> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/drd1-368a14c8-391b-5d59-8cde-2c48da15a9c1
> Record changed: 2026-10-13

# DRD1

ENSG00000184845

Target class

GPCR

Chromosome

5

Approved drugs

9

Clinical candidates (approved and in development)

12

## Clinical evidence

**Approved drugs**

9

**Clinical candidates (approved and in development)**

12

## Druggability

**Chemical probe available**

No

## Names

**Other names**

- D1R

**Target name**

DRD1

**Gene name**

Dopamine receptor D1

**Gene symbol**

DRD1

**Protein name**

D(1A) dopamine receptor (Dopamine D1 receptor)

## Classification

**Gene biotype**

Protein coding

**Gene family**

Dopamine receptors

**Target class**

GPCR

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

11

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

31.54

**Tissue specificity (Gini)**

0.836

**Tissue specificity (tau)**

0.949

## Pathways and interactions

**KEGG gene identifiers**

- hsa:1812

**Protein interaction confidence**

0.849677

**Protein interaction partners**

31

### Reactome pathways (2)

- R-HSA-390651
- R-HSA-418555

## Genomic location

**End position**

175444794

**Start position**

175440027

**Chromosome**

5

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000184845

**HGNC ID**

HGNC:3020

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3020)

**NCBI Gene ID**

1812

**UniProt ID**

P21728

## Cellular location

- Cell membrane
- Multi-pass membrane protein . Endoplasmic reticulum membrane
- Multi-pass membrane protein . Cell projection, cilium membrane
- Multi-pass membrane protein . Cell projection, dendrite . Cell projection, dendritic spine . Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14\. .
- Cytosol
- Plasma membrane

### Publication evidence (2)

- PubMed 23936473  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23936473/)
- PubMed 26182404  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26182404/)

## Tissue expression

**Tissue specificity (tau)**

0.949474

**Expression inequality (Gini)**

0.836031

### Highest expression

Expression in transcripts per million

**Brain - Nucleus accumbens (basal ganglia)**

31.54

**Brain - Caudate (basal ganglia)**

29.46

**Brain - Putamen (basal ganglia)**

22.5

**Brain - Frontal Cortex (BA9)**

5.73

**Brain - Cortex**

4.32

### All tissues (54)

Expression in transcripts per million

- Brain - Nucleus accumbens (basal ganglia)31.54
- Brain - Caudate (basal ganglia)29.46
- Brain - Putamen (basal ganglia)22.5
- Brain - Frontal Cortex (BA9)5.73
- Brain - Cortex4.32
- Brain - Anterior cingulate cortex (BA24)3.5
- Brain - Amygdala2.08
- Prostate1.17
- Lung1.08
- Bladder1.07
- Brain - Hippocampus1.05
- Artery - Aorta0.89
- Kidney - Medulla0.77
- Brain - Hypothalamus0.72
- Cervix - Endocervix0.71
- Cervix - Ectocervix0.62
- Vagina0.62
- Fallopian Tube0.61
- Nerve - Tibial0.6
- Adipose - Visceral (Omentum)0.58
- Brain - Cerebellum0.45
- Uterus0.44
- Small Intestine - Terminal Ileum0.4
- Artery - Tibial0.36
- Adrenal Gland0.35

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (8)

- GO:0007187  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007187)
- GO:0007189  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007189)
- GO:0007191  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007191)
- GO:0042417  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042417)
- GO:0051281  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051281)
- GO:0051584  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051584)
- GO:0060158  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060158)
- GO:0071870  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071870)

### Cellular components (6)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0005929  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005929)
- GO:0045211  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045211)
- GO:0060170  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060170)
- GO:0097648  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097648)
- GO:0097730  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097730)

### Molecular functions (7)

- GO:0001588  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001588)
- GO:0001965  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001965)
- GO:0004952  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004952)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0032795  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032795)
- GO:0035240  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035240)
- GO:1990763  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990763)

## On-target safety

- neurodegeneration  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: neurodegeneration  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- headache  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: headache  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- convulsions  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: convulsions  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased urinary sodium excretion  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased urinary sodium excretion  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased convulsions  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased convulsions  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- drug abuse/dependence  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: drug abuse/dependence  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- dizziness  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: dizziness  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- suicidal intent  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: suicidal intent  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- catalepsy  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: catalepsy  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- parkinsonism  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: parkinsonism  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased blood pressure  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased blood pressure  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased blood pressure  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased blood pressure  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased urine excretion  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased urine excretion  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- heart failure  
### Effects

  - Activation/Increase/Upregulation: chronic  
### Studies

  - preclinical: heart failure  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased arousal  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased arousal  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased/decreased locomotor activity  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased/decreased locomotor activity  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- depression  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: depression  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- anxiety  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: anxiety  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- psychosis  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: psychosis  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased locomotor activity  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased locomotor activity  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- dyskinesia  
### Effects (2)

  - Inhibition/Decrease/Downregulation: acute
  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: dyskinesia  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- nausea  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: nausea  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- fibrotic valvular heart disease  
### Effects

  - Activation/Increase/Upregulation: chronic  
### Studies

  - preclinical: fibrotic valvular heart disease  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

## Off-target safety

- abuse potential  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: abuse potential  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- nausea  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: nausea  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- depression  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: depression  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- receptor binding  
### Studies

  - biochemical: NVS\_GPCR\_hDRD1, is one of one assay component(s) measured or calculated from the NVS\_GPCR\_hDRD1 assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology.  
### Biological samples

  - cell-free  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)
- dizziness  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: dizziness  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- parkinsonian symptoms (tremors)  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: parkinsonian symptoms (tremors)  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- headaches  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: headaches  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- decreased blood pressure  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: decreased blood pressure  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- dyskinesia  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: dyskinesia  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- natriuresis  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: natriuresis  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- vascular relaxation  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: vascular relaxation  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- anxiety  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: anxiety  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- suicidal intent  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: suicidal intent  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- anti-emetic effects  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: anti-emetic effects  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)

## Related records

### Trials (68)

- A 2-Part Trial of CVL-751 in Subjects With Parkinson's Disease
- A Clinical Trial of Pimozide in Patients With Amyotrophic Lateral Sclerosis (ALS)
- A Drug Interaction Study of LY3154207 in Healthy Participants
- A Phase I Trial to Investigate the Safety and Tolerability of PF-06649751
- A Pilot Study to Investigate Fenoldopam Usage in the Prevention of Postoperative Renal Dysfunction in Patients at a High Risk for Renal Impairment During Cariopulmonary Bypass for Cardiac Surgery
- A Registry-Based Clinical Trial of Pimozide in Patients With Neuromuscular Junction Transmission Dysfunction Due to ALS
- A Study of LY3154207 in Healthy Participants
- A Study of LY3154207 in Healthy Participants and Participants With Parkinson's Disease
- A Study of LY3154207 in Participants With Dementia Due to Lewy Body Dementia (LBD) Associated With Idiopathic Parkinson's Disease (PD) or Dementia With Lewy Bodies (DLB)
- A Study of LY3154207 on Sleep in Healthy Male Participants
- [A Study of Mevidalen (LY3154207) in Participants With Alzheimer's Disease](https://trialight.com/data/trial/a-study-of-mevidalen-ly3154207-in-participants-with-6f76a20e-ba34-4d48-bc91-3592fae0e925.md)
- A Study to Assess the Relative Bioavailability of Oral Tavapadon in Healthy Adult Participants
- A Study to Evaluate LY3154207 on the Brain of Healthy Participants
- A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of PF-06649751 Co-administered With Trimethobenzamide Hydrochloride in Healthy Subjects
- A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of PF-06649751 in Subjects With Idiopathic Parkinson's Disease
- A Study To Observe Safety And Blood Concentrations Of PF-06649751 During And Following The Oral Administration Of Multiple Doses Of PF-06649751 In Healthy Adult Western and Japanese Volunteers
- Adjuvant Therapy With Pergolide in Treating Cognitive Deficits in Schizophrenia
- An Investigation of N-acetylcysteine and Fenoldopam as Renal Protection Agents for Cardiac Surgery
- An Open-label Trial to Evaluate Mass Balance of Tavapadon at Steady State in Healthy Subjects
- Compassionate Use Study of Pergolide in Patients With Parkinson's Disease

### Drugs (16)

- Amineptine Dopamine D1 and D2 receptor antagonist
- Amoxapine Dopamine receptor antagonist
- Ecopipam Dopamine D1 receptor antagonist
- Ergoloid Dopamine receptor agonist
- Ergoloid mesylates Dopamine receptor agonist
- Fenoldopam Dopamine D1 receptor agonist
- Fenoldopam mesylate Dopamine D1 receptor agonist
- Methylergonovine Dopamine D1 receptor antagonist
- Methylergonovine maleate Dopamine D1 receptor antagonist
- [Mevidalen](https://trialight.com/data/asset/mevidalen-5d8f93b3-ecf1-4121-9f3e-d2dc63c1793a.md) Dopamine D1 receptor positive allosteric modulator
- Minaprine Dopamine D1 and D2 receptor agonist
- Minaprine hydrochloride Dopamine D1 and D2 receptor agonist
- Pergolide Dopamine receptor agonist
- Pergolide mesylate Dopamine receptor agonist
- Pimozide Dopamine receptor antagonist
- Tavapadon Dopamine D1 receptor partial agonist

---

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