> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/dhodh-f1839c21-23d1-56b9-b154-89a8d65a86ba > Record changed: 2026-10-13 # DHODH ENSG00000102967 Target class Enzyme Chromosome 16 Approved drugs 2 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 2 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** Yes ## Names **Target name** DHODH **Gene name** Dihydroorotate dehydrogenase (quinone) **Gene symbol** DHODH **Protein name** Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase) ## Classification **Gene biotype** Protein coding **Gene family** Flavoproteins **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Enhanced **Highest tissue expression** 43.83 **Tissue specificity (Gini)** 0.35 **Tissue specificity (tau)** 0.907 ## Pathways and interactions **KEGG gene identifiers** - hsa:1723 **Reactome pathways** - R-HSA-500753 **Protein interaction confidence** 0.825744 **Protein interaction partners** 39 ## Genomic location **End position** 72027664 **Start position** 72008588 **Chromosome** 16 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000102967 **HGNC ID** HGNC:2867 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2867) **NCBI Gene ID** 1723 **UniProt ID** Q02127 ## Cellular location - Mitochondrion inner membrane - Single-pass membrane protein . - Cytosol - Mitochondria - Nucleoplasm ### Publication evidence - PubMed 10727948 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10727948/) ## Tissue expression **Tissue specificity (tau)** 0.907369 **Expression inequality (Gini)** 0.349853 ### Highest expression Expression in transcripts per million **Liver** 43.83 **Cells - EBV-transformed lymphocytes** 8.62 **Nerve - Tibial** 7.52 **Heart - Atrial Appendage** 7.28 **Fallopian Tube** 7.12 ### All tissues (54) Expression in transcripts per million - Liver43.83 - Cells - EBV-transformed lymphocytes8.62 - Nerve - Tibial7.52 - Heart - Atrial Appendage7.28 - Fallopian Tube7.12 - Ovary6.93 - Cervix - Ectocervix6.5 - Cervix - Endocervix6.47 - Adipose - Visceral (Omentum)6.35 - Uterus6.23 - Thyroid6.17 - Testis5.9 - Cells - Cultured fibroblasts5.13 - Breast - Mammary Tissue5.11 - Spleen5.1 - Bladder4.96 - Prostate4.93 - Lung4.78 - Adipose - Subcutaneous4.61 - Vagina4.55 - Artery - Coronary4.28 - Colon - Sigmoid4.01 - Pituitary4.01 - Artery - Tibial4 - Skin - Sun Exposed (Lower leg)3.99 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components (2) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0005743 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005743) ### Molecular functions (2) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0106430 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106430) ## Related records ### Trials (175) - A Clinical Study of Xin'an Medicine in the Treatment of Bi Syndrome - A Dose Optimisation Study of ASLAN003 in Acute Myeloid Leukemia - A Phase 1, 2-Part Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Multiple Doses of ASLAN003 in Healthy Elderly Subjects - A Phase I Study of SU101 in Pediatric Patients With Refractory Malignancy - A Prospective Randomized Non-inferiority Trial Comparing Anti-CD20 Maintenance Versus De-Escalation Strategy In Relapsing-Remitting Multiple Sclerosis - A Study Assessing the Safety and Efficacy of Sarilumab Added to Non-MTX DMARDs or as Monotherapy in Japanese Patients With Active Rheumatoid Arthritis (SARIL-RA-HARUKA) - A Study Comparing the Effectiveness and Safety of Teriflunomide and Interferon Beta-1a in Patients With Relapsing Multiple Sclerosis - A Study of Brequinar in Subjects With Relapsed/Refractory Acute Myeloid Leukemia - A Study of Ocrelizumab Compared to Placebo in Patients With Active Rheumatoid Arthritis Who Don't Have a Response to Anti-TNF-α Therapy (SCRIPT) - A Study of Subcutaneous Tocilizumab as Monotherapy and/or in Combination With Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Rheumatoid Arthritis - A Study of the Effectiveness of Additional Risk Minimization Measures Related to ARAVA® (Leflunomide) in Saudi Arabia - A Study to Compare the Efficacy and Safety of Tacrolimus Capsules With Leflunomide Tablets in Lupus Nephritis Patients - A Study to Evaluate Efficacy and Safety of PTC299 (Emvododstat) in Hospitalized Participants With Coronavirus (COVID-19) - A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS) - A Study to Evaluate the Efficacy and Safety of MLTA3698A in Combination With a Disease-Modifying Anti-Rheumatic Drug (DMARD) Compared With Adalimumab in Combination With a DMARD in Patients With Active Rheumatoid Arthritis - A Study to Evaluate the Efficacy, Safety and Tolerability of IMU-838 as Addition to Investigator's Choice of Standard of Care Therapy, in Patients With Coronavirus Disease 19 (COVID-19) - A Study to Evaluate the Pharmacokinetic Profiles of Single 14 mg Teriflunomide Tablet in Healthy Chinese Volunteers - A Study to Evaluate the Safety of Long Term Treatment With Teriflunomide 14 mg Once Daily in Patients With a First Clinical Episode Suggestive of Multiple Sclerosis in a Long-term Extension Period - [A Study to Investigate Long-term Safety and Tolerability of Tolebrutinib in Participants With Multiple Sclerosis.](https://trialight.com/data/trial/a-study-to-investigate-long-term-safety-and-tolerability-of-cdd4fe6f-9a19-4ce7-924a-3df50888513c.md) - Acupuncture Study on Rheumatoid Arthritis, Monitoring Microbiome and Blood ### Drugs (6) - Aslan-003 Dihydroorotate dehydrogenase inhibitor - Brequinar Dihydroorotate dehydrogenase inhibitor - Emvododstat Dihydroorotate dehydrogenase inhibitor - Leflunomide Dihydroorotate dehydrogenase inhibitor - [Teriflunomide](https://trialight.com/data/asset/teriflunomide-09959492-b0cc-4b02-af87-76d17c0bd15b.md) Dihydroorotate dehydrogenase inhibitor - [Vidofludimus](https://trialight.com/data/asset/vidofludimus-8f773f25-2942-44a3-b9f6-884b9088a0f0.md) Dihydroorotate dehydrogenase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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