvatinib (E7080/MK-7902) With or Without Pembrolizumab (MK-3475) in China Participants With Advanced Renal Cell Carcinoma (MK-6482-010)
- A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)
- A Study of Belzutifan (MK-6482) in Combination With Palbociclib Versus Belzutifan Monotherapy in Participants With Advanced Renal Cell Carcinoma (MK-6482-024/LITESPARK-024)
- A Study of Belzutifan (MK-6482) in Participants With Advanced Clear Cell Renal Cell Carcinoma (MK-6482-018)
- A Study of Belzutifan (MK-6482) in Participants With Advanced Renal Cell Carcinoma (MK-6482-013)
- A Study of Belzutifan (MK-6482) in Participants With Hepatic Impairment (MK-6482-020)
- A Study of Belzutifan (MK-6482) in Participants With Renal Impairment (MK-6482-021)
- [A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)](https://trialight.com/data/trial/a-study-of-belzutifan-mk-6482-plus-pembrolizumab-mk-3475-f9e2ee9a-1ecf-4dbb-ba7d-7872d292ab8b.md)
- A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)
- A Study of Belzutifan in Adolescent Participants With Solid Tumors (MK-9999-01E/LIGHTBEAM-U01)
- A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma
- A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)
- A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, vs Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)-China Extension Study
- A Trial of Belzutifan (PT2977, MK-6482) in Combination With Cabozantinib in Patients With Clear Cell Renal Cell Carcinoma (ccRCC) (MK-6482-003)

### Drugs (1)

- [Belzutifan](https://trialight.com/data/asset/belzutifan-2287c89c-8beb-4a1c-a6de-f8d6dfb3499b.md) Endothelial PAS domain-containing protein 1 inhibitor

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