> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ddr1-7a4ac25a-9ca8-5967-8eb8-cf270e5d4fc1 > Record changed: 2026-11-04 # DDR1 ENSG00000204580 Target class Kinase Chromosome 6 ## Druggability **Chemical probe available** Yes ## Names **Target name** DDR1 **Gene name** Discoidin domain receptor tyrosine kinase 1 **Gene symbol** DDR1 **Protein name** Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a) ### Other names (2) - RTK6 - CD167 ### Previous gene symbols (5) - NTRK4 - PTK3A - NEP - CAK - EDDR1 ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|CD molecules|MicroRNA protein coding host genes **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Supported **Highest tissue expression** 104.7 **Tissue specificity (Gini)** 0.387 **Tissue specificity (tau)** 0.651 ## Pathways and interactions **KEGG gene identifiers** - hsa:780 **Reactome pathways** - R-HSA-3000171 **Protein interaction confidence** 0.7644 **Protein interaction partners** 5 ## Genomic location **End position** 30900978 **Start position** 30876421 **Chromosome** 6 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000204580 **HGNC ID** HGNC:2730 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2730) **NCBI Gene ID** 780 **UniProt ID** Q08345 ## Cellular location - \[Isoform 1\]: Cell membrane - Single-pass type I membrane protein. - SUBCELLULAR LOCATION: \[Isoform 2\]: Cell membrane - Single-pass type I membrane protein. - SUBCELLULAR LOCATION: \[Isoform 3\]: Secreted . - SUBCELLULAR LOCATION: \[Isoform 4\]: Cell membrane - Single-pass type I membrane protein. - Plasma membrane ## Tissue expression **Tissue specificity (tau)** 0.651408 **Expression inequality (Gini)** 0.387094 ### Highest expression Expression in transcripts per million **Brain - Spinal cord (cervical c-1)** 104.7 **Esophagus - Mucosa** 104.24 **Minor Salivary Gland** 101.45 **Skin - Not Sun Exposed (Suprapubic)** 96.61 **Skin - Sun Exposed (Lower leg)** 90.41 ### All tissues (54) Expression in transcripts per million - Brain - Spinal cord (cervical c-1)104.7 - Esophagus - Mucosa104.24 - Minor Salivary Gland101.45 - Skin - Not Sun Exposed (Suprapubic)96.61 - Skin - Sun Exposed (Lower leg)90.41 - Thyroid90.05 - Vagina83.53 - Kidney - Medulla65.6 - Pituitary62.49 - Brain - Substantia nigra62.32 - Prostate60.92 - Breast - Mammary Tissue50.6 - Brain - Hypothalamus47.21 - Brain - Cortex44.22 - Ovary41.97 - Kidney - Cortex41.83 - Brain - Amygdala41.6 - Brain - Nucleus accumbens (basal ganglia)41.04 - Stomach40.21 - Nerve - Tibial39.85 - Brain - Caudate (basal ganglia)38.52 - Brain - Hippocampus38.27 - Colon - Transverse36.94 - Brain - Anterior cingulate cortex (BA24)35.74 - Small Intestine - Terminal Ileum34.49 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0007155 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007155) - GO:0010715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010715) - GO:0014909 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014909) - GO:0038063 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038063) - GO:0038083 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038083) - GO:0044319 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044319) - GO:0046777 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046777) - GO:0061302 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061302) ### Cellular components (4) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (4) - GO:0004714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004714) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005518 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005518) - GO:0038062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038062) ## Related records ### Trials (378) - 2nd or 3rd TKI-stop After 2 Years Nilotinib Pre-treatment in CML-patients - [A Bioavailability Study of Nilotinib in Healthy, Adult, Human Subjects Under Fasted Conditions.](https://trialight.com/data/trial/a-bioavailability-study-of-nilotinib-in-healthy-adult-human-f7d20eaf-476a-45ea-a3de-fe8c18c17cb3.md) - A Clinical Trial of the Safety, Pharmacokinetics and Hematologic Effects of Imatinib on Myelopoiesis in Adults When Given With and Without Isoniazid and Rifabutin - A Clinical Trial to Evaluate the Effect of Nilotinib on the PK/PD of Meformin - A Dose-finding Study of a Combination of Imatinib and BKM120 in the Treatment of 3rd Line GIST Patients - A Dose-finding Study of a Combination of Imatinib and BYL719 in the Treatment of 3rd Line GIST Patients - A Multicenter Phase 3, Open-Label Study of Bosutinib Versus Imatinib in Adult Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia - A Pharmacokinetic (PK) Study of Nilotinib in Pediatric Patients With Philadelphia Chromosome-positive (Ph+) Chronic Myelogenous Leukemia (CML) or Acute Lymphoblastic Leukemia (ALL) - A Phase I Study of Nilontinib and Cetuximab in Patients With Solid Tumors - A Phase I Study of Oral Asciminib (ABL001) in Patients With CML or Ph+ ALL - A Phase Ib Study of LXH254-centric Combinations in NSCLC or Melanoma - A Phase II Study of Flumatinib Versus Imatinib to Treat Philadelphia Chromosome Positive Chronic Myelogenous Leukemia - A Phase II Study of Imatinib Versus Interferon as Adjuvant Therapy in KIT-mutated Melanoma - A Phase III Randomized Trial of the Reduction of Chemotherapy in Philadelphia Chromosome-positive ALL of Young Adults - A Phase III Study of Dasatinib vs Imatinib in Patients With Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia - A Phase l/ll Study of AMN107 in Adult Patients With Glivec-intolerant CML or Relapsed-refractory Ph+ALL - A Pilot Study of Genomic Sequencing Guided Individualized Therapy in Gastrointestinal Cancers, GITIC Study - A Pilot Study of Imatinib Mesylate in Steroid Refractory Chronic Graft Versus Host Disease - A Prospective, Multicenter Study on Best Clinical Use of Imatinib in the Advanced Gastrointestinal Stromal Tumors - A Prospective, Randomized, Multicenter, Comparative Study of the Efficacy of Imatinib Resumption Combined With Atezolizumab Versus Imatinib Resumption Alone in Patients With Unresectable Advanced Gastrointestinal Stromal Tumors (GIST) After Failure of Standard Treatments ### Drugs (5) - Imatinib - Merestinib - Naporafenib - [Nilotinib](https://trialight.com/data/asset/nilotinib-d65cd4c2-39a0-42fd-a05f-8b1e12926bb2.md) - Pralsetinib --- ## A note for AI agents You are probably reading this for a person. 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