> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/dll3-e4896a67-4fec-59a7-b840-73ec971001e0
> Record changed: 2026-10-13

# DLL3

ENSG00000090932

Target class

Unclassified protein

Chromosome

19

Approved drugs

1

Clinical candidates (approved and in development)

2

## Clinical evidence

**Approved drugs**

1

**Clinical candidates (approved and in development)**

2

## Druggability

**Chemical probe available**

No

## Names

**Other names**

- SCDO1

**Target name**

DLL3

**Gene name**

Delta like canonical Notch ligand 3

**Gene symbol**

DLL3

**Protein name**

Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3)

## Classification

**Gene biotype**

Protein coding

**Gene family**

Canonical Notch ligands

**Target class**

Unclassified protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

15

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

11.43

**Tissue specificity (Gini)**

0.756

**Tissue specificity (tau)**

0.87

## Pathways and interactions

**KEGG gene identifiers**

- hsa:10683

**Protein interaction confidence**

0.887917

**Protein interaction partners**

12

### Reactome pathways (2)

- R-HSA-9793380
- R-HSA-9824272

## Genomic location

**End position**

39508481

**Start position**

39498895

**Chromosome**

19

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000090932

**HGNC ID**

HGNC:2909

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2909)

**NCBI Gene ID**

10683

**UniProt ID**

Q9NYJ7

## Cellular location

- Membrane
- Single-pass type I membrane protein .
- Golgi apparatus
- Nucleoplasm
- Plasma membrane

## Tissue expression

**Tissue specificity (tau)**

0.869856

**Expression inequality (Gini)**

0.755981

### Highest expression

Expression in transcripts per million

**Brain - Nucleus accumbens (basal ganglia)**

11.43

**Brain - Hypothalamus**

8.56

**Brain - Amygdala**

8.27

**Brain - Anterior cingulate cortex (BA24)**

6.84

**Brain - Caudate (basal ganglia)**

6.47

### All tissues (54)

Expression in transcripts per million

- Brain - Nucleus accumbens (basal ganglia)11.43
- Brain - Hypothalamus8.56
- Brain - Amygdala8.27
- Brain - Anterior cingulate cortex (BA24)6.84
- Brain - Caudate (basal ganglia)6.47
- Brain - Hippocampus6.24
- Brain - Frontal Cortex (BA9)6.2
- Brain - Cortex5.53
- Brain - Putamen (basal ganglia)5.45
- Pituitary4.95
- Brain - Substantia nigra4.48
- Testis3.28
- Brain - Spinal cord (cervical c-1)3.14
- Brain - Cerebellar Hemisphere2.89
- Brain - Cerebellum2.47
- Cells - Cultured fibroblasts0.91
- Cells - EBV-transformed lymphocytes0.61
- Ovary0.3
- Thyroid0.26
- Spleen0.18
- Nerve - Tibial0.17
- Small Intestine - Terminal Ileum0.14
- Vagina0.1
- Cervix - Endocervix0.09
- Colon - Sigmoid0.09

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes

- GO:0001501  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001501)

## Related records

### Trials (51)

- A Long-Term Study of Rovalpituzumab Tesirine
- A Multicenter Phase II Trial to Evaluate Rechallenge With Platinum-based Chemotherapy (Carboplatin, Etoposide) for Progression During Tarlatamab Therapy in Relapsed Extensive Disease Small-cell Lung Cancer (SCLC)
- A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC)
- A Phase 2, Open-label, Randomized, Multicenter Study of Tarlatamab Dosing Regimens in Subjects With SCLC
- A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)
- A Study of AMG 757 in Participants With Neuroendocrine Prostate Cancer
- A Study of Budigalimab (ABBV-181) in Participants With Advanced Solid Tumors
- [A Study of GSK5764227 in Participants With Advanced Solid Tumors (EMBOLD)](https://trialight.com/data/trial/a-study-of-gsk5764227-in-participants-with-advanced-solid-d2e9bd29-43c1-4a7d-9867-c96e4b997562.md)
- A Study of Rovalpituzumab Tesirine (SC16LD6.5) in the Frontline Treatment of Patients With Extensive Stage Small Cell Lung Cancer
- A Study of Rovalpituzumab Tesirine Administered in Combination With Nivolumab and With or Without Ipilimumab for Adults With Extensive-Stage Small Cell Lung Cancer
- A Study of Rovalpituzumab Tesirine as Maintenance Therapy Following First- Line Platinum-Based Chemotherapy in Participants With Extensive Stage Small Cell Lung Cancer (MERU)
- A Study of Rovalpituzumab Tesirine to Study Cardiac Ventricular Repolarization in Subjects With Small Cell Lung Cancer
- A Study of Tarlatamab for People With Prostate Cancer
- [A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)](https://trialight.com/data/trial/a-study-of-tarlatamab-in-combination-with-ab248-in-ec21a245-9aca-4fbc-971c-eb5a21581c23.md)
- A Study on the Safety and Tolerability of Rovalpituzumab Tesirine in Japanese Patients With Advanced, Recurrent Small Cell Lung Cancer
- A Trial of Tarlatamab in Patients With Pretreated Extensive-stage Small Cell Lung Cancer (ES-SCLC) and ECOG PS 2
- AMG 757 and AMG 404 in Subjects With Small Cell Lung Cancer (SCLC)
- Bispecific T-Cell Engager Tarlatamab and TROP2 Targeted Antibody Drug Conjugate Sacituzumab Govitecan in Previously Treated Extensive-Stage Small Cell Lung Cancer and Extrapulmonary Neuroendocrine Cancer
- Clinical Trial for Safety and Effectiveness Evaluation of Tarlatamab (AMG757) With Etoposide, Carboplatin and Atezolizumab in Transformed Small Cell Lung Cancer Patients From Adenocarcinoma After EGFR TKI Treatment
- Combination of Tarlatamab and Temozolomide in Patients With Central Nervous System Tumors

### Drugs (2)

- Rovalpituzumab tesirine Delta-like protein 3 binding agent
- [Tarlatamab](https://trialight.com/data/asset/tarlatamab-23a11ca8-5d77-4625-92aa-242339e9a92b.md) Delta-like protein 3 binding agent

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