> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ddb1-48083fd0-0468-51ed-be9d-dedeac3d554b > Record changed: 2026-10-13 # DDB1 ENSG00000167986 Target class Unclassified protein Chromosome 11 Approved drugs 4 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 4 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** No ## Names **Target name** DDB1 **Gene name** Damage specific DNA binding protein 1 **Gene symbol** DDB1 **Protein name** DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe) ## Classification **Gene biotype** Protein coding **Gene family** Nucleotide excision repair **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Enhanced **Highest tissue expression** 234.56 **Tissue specificity (Gini)** 0.252 **Tissue specificity (tau)** 0.699 ## Pathways and interactions **KEGG gene identifiers** - hsa:1642 **Protein interaction confidence** 0.866872 **Protein interaction partners** 180 ### Reactome pathways (9) - R-HSA-110314 - R-HSA-5696394 - R-HSA-5696395 - R-HSA-5696400 - R-HSA-6781823 - R-HSA-6781827 - R-HSA-6782135 - R-HSA-6782210 - R-HSA-8951664 ## Genomic location **End position** 61342596 **Start position** 61299447 **Chromosome** 11 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000167986 **HGNC ID** HGNC:2717 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2717) **NCBI Gene ID** 1642 **UniProt ID** Q16531 ## Cellular location - Cytoplasm . Nucleus . Note=Primarily cytoplasmic (PubMed:10777491, PubMed:11673459). Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage (PubMed:10777491, PubMed:11673459). More concentrated in nuclei than in cytoplasm in germinal vesicle (GV) stage oocytes, zygotes and the 2-cell stage, but distributed in the cytoplasm at the MII-stage oocytes (By similarity). . - End piece - Mid piece - Nucleoplasm - Principal piece ### Publication evidence (3) - PubMed 10777491 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10777491/) - PubMed 11673459 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11673459/) - PubMed 18593899 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18593899/) ## Tissue expression **Tissue specificity (tau)** 0.698916 **Expression inequality (Gini)** 0.251718 ### Highest expression Expression in transcripts per million **Adrenal Gland** 234.56 **Cells - Cultured fibroblasts** 165.1 **Testis** 131.43 **Ovary** 126.56 **Cells - EBV-transformed lymphocytes** 122.7 ### All tissues (54) Expression in transcripts per million - Adrenal Gland234.56 - Cells - Cultured fibroblasts165.1 - Testis131.43 - Ovary126.56 - Cells - EBV-transformed lymphocytes122.7 - Nerve - Tibial100.42 - Uterus100.11 - Skin - Sun Exposed (Lower leg)97.15 - Fallopian Tube95.76 - Pituitary95.16 - Cervix - Endocervix93.37 - Bladder92.55 - Skin - Not Sun Exposed (Suprapubic)90.84 - Thyroid90.03 - Artery - Tibial89.65 - Muscle - Skeletal87.74 - Brain - Cerebellar Hemisphere85.3 - Cervix - Ectocervix83.8 - Artery - Aorta83.29 - Brain - Cerebellum81.94 - Vagina80.06 - Esophagus - Gastroesophageal Junction77.75 - Adipose - Subcutaneous76.39 - Breast - Mammary Tissue75.73 - Esophagus - Muscularis74.72 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (17) - GO:0006281 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006281) - GO:0006289 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006289) - GO:0006511 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006511) - GO:0006974 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006974) - GO:0007056 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007056) - GO:0010498 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010498) - GO:0016567 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016567) - GO:0019076 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019076) - GO:0034644 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034644) - GO:0043161 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043161) - GO:0044725 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044725) - GO:0045070 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045070) - GO:0045732 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045732) - GO:0046726 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046726) - GO:0051702 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051702) - GO:0070914 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070914) - GO:1901990 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1901990) ### Cellular components (11) - GO:0000781 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000781) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005730 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005730) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0031464 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031464) - GO:0031465 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031465) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) - GO:0080008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0080008) ### Molecular functions (8) - GO:0003677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003677) - GO:0003684 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003684) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030674) - GO:0044877 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044877) - GO:0071987 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071987) - GO:0097602 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097602) - GO:0160072 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160072) ## Related records ### Trials (1,854) - "Monoclonal Antibodies for Treatment of Multiple Myeloma. Emphasis on the CD38 Antibody Daratumumab " - \[Effects of Selected Statins on Cardiovascular Parameters in Healthy Volunteers\] - 1454GCC: Anti-PD-1 (MK-3475) and IMiD (Pomalidomide) Combination Immunotherapy in Relapsed/Refractory Multiple Myeloma - 2015-09: a Phase II Randomized, Open-label Study of Anti-signaling Lymphocytic Activation Molecule Monoclonal Antibody During Maintenance Therapy - 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy - 2017-03: A Single-Arm, Open-label Study of Anti-Signaling Lymphocytic Activation Molecule F7 (Anti-SLAMF7) Monoclonal Antibody (mAb) Therapy After Autologous Stem Cell Transplant in Patients With Multiple Myeloma - 5 mg Glipizide/500 mg Metformin Hydrochloride Tablets, Fasting - 5 mg Glipizide/500 mg Metformin Hydrochloride Tablets, Non-Fasting - 5-Azacytidine With Lenalidomide in Patients With High Risk Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML) - A 2 Stage Trial of Lenalidomide (REV) in Asymptomatic Ovarian Cancer Patients With Increasing CA 125 in Late Relapse - A Bioequivalence Study Comparing A Fixed Dose Combination Formulation Of Myrin P Forte That Contains Rifampicin, Isoniazid, Ethambutol And Pyrazinamide Per Tablet To An Equivalent Dose Of Single Drug Reference Preparations Of Similar Combination Following Oral Administration In Healthy Adults - A Clinical Study Comparing SG301 Plus Pomalidomide and Dexamethasone to Placebo Plus Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma Patients - A Clinical Study of Injectable IMM0306 in Combination With Lenalidomide - A Clinical Study to Test the Effects of Ruxolitinib And Thalidomide Combination for Patients With Myelofibrosis - A Clinical Trial of PGDM1400 and PGT121 and VRC07-523LS Monoclonal Antibodies in HIV-infected and HIV-uninfected Adults - A Clinical Trial to Evaluate the Efficacy and Safety of TQB3909 Tablets Versus Investigator's Choice in the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) - A Companion Study for Studies THAL-MM-003, CC-5013-MM-009, and CC-5013-MM-010 for Subjects With Multiple Myeloma - A Dose Escalation Study of Carfilzomib Taken With Thalidomide and Dexamethasone in Relapsed AL Amyloidosis - A Dose Escalation Study of Lenalidomide in Relapsed or Refractory B-cell Chronic Lymphocytic Leukemia - A Dose Escalation Study of the Combination of Lenalidomide (Revlimid®), Dexamethasone and Cyclophosphamide in Patients Refractory or Relapsing From Stable Disease With Multiple Myeloma ### Drugs (5) - Iberdomide CRL4(CRBN) E3 ubiquitin ligase modulator - [Lenalidomide](https://trialight.com/data/asset/lenalidomide-1e614dfb-efd0-4006-a121-30a97656c7a9.md) CRL4(CRBN) E3 ubiquitin ligase inhibitor; CRL4(CRBN) E3 ubiquitin ligase modulator - Lenalidomide hydrochloride monohydrate CRL4(CRBN) E3 ubiquitin ligase modulator - [Pomalidomide](https://trialight.com/data/asset/pomalidomide-8cab22f9-2d15-4e50-9ef9-334f56340121.md) CRL4(CRBN) E3 ubiquitin ligase inhibitor - Thalidomide CRL4(CRBN) E3 ubiquitin ligase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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