> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/dpyd-350a1314-e4c8-5e4a-969a-7dd0aed96548
> Record changed: 2026-10-13

# DPYD

ENSG00000188641

Target class

Enzyme

Chromosome

1

Approved drugs

0

Clinical candidates (approved and in development)

2

## Clinical evidence

**Approved drugs**

0

**Clinical candidates (approved and in development)**

2

## Druggability

**Chemical probe available**

No

## Names

**Target name**

DPYD

**Gene name**

Dihydropyrimidine dehydrogenase

**Gene symbol**

DPYD

**Protein name**

Dihydropyrimidine dehydrogenase \[NADP(+)\] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase)

### Other names (2)

- DPD
- DHPDHase

## Classification

**Gene biotype**

Protein coding

**Gene family**

Flavoproteins

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

52

**Highest tissue expression**

43.02

**Tissue specificity (Gini)**

0.432

**Tissue specificity (tau)**

0.745

## Pathways and interactions

**KEGG gene identifiers**

- hsa:1806

**Reactome pathways**

- R-HSA-73621

**Protein interaction confidence**

0.837286

**Protein interaction partners**

49

## Genomic location

**End position**

97995000

**Start position**

97077743

**Chromosome**

1

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000188641

**HGNC ID**

HGNC:3012

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3012)

**NCBI Gene ID**

1806

**UniProt ID**

Q12882

## Cellular location

- Cytoplasm.

## Tissue expression

**Tissue specificity (tau)**

0.744893

**Expression inequality (Gini)**

0.432214

### Highest expression

Expression in transcripts per million

**Cells - Cultured fibroblasts**

43.02

**Lung**

29.63

**Adipose - Visceral (Omentum)**

23.99

**Adipose - Subcutaneous**

23.28

**Cervix - Ectocervix**

23.04

### All tissues (54)

Expression in transcripts per million

- Cells - Cultured fibroblasts43.02
- Lung29.63
- Adipose - Visceral (Omentum)23.99
- Adipose - Subcutaneous23.28
- Cervix - Ectocervix23.04
- Artery - Coronary22.22
- Vagina21.57
- Ovary21.33
- Artery - Tibial21.08
- Cervix - Endocervix20.41
- Nerve - Tibial20.16
- Whole Blood20.11
- Uterus19.49
- Spleen19.28
- Breast - Mammary Tissue19.13
- Bladder17.69
- Colon - Sigmoid16.94
- Fallopian Tube16.62
- Thyroid15.17
- Artery - Aorta15.13
- Esophagus - Gastroesophageal Junction14.13
- Esophagus - Mucosa13.82
- Minor Salivary Gland13.14
- Esophagus - Muscularis13.07
- Liver12.42

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (8)

- GO:0006145  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006145)
- GO:0006208  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006208)
- GO:0006210  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006210)
- GO:0006212  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006212)
- GO:0006214  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006214)
- GO:0042178  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042178)
- GO:0046045  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046045)
- GO:0046050  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046050)

### Cellular components (2)

- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)

### Molecular functions (3)

- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0017113  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017113)
- GO:0042803  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803)

## Related records

### Trials (20)

- [A LM-302 Combination With Other Anti-Tumor Therapies Phase ll Study](https://trialight.com/data/trial/a-lm-302-combination-with-other-anti-tumor-therapies-phase-f867e7b8-f10d-4281-8491-ff6441459c77.md)
- A Phase II Study of Gimatecan (ST1481) in Locally Advanced or Metastatic Pancreatic Cancer
- A Study of Intraperitoneal Paclitaxel in Combination With SOX Compared With SOX Alone in Gastric Cancer With Malignant Ascites
- CCRT Followed by Tegafur, Gimeracil and Oteracil Potassium in Cervical Cancer
- Clinical Study of Endostar Injection Concomitant With SOX Protocols to Treat Advanced Gastric Cancer
- DC-CIK In Combination With Chemotherapy ( Gio / Oxaliplatin or Cisplatin ) Versus First-line Chemotherapy for Locally Advanced Unresectable or Metastatic Gastric Adenocarcinoma Randomized Controlled Phase II Clinical Study of Treatment
- Diffuse Gastric and Esophagogastric Junction Cancer S-1 Trial
- Docetaxel+Oxaliplatin+S-1 (DOS) Regimen as Neoadjuvant Chemotherapy in Advanced Gastric Cancer
- Effect and Safety of Huaier Granule Versus SOX Regimen in Gastric Cancer Patients
- Endostar Combined With MPFC Adjuvant Treatment of Esophageal Cancer Clinical Trial
- Eniluracil and Surgery in Treating Patients With Primary or Metastatic Colorectal Cancer
- Eniluracil Hand Foot Syndrome
- Fluorouracil With or Without Eniluracil in Treating Patients With Advanced Colorectal Cancer
- Neoadjuvant and Adjuvant Therapy Studies of Sintilimab Combined With Chemotherapy With or Without Ipilimumab N01 in Resectable Gastric/Gastroesophageal Junction Adenocarcinoma
- Perioperative Chemotherapy for Potentially Resectable Gastric Cancer
- Perioperative Therapy for HER2-negative Hepatoid Adenocarcinoma of Stomach
- Phase II Study of TS-1 Therapy and TS-1+PSK Therapy Against Advanced Gastric Carcinoma
- Rilvegostomig + Chemotherapy as Adjuvant Therapy for Biliary Tract Cancer After Resection (ARTEMIDE-Biliary01)
- Study of Eniluracil + 5-Fluorouracil (5-FU) + Leucovorin Versus Capecitabine in Metastatic Breast Cancer
- Tripletrumab Combined With Oxaliplatin and Teggio (SOX) in First-line Treatment of Gastric and Gastroesophageal Junction Adenocarcinoma

### Drugs (2)

- Eniluracil Dihydropyrimidine dehydrogenase inhibitor
- [Gimeracil](https://trialight.com/data/asset/gimeracil-c6721c9d-7d42-4068-8b71-6afa2501a8e4.md) Dihydropyrimidine dehydrogenase inhibitor

---

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