> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/egfr-5c134fbe-bf90-5792-81e3-542be53c2be7 > Record changed: 2026-10-13 # EGFR ENSG00000146648 Target class Kinase Chromosome 7 Approved drugs 21 Clinical candidates (approved and in development) 80 ## Clinical evidence **Approved drugs** 21 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 80 ## Druggability **Chemical probe available** Yes ## Names **Target name** EGFR **Gene name** Epidermal growth factor receptor **Gene symbol** EGFR **Previous gene symbols** - ERBB **Protein name** Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) ### Other names (2) - ERBB1 - ERRP ## Classification **Gene biotype** Protein coding **Gene family** Erb-b2 receptor tyrosine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 52 **Protein localisation evidence grade** Supported **Highest tissue expression** 78.34 **Tissue specificity (Gini)** 0.474 **Tissue specificity (tau)** 0.77 ## Pathways and interactions **KEGG gene identifiers** - hsa:1956 **Protein interaction confidence** 0.845447 **Protein interaction partners** 490 ### Reactome pathways (37) - R-HSA-1227986 - R-HSA-1236382 - R-HSA-1236394 - R-HSA-1250196 - R-HSA-1251932 - R-HSA-1257604 - R-HSA-177929 - R-HSA-179812 - R-HSA-180292 - R-HSA-180336 - R-HSA-182971 - R-HSA-1963640 - R-HSA-1963642 - R-HSA-212718 - R-HSA-2179392 - R-HSA-2219530 - R-HSA-445144 - R-HSA-5637810 - R-HSA-5638303 - R-HSA-5673001 - R-HSA-6785631 - R-HSA-6811558 - R-HSA-8847993 - R-HSA-8856825 - R-HSA-8856828 And 12 more, listed on the interactive page. ## Genomic location **End position** 55211628 **Start position** 55018820 **Chromosome** 7 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000146648 **HGNC ID** HGNC:3236 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3236) **NCBI Gene ID** 1956 **UniProt ID** P00533 ## Cellular location - Cell membrane - Single-pass type I membrane protein . Endoplasmic reticulum membrane - Single-pass type I membrane protein. Golgi apparatus membrane - Single-pass type I membrane protein. Nucleus membrane - Single-pass type I membrane protein. Endosome . Endosome membrane. Nucleus . Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:17909029, PubMed:20674546). Endocytosed upon activation by ligand (PubMed:17182860, PubMed:17909029, PubMed:27153536, PubMed:2790960). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). . - SUBCELLULAR LOCATION: \[Isoform 2\]: Secreted. - Cell Junctions - End piece - Golgi apparatus - Mid piece - Plasma membrane - Principal piece ### Publication evidence (11) - PubMed 17182860 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17182860/) - PubMed 20462955 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20462955/) - PubMed 23589287 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23589287/) - PubMed 26918609 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26918609/) - PubMed 27153536 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27153536/) - PubMed 2790960 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2790960/) - PubMed 35538033 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35538033/) - PubMed 17115032 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17115032/) - PubMed 17909029 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17909029/) - PubMed 20551055 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20551055/) - PubMed 20674546 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20674546/) ## Tissue expression **Tissue specificity (tau)** 0.770495 **Expression inequality (Gini)** 0.474198 ### Highest expression Expression in transcripts per million **Skin - Sun Exposed (Lower leg)** 78.34 **Skin - Not Sun Exposed (Suprapubic)** 75.93 **Cells - Cultured fibroblasts** 60.63 **Nerve - Tibial** 43.12 **Vagina** 40.6 ### All tissues (54) Expression in transcripts per million - Skin - Sun Exposed (Lower leg)78.34 - Skin - Not Sun Exposed (Suprapubic)75.93 - Cells - Cultured fibroblasts60.63 - Nerve - Tibial43.12 - Vagina40.6 - Adipose - Subcutaneous39.73 - Esophagus - Gastroesophageal Junction34.63 - Artery - Tibial33.2 - Breast - Mammary Tissue32.94 - Esophagus - Muscularis31.8 - Minor Salivary Gland31.63 - Cervix - Ectocervix30.95 - Esophagus - Mucosa29.91 - Fallopian Tube28.12 - Prostate27.05 - Adipose - Visceral (Omentum)25.84 - Thyroid25.04 - Cervix - Endocervix24.72 - Bladder23.53 - Artery - Aorta23.45 - Lung22.13 - Uterus21.4 - Ovary20.74 - Artery - Coronary20.18 - Colon - Sigmoid18.98 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (33) - GO:0001934 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001934) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166) - GO:0007173 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007173) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0030307 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030307) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0033138 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033138) - GO:0034165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034165) - GO:0038134 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038134) - GO:0042059 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042059) - GO:0042177 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042177) - GO:0042327 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042327) - GO:0043066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066) - GO:0043410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410) - GO:0043491 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043491) - GO:0045739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045739) - GO:0045740 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045740) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) - GO:0050679 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050679) - GO:0050730 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050730) - GO:0051205 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051205) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) - GO:0070141 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070141) - GO:0070374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070374) And 8 more, listed on the interactive page. ### Cellular components (21) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005768 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0010008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0016323 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016323) - GO:0030054 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030054) - GO:0030669 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030669) - GO:0031901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031901) - GO:0032587 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032587) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) - GO:0045121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045121) - GO:0048471 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471) - GO:0097489 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097489) - GO:0097708 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097708) ### Molecular functions (14) - GO:0003682 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003682) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004714) - GO:0004888 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004888) - GO:0005006 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005006) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0019900 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019900) - GO:0019903 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019903) - GO:0030296 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030296) - GO:0031625 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031625) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0045296 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045296) - GO:0051015 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051015) ## On-target safety - alopecia ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - cardiomyopathy ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Hepatotoxicity ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - liver PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Skin rash ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - skin PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - diarrhoea ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - GI PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - epithelial inflammation ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - AST increase ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - liver PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - ocular keratitis ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - ocular PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - weight loss ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - interstitial lung disease ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - respiratory PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - heart disease ### Studies - preclinical: Important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: Helps to maintain left ventricular function in setting of chronic catecholamine stimulation; mediates pro-survival signalling ### Biological samples - cardiovascular system PubMed 21283106 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21283106/) - decreased appetite ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - ALT increase ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - liver PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - hypertension ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ENZ\_hEGFR, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hEGFR assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (4,080) - -02341066 and PF-00299804 for Advanced Non-Small Cell Lung Cancer - (89Zr Panitumumab) With PET/CT for Diagnosing Metastases in Patients With Head and Neck Squamous Cell Carcinoma - (HARMONY) Study of BLU-701 in EGFR-mutant NSCLC - (SYMPHONY) Phase 1/2 Study Targeting EGFR Resistance Mechanisms in NSCLC - 18F-FDG PET and Osimertinib in Evaluating Glucose Utilization in Patients with EGFR Activated Recurrent Glioblastoma - 18F-FDG Uptake Heterogeneity Predicts Pyrotinib Response - 2nd Line Erlotinib Treatment With (Out) Chemotherapy of Advanced Non Small Cell Lung Cancer (NSCLC) - 3'-Deoxy-3'-\[18F\] Fluorothymidine and Fludeoxyglucose F 18 PET Scans in Evaluating Response to Cetuximab, Cisplatin, and Radiation Therapy in Patients With Advanced Cancer of the Oropharynx, Larynx, or Hypopharynx - 5-fluorouracil Plus Panitumumab (Anti-EGFR) and Sotorasib (KRAS G12C Inhibitor) in First-line Treatment of Patients Non-eligible for a Doublet/Triplet Chemotherapy With Advanced Unresectab - 5-FU Based Maintenance Therapy in RAS Wild Type Metastatic Colorectal Cancer After Induction With FOLFOX Plus Panitumumab - 5-FU, Folinic Acid and Irinotecan (FOLFIRI) Plus Cetuximab Versus FOLFIRI Plus Bevacizumab in First Line Treatment Colorectal Cancer (CRC) - 5G-EMERALD: Amivantamab in Malignant Brain Tumours - 6 Weeks Treatment of Locally Advanced Breast Cancer With BIBW 2992 (Afatinib) or Lapatinib or Trastuzumab - 7 Day's of Erlotinib Neo-adjuvant, Followed by Adjuvant Erlotinib-gemcitabine in Pancreatic Cancer Patients - 89Zr-Panitumumab for Assessment of Suspected Metastatic Lesions on 18F-FDG-PET/CT in HNSCC - A 1-year Multi-center, Prospective, Cohort Study in Patients With Chronic Obstructive Pulmonary Disease Treated With Long-acting Bronchodilator - A Biomarker Identification Trial of Tarceva (Erlotinib) in Patients With Advanced Pancreatic Cancer - A Biomarker-implemented Clinical Study Evaluating Mutations in MET and TP53 in a Population of Treatment-refractory Squamous Cell Carcinoma - A Chinese Randomized Crossover Study of Erlotinib Versus Docetaxel/Cisplatin in Previously Untreated Stage IIIB/IV Lung Adenocarcinoma With EGFR Mutations - A Clinica Study of Pyrotinib in Patients of Advanced Non-Small Cell Lung Cancer With HER2 Mutation ### Drugs (87) - Abivertinib Epidermal growth factor receptor erbB1 inhibitor - Abivertinib maleate Epidermal growth factor receptor erbB1 inhibitor - AC-480 Epidermal growth factor receptor erbB1 inhibitor - AEE-788 Epidermal growth factor receptor erbB1 inhibitor - Afatinib Epidermal growth factor receptor erbB1 inhibitor - Afatinib dimaleate Epidermal growth factor receptor erbB1 inhibitor - Allitinib Epidermal growth factor receptor erbB1 inhibitor - [Amivantamab](https://trialight.com/data/asset/amivantamab-94d99890-d90e-4d89-8a02-036a29458456.md) Epidermal growth factor receptor erbB1 inhibitor - [Aumolertinib](https://trialight.com/data/asset/aumolertinib-1339ec2f-ba43-4359-aaa7-6a9516518faa.md) Epidermal growth factor receptor erbB1 inhibitor - AV-412 Epidermal growth factor receptor erbB1 inhibitor - AV-412 FREE BASE Epidermal growth factor receptor erbB1 inhibitor - AZD-3759 Epidermal growth factor receptor erbB1 inhibitor - AZD-4769 Epidermal growth factor receptor erbB1 inhibitor - Bafisontamab Epidermal growth factor receptor erbB1 inhibitor - BMS-690514 Epidermal growth factor receptor erbB1 inhibitor - Brigatinib Epidermal growth factor receptor erbB1 inhibitor - Canertinib Epidermal growth factor receptor erbB1 inhibitor - Canertinib dihydrochloride Epidermal growth factor receptor erbB1 inhibitor - CEP-32496 Epidermal growth factor receptor erbB1 inhibitor - [Cetuximab](https://trialight.com/data/asset/cetuximab-a1f8c65c-bae1-4b77-9491-dca37aeeaa3c.md) Epidermal growth factor receptor erbB1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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