> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ddr2-695ca58b-4172-5979-b027-14030b58a745 > Record changed: 2026-10-13 # DDR2 ENSG00000162733 Target class Kinase Chromosome 1 Approved drugs 1 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** Yes ## Names **Other names** - TKT **Target name** DDR2 **Gene name** Discoidin domain receptor tyrosine kinase 2 **Gene symbol** DDR2 **Protein name** Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b) ### Previous gene symbols (2) - TYRO10 - NTRKR3 ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Approved **Highest tissue expression** 110.24 **Tissue specificity (Gini)** 0.541 **Tissue specificity (tau)** 0.776 ## Pathways and interactions **KEGG gene identifiers** - hsa:4921 **Reactome pathways** - R-HSA-3000171 **Protein interaction confidence** 0.7755 **Protein interaction partners** 6 ## Genomic location **End position** 162787405 **Start position** 162630863 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000162733 **HGNC ID** HGNC:2731 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2731) **NCBI Gene ID** 4921 **UniProt ID** Q16832 ## Cellular location - Cell membrane - Single-pass type I membrane protein . - Plasma membrane ### Publication evidence (3) - PubMed 18201965 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18201965/) - PubMed 20223752 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20223752/) - PubMed 9659899 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9659899/) ## Tissue expression **Tissue specificity (tau)** 0.776127 **Expression inequality (Gini)** 0.540852 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 110.24 **Colon - Sigmoid** 87.17 **Adrenal Gland** 82.12 **Esophagus - Gastroesophageal Junction** 67.91 **Artery - Tibial** 65.26 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts110.24 - Colon - Sigmoid87.17 - Adrenal Gland82.12 - Esophagus - Gastroesophageal Junction67.91 - Artery - Tibial65.26 - Esophagus - Muscularis63.68 - Adipose - Subcutaneous59.85 - Artery - Coronary59.41 - Cervix - Ectocervix59.18 - Artery - Aorta58.15 - Nerve - Tibial49.56 - Adipose - Visceral (Omentum)49.53 - Uterus46.67 - Ovary45.69 - Fallopian Tube45.3 - Cervix - Endocervix41.58 - Bladder41.49 - Breast - Mammary Tissue37.01 - Colon - Transverse36.65 - Vagina36.42 - Lung25.35 - Thyroid24.43 - Prostate24.15 - Heart - Atrial Appendage19.19 - Small Intestine - Terminal Ileum19.01 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (12) - GO:0007155 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007155) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0010715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010715) - GO:0010763 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010763) - GO:0018108 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108) - GO:0030500 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030500) - GO:0034103 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034103) - GO:0035988 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035988) - GO:0038063 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038063) - GO:0045669 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045669) - GO:0045860 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045860) - GO:0046777 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046777) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) ### Molecular functions (4) - GO:0004714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004714) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005518 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005518) - GO:0038062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038062) ## Related records ### Trials (389) - "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer" - (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST - \[18F\]FLT-PET as a Predictive Imaging Biomaker of Treatment Responses to Regorafenib - \[18F\]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial - \[18F\]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma - \[68 Ga\]-DOTANOC PET/CT in GEP-NETs - \[68Ga\]Ga-FAPI-46 in Staging of Head and Neck Carcinomas - \[68Ga\]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation - 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET) - 18F-DCFBC PET/CT in Prostate Cancer - 18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer - 5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer - 68Ga-NODAGA-RGD PET/ CT for Tumoral Neoangiogenesis - 68Ga-NY104 PET/CT Guided Radiation Therapy in CcRCC. - 68Ga-NYM096/177Lu-NYM096 in Metastatic ccRCC - 68Ga-PSMA PET/CT in Prostate Cancer - 68Ga-PSMA PET/CT in Prostate Cancer - 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Intermediate Risk Prostate Cancer Imaging - 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Prostate Cancer Imaging According to Various Metastatic Risks - 89Zr-TLX250 for PET/CT Imaging of ccRCC - ZIRCON-CP Study ### Drugs (1) - [Regorafenib](https://trialight.com/data/asset/regorafenib-333c1c36-b89a-41d5-b39e-bcec7346fe94.md) Discoidin domain-containing receptor 2 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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