> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/drd4-1603d5ba-dc56-5d3c-8e50-ee3e743fd524 > Record changed: 2026-10-13 # DRD4 ENSG00000069696 Target class GPCR Chromosome 11 Approved drugs 25 Clinical candidates (approved and in development) 27 ## Clinical evidence **Approved drugs** 25 **Clinical candidates (approved and in development)** 27 ## Druggability **Chemical probe available** Yes ## Names **Target name** DRD4 **Gene name** Dopamine receptor D4 **Gene symbol** DRD4 **Protein name** D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor) ## Classification **Gene biotype** Protein coding **Gene family** Dopamine receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 44 **Protein localisation evidence grade** Uncertain **Highest tissue expression** 7.61 **Tissue specificity (Gini)** 0.383 **Tissue specificity (tau)** 0.684 ## Pathways and interactions **KEGG gene identifiers** - hsa:1815 **Protein interaction confidence** 0.785688 **Protein interaction partners** 32 ### Reactome pathways (2) - R-HSA-390651 - R-HSA-418594 ## Genomic location **End position** 640706 **Start position** 637269 **Chromosome** 11 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000069696 **HGNC ID** HGNC:3025 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3025) **NCBI Gene ID** 1815 **UniProt ID** P21917 ## Cellular location - Cell membrane - Multi-pass membrane protein . - Plasma membrane ### Publication evidence (10) - PubMed 1319557 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1319557/) - PubMed 16423344 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16423344/) - PubMed 1840645 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1840645/) - PubMed 20100572 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20100572/) - PubMed 27659709 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27659709/) - PubMed 29051383 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/29051383/) - PubMed 7512953 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7512953/) - PubMed 7643093 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7643093/) - PubMed 8078498 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8078498/) - PubMed 9003072 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9003072/) ## Tissue expression **Tissue specificity (tau)** 0.683882 **Expression inequality (Gini)** 0.38342 ### Highest expression Expression in transcripts per million **Pituitary** 7.61 **Brain - Cerebellum** 6.97 **Ovary** 6.82 **Testis** 6.33 **Brain - Cerebellar Hemisphere** 6.12 ### All tissues (54) Expression in transcripts per million - Pituitary7.61 - Brain - Cerebellum6.97 - Ovary6.82 - Testis6.33 - Brain - Cerebellar Hemisphere6.12 - Fallopian Tube5.83 - Nerve - Tibial4.4 - Cervix - Ectocervix4.28 - Uterus4.23 - Prostate4.14 - Thyroid3.83 - Cervix - Endocervix3.75 - Bladder3.27 - Esophagus - Gastroesophageal Junction3.12 - Vagina3.11 - Esophagus - Muscularis3.04 - Colon - Sigmoid2.98 - Brain - Cortex2.79 - Brain - Hypothalamus2.62 - Skin - Not Sun Exposed (Suprapubic)2.47 - Brain - Spinal cord (cervical c-1)2.38 - Brain - Nucleus accumbens (basal ganglia)2.31 - Skin - Sun Exposed (Lower leg)2.24 - Artery - Tibial2.12 - Artery - Aorta2.08 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (9) - GO:0006874 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006874) - GO:0007195 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007195) - GO:0034776 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034776) - GO:0043410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410) - GO:0048149 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048149) - GO:0050482 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050482) - GO:0050709 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050709) - GO:0051586 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051586) - GO:0060158 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060158) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (9) - GO:0001591 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001591) - GO:0004935 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004935) - GO:0004952 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004952) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0017124 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017124) - GO:0035240 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035240) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0051379 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051379) - GO:0051380 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051380) ## Off-target safety - receptor binding ### Studies - biochemical: NVS\_GPCR\_hDRD4.4, is one of one assay component(s) measured or calculated from the NVS\_GPCR\_hDRD4.4 assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (914) - "Extended" (Alternate Day) Antipsychotic Dosing - "Olanzapine for Prevention of Chemotherapy Induced Nausea and Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy (HEC)" - 12-week Polysomnography Study of Ropinirole Controlled Release for Restless Legs Syndrome - 15 Month Study for Adults Who Have Been Diagnosed With Schizophrenia and Incarcerated - 3-Week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07008) - 3-week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07009) - 40 Week Extension Study Of Asenapine and Olanzapine For Bipolar Disorder (A7501007)(COMPLETED)(P05857) - 5-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset Schizophrenia - 5HT3 Antagonism and Auditory Gating in Schizophrenia - 6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptom Patients Who Completed the Protocol 25543 (25544)(P05777) - 6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptoms Patients Who Completed the First 6- Month Trial (A7501014)(COMPLETED)(P05772) - 9 Week Extension Study of Asenapine and Olanzapine in Treatment of Mania (P07007)(COMPLETED) - A 12-week Study of Pramipexole Extended Release (ER) in Patients With Parkinson's Disease (PD), Followed by a 52-week Long-term Treatment Period - A 4-week, Randomized, Rater-blinded, Parallel Study to Evaluate Quetiapine in Improving Sleep Quality of Schizophrenia - A 6 Month Study to Compare the Metabolic Effects of Paliperidone ER and Olanzapine in Patients With Schizophrenia - A 6 Week Trial to Study the Efficacy and Safety of a Starting Dose 0.25 mg Pramipexole (Mirapex) in Patients With RLS - A Cardiac Safety Study of an Investigational Drug to See How if Affects the Heart in People With Parkinson's Disease Complicated by Motor Fluctuations "OFF" Episodes - A Clinical Research Study Evaluating Ropinirole Treatment For Restless Legs Syndrome (RLS) - A Clinical Research Study Testing Ropinirole Treatment for Restless Legs Syndrome - A Clinical Study of KDT-3594 in Patients With Early Parkinson's Disease. ### Drugs (36) - Amoxapine Dopamine receptor antagonist - Apomorphine D2-like dopamine receptor agonist - Apomorphine hydrochloride D2-like dopamine receptor agonist - Bromocriptine D2-like dopamine receptor agonist - Bromocriptine mesylate D2-like dopamine receptor agonist - Chlorpromazine D2-like dopamine receptor antagonist - Chlorpromazine hydrochloride D2-like dopamine receptor antagonist - Clothiapine Dopamine D4 receptor antagonist - Droperidol D2-like dopamine receptor antagonist - Ergoloid Dopamine receptor agonist - Ergoloid mesylates Dopamine receptor agonist - Haloperidol D2-like dopamine receptor inverse agonist - Haloperidol decanoate D2-like dopamine receptor inverse agonist - Haloperidol lactate D2-like dopamine receptor inverse agonist - Levomepromazine D2-like dopamine receptor antagonist - Loxapine D2-like dopamine receptor antagonist - Loxapine hydrochloride D2-like dopamine receptor antagonist - Loxapine succinate D2-like dopamine receptor antagonist - [Olanzapine](https://trialight.com/data/asset/olanzapine-5b966c11-69ff-43ab-aefa-6c712a56b2d4.md) D2-like dopamine receptor antagonist - Olanzapine pamoate D2-like dopamine receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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