> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ednrb-da75faab-e287-523c-a987-31a96198df30
> Record changed: 2026-11-04

# EDNRB

ENSG00000136160

Target class

GPCR

Chromosome

13

Approved drugs

6

Clinical candidates (approved and in development)

10

## Clinical evidence

**Approved drugs**

6

**ClinGen gene-disease validity**

Moderate

**Clinical candidates (approved and in development)**

10

## Druggability

**Chemical probe available**

Yes

## Names

**Other names**

- ETB

**Target name**

EDNRB

**Gene name**

Endothelin receptor type B

**Gene symbol**

EDNRB

**Protein name**

Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type)

### Previous gene symbols (2)

- HSCR2
- HSCR

## Classification

**Gene biotype**

Protein coding

**Gene family**

Endothelin receptors

**Target class**

GPCR

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

52

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

73.2

**Tissue specificity (Gini)**

0.411

**Tissue specificity (tau)**

0.742

## Pathways and interactions

**KEGG gene identifiers**

- hsa:1910

**Protein interaction confidence**

0.874643

**Protein interaction partners**

28

### Reactome pathways (3)

- R-HSA-375276
- R-HSA-416476
- R-HSA-9856649

## Genomic location

**End position**

77975529

**Start position**

77895481

**Chromosome**

13

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000136160

**HGNC ID**

HGNC:3180

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3180)

**NCBI Gene ID**

1910

**UniProt ID**

P24530

## Cellular location

- Cell membrane
- Multi-pass membrane protein. Note=internalized after activation by endothelins. .
- Plasma membrane

### Publication evidence

- PubMed 28236341  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28236341/)

## Tissue expression

**Tissue specificity (tau)**

0.741883

**Expression inequality (Gini)**

0.41083

### Highest expression

Expression in transcripts per million

**Adipose - Visceral (Omentum)**

73.2

**Lung**

65.38

**Adipose - Subcutaneous**

60.64

**Brain - Caudate (basal ganglia)**

48.83

**Breast - Mammary Tissue**

45.49

### All tissues (54)

Expression in transcripts per million

- Adipose - Visceral (Omentum)73.2
- Lung65.38
- Adipose - Subcutaneous60.64
- Brain - Caudate (basal ganglia)48.83
- Breast - Mammary Tissue45.49
- Thyroid42.37
- Brain - Nucleus accumbens (basal ganglia)39.43
- Brain - Putamen (basal ganglia)35.77
- Cervix - Ectocervix31.63
- Brain - Substantia nigra31.21
- Brain - Amygdala28.4
- Fallopian Tube26.18
- Brain - Anterior cingulate cortex (BA24)25.76
- Adrenal Gland24.85
- Brain - Hypothalamus23.82
- Kidney - Medulla23.2
- Nerve - Tibial22.78
- Vagina22.2
- Bladder21.86
- Prostate21.47
- Uterus20.59
- Heart - Atrial Appendage19.93
- Cervix - Endocervix19.63
- Esophagus - Muscularis16.71
- Brain - Frontal Cortex (BA9)16.04

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (11)

- GO:0000122  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122)
- GO:0007166  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166)
- GO:0007194  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007194)
- GO:0007200  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007200)
- GO:0007399  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007399)
- GO:0014826  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014826)
- GO:0019722  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019722)
- GO:0042310  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042310)
- GO:0048246  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048246)
- GO:0051248  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051248)
- GO:0086100  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086100)

### Cellular components

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)

### Molecular functions (3)

- GO:0004962  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004962)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0017046  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017046)

## On-target safety

- decreased intestinal transit  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased intestinal transit  
### Biological samples (5)

  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased gastric emptying  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased gastric emptying  
### Biological samples (5)

  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- cardiovascular malformations  
### Effects

  - Inhibition/Decrease/Downregulation: developmental toxicity  
### Studies

  - preclinical: cardiovascular malformations  
### Biological samples (5)

  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased then decreased heart rate  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased then decreased heart rate  
### Biological samples (5)

  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased urine excretion  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased urine excretion  
### Biological samples (5)

  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased pain  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased pain  
### Biological samples (5)

  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- cell proliferation  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: cell proliferation  
### Biological samples (5)

  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- pulmonary hypertension  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: pulmonary hypertension  
### Biological samples (5)

  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased blood pressure  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased blood pressure  
### Biological samples (5)

  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- left ventricular hypertrophy  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: left ventricular hypertrophy  
### Biological samples (5)

  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased then increased blood pressure  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased then increased blood pressure  
### Biological samples (5)

  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- bronchoconstriction  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: bronchoconstriction  
### Biological samples (5)

  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased platelet aggregation  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased platelet aggregation  
### Biological samples (5)

  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- craniofacial abnormalities  
### Effects

  - Inhibition/Decrease/Downregulation: developmental toxicity  
### Studies

  - preclinical: craniofacial abnormalities  
### Biological samples (5)

  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- glomerular and tubulointerstitial structural injury  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: glomerular and tubulointerstitial structural injury  
### Biological samples (5)

  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

## Off-target safety

- receptor binding  
### Studies

  - biochemical: NVS\_GPCR\_hETB, is one of one assay component(s) measured or calculated from the NVS\_GPCR\_hETB assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology.  
### Biological samples

  - cell-free  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)

## Related records

### Trials (294)

- (ARTEMIS-IPF) Randomized, Placebo-Controlled Study to Evaluate Safety and Effectiveness of Ambrisentan in IPF
- (RIGHT HEART III Study - Right Ventricular Hemodynamic Evaluation and Response to Treatment)
- A 12 Week Safety And Efficacy Study Of Sitaxentan Sodium In Japanese Pulmonary Arterial Hypertension Patients
- A 2-part Study to Investigate the Effect of Macitentan in Healthy Male Participants
- A Clinical Study to Evaluate the Effects of Darusentan on Safety and Efficacy in Subjects With Resistant Systolic Hypertension Receiving Combination Therapy With Three or More Blood Pressure Lowering Drugs
- A Clinical Study to Find Out if Macitentan is Effective and Safe in Japanese Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH).
- A Clinical Study to Investigate the Long-term Safety of the Drug Macitentan in Patients With Pulmonary Hypertension Who Were Previously Treated With Macitentan in Clinical Studies.
- A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis
- [A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)](https://trialight.com/data/trial/a-clinical-trial-to-evaluate-mk-4208-embibatinib-in-healthy-7e3461de-b189-4af2-af82-5175294701bc.md)
- A Drug-drug Interaction Trial in Healthy Female Participants to Investigate the Effect of Aprocitentan on Combined Hormonal Contraceptives
- A Long Term Safety Study With Atrasentan
- A Long Term Study of Ambrisentan in Pulmonary Arterial Hypertension Subjects Having Completed AMB-320 (NCT00423748) or AMB-321 (NCT00423202)
- A Long Term Study to Find Out if Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease
- A Long-Term, Open-Label Study to Evaluate the Safety of Sitaxsentan Sodium Treatment in Patients With Pulmonary Arterial Hypertension
- A Non-Interventional, Patient Registry For The Collection Of Pre-Defined Safety Data In Patients Prescribed Thelin
- A Open Label Study to Assess the Long-term Safety, Tolerability and Efficacy of Ambrisentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
- A Pharmacokinetic Drug-Drug Interaction (DDI) Study Between Sitaxsentan And Sildenafil, And Between Sitaxsentan And Tadalafil After Multiple Doses
- A Phase 1 Relative Bioavailability Study of Ambrisentan and Tadalfil Fixed Dose Combination Tablets in Healthy Subjects
- A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess Safety and Efficacy of Ambrisentan in Subjects With Pulmonary Arterial Hypertension.
- A Phase I, Open-label, Ascending Dose Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the Endothelin B Agonist, SPI-1620, in Patients With Recurrent or Progressive Carcinoma

### Drugs (14)

- Ambrisentan Endothelin receptor, ET-A/ET-B antagonist
- Aprocitentan Endothelin receptor, ET-A/ET-B antagonist
- Atrasentan
- [Bosentan](https://trialight.com/data/asset/bosentan-6ef53d8d-fbe1-467b-8b1c-2a31a0578e16.md) Endothelin receptor, ET-A/ET-B antagonist
- Clazosentan
- Darusentan Endothelin receptor ET-B antagonist
- Enrasentan Endothelin receptor ET-B antagonist
- Macitentan Endothelin receptor, ET-A/ET-B antagonist
- RG-7636 Endothelin receptor ET-B binding agent
- Ro-468443
- Sitaxentan Endothelin receptor, ET-A/ET-B antagonist
- Sitaxentan sodium Endothelin receptor, ET-A/ET-B antagonist
- Sovatelitide
- Tezosentan Endothelin receptor ET-B antagonist

---

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