> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/dnmt1-993c1dd6-907e-5847-b9a6-2bc7fd678568
> Record changed: 2026-10-13

# DNMT1

ENSG00000130816

Target class

Epigenetic regulator

Chromosome

19

Approved drugs

2

Clinical candidates (approved and in development)

2

## Clinical evidence

**Approved drugs**

2

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

2

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

DNMT1

**Gene name**

DNA methyltransferase 1

**Gene symbol**

DNMT1

**Previous gene symbols**

- DNMT

**Protein name**

DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)

### Other names (2)

- MCMT
- CXXC9

## Classification

**Gene biotype**

Protein coding

**Gene family**

Zinc fingers CXXC-type|7BS C5-cytosine DNA/RNA methyltransferases|DNA/RNA methyltransferases

**Target class**

Epigenetic regulator

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

83.96

**Tissue specificity (Gini)**

0.368

**Tissue specificity (tau)**

0.772

## Pathways and interactions

**KEGG gene identifiers**

- hsa:1786

**Protein interaction confidence**

0.870206

**Protein interaction partners**

126

### Reactome pathways (7)

- R-HSA-212300
- R-HSA-427413
- R-HSA-4655427
- R-HSA-5334118
- R-HSA-9701898
- R-HSA-9710421
- R-HSA-9725371

## Genomic location

**End position**

10231286

**Start position**

10133342

**Chromosome**

19

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000130816

**HGNC ID**

HGNC:2976

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2976)

**NCBI Gene ID**

1786

**UniProt ID**

P26358

## Cellular location

- Nucleus . Chromosome . Note=Associates with replication foci during S-phase: recruited to hemimethylated DNA sites via its RFTS domain, which specifically recognizes and binds histone H3 ubiquitinated at 'Lys-14', 'Lys-18' and 'Lys-23' (H3K14ub, H3K18ub and H3K23ub, respectively) (PubMed:29053958). Localized to the perinucleolar region (PubMed:24492612). .
- Nucleoplasm

### Publication evidence (3)

- PubMed 12145218  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12145218/)
- PubMed 24492612  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24492612/)
- PubMed 29053958  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/29053958/)

## Tissue expression

**Tissue specificity (tau)**

0.771992

**Expression inequality (Gini)**

0.367915

### Highest expression

Expression in transcripts per million

**Cells - EBV-transformed lymphocytes**

83.96

**Testis**

56.59

**Brain - Cerebellar Hemisphere**

54.82

**Brain - Cerebellum**

53.62

**Cells - Cultured fibroblasts**

46.47

### All tissues (54)

Expression in transcripts per million

- Cells - EBV-transformed lymphocytes83.96
- Testis56.59
- Brain - Cerebellar Hemisphere54.82
- Brain - Cerebellum53.62
- Cells - Cultured fibroblasts46.47
- Cervix - Endocervix32.67
- Nerve - Tibial31.73
- Lung30.02
- Cervix - Ectocervix29.98
- Uterus29.18
- Spleen28.69
- Fallopian Tube28.64
- Small Intestine - Terminal Ileum24.83
- Vagina24.19
- Bladder23.45
- Breast - Mammary Tissue22.81
- Thyroid22.35
- Adipose - Subcutaneous22.29
- Ovary21.95
- Pituitary20.68
- Esophagus - Mucosa20.48
- Skin - Sun Exposed (Lower leg)20.3
- Skin - Not Sun Exposed (Suprapubic)20.1
- Artery - Coronary19.5
- Prostate18.77

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (9)

- GO:0000122  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122)
- GO:0010628  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628)
- GO:0010629  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010629)
- GO:0044027  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044027)
- GO:0141119  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0141119)
- GO:1900240  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900240)
- GO:1904707  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904707)
- GO:1905064  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905064)
- GO:1905460  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905460)

### Cellular components (5)

- GO:0000792  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000792)
- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005654  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654)
- GO:0005694  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005694)
- GO:0005739  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739)

### Molecular functions (8)

- GO:0003677  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003677)
- GO:0003886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003886)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0009008  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009008)
- GO:0140254  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140254)
- GO:0140257  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140257)
- GO:0140258  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140258)
- GO:1990841  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990841)

## Related records

### Trials (1,090)

- "InDACtion" vs "3+7" Induction in AML
- 10-day Decitabine, Fludarabine and 2 Gray TBI as Conditioning Strategy for Poor and Very Poor Risk AML in CR1
- 5 Day Versus 7 Day Azacitidine in Lower Risk Myelodysplastic Syndrome
- 5-aza-2-deoxycytidine With Pegylated Interferon-alfa 2B: A Phase I Study With Molecular Correlates
- 5-Azacitidine and Decitabine Epigenetic Therapy for Myeloid Malignancies
- A Biomarker-Directed Phase 2 Trial of Tamibarotene (SY-1425) in Participants With Acute Myeloid Leukemia or Myelodysplastic Syndrome
- A Clinical Trail of Demethylation Drug Combined With Chemotherapy in Intermediate-risk AML
- A Clinical Trial Evaluating the Efficacy of Ultra Low Dose of Decitabine in Myelodysplastic Syndromes (MDS)
- A Clinical Trial of BP1002 in Patients With Refractory/Relapsed Acute Myeloid Leukemia (AML)
- A Clinical Trial of Cidabenamine Plus Azacitidine to Prevent Post-Transplant Progression in High-Risk Peripheral T-Cell Lymphoma
- A Clinical Trial of Decitabine in Patients With Myelodysplastic Syndrome
- A Clinical Trial of Decitabine in Relapse and Refractory Diffuse Large B Cell Lymphoma
- A Clinical Trial of Decitabine in Relapsed or Refractory T-lymphoblastic Lymphoma
- A Clinical Trial of Omacetaxine, Azacitidine, and Growth-Colony Stimulating Factor (G-CSF) for Myelodysplastic Syndromes (MDS)
- A Clinical Trial of TQB3455 Tablets in Patients With Hematological Malignancies
- A Clinical Trial of TQB3909 Tablets in Combination With Azacitidine for the Treatment of Myeloid Malignancies
- A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma
- A Combination Study of PF-04449913 (Glasdegib) and Azacitidine In Untreated MDS, AML and CMML Patients
- A Dose-Finding and Efficacy Study of Venetoclax, CC-486, and Obinutuzumab in Follicular Lymphoma
- A Multi-center Study of Low-dose Decitabine for the Treatment of Immune Thrombocytopenia

### Drugs (2)

- [Azacitidine](https://trialight.com/data/asset/azacitidine-4f3798ea-680c-4288-a367-118b7bfe411f.md) DNA (cytosine-5)-methyltransferase 1 inhibitor
- Decitabine DNA (cytosine-5)-methyltransferase 1 inhibitor

---

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