DDB1

ENSG00000167986
Target class
Unclassified protein
Chromosome
11
Approved drugs
4
Clinical candidates (approved and in development)
5

Approved drugs
4
Clinical candidates (approved and in development)
5

Chemical probe available
No

Target name
DDB1
Gene name
Damage specific DNA binding protein 1
Gene symbol
DDB1
Protein name
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)

Gene biotype
Protein coding
Gene family
Nucleotide excision repair
Target class
Unclassified protein
Target type
Human gene

Tissues expressed in
54
Protein localisation evidence grade
Enhanced
Highest tissue expression
234.56
Tissue specificity (Gini)
0.252
Tissue specificity (tau)
0.699

KEGG gene identifiers
  • hsa:1642
Protein interaction confidence
0.866872
Protein interaction partners
180

  • R-HSA-110314
  • R-HSA-5696394
  • R-HSA-5696395
  • R-HSA-5696400
  • R-HSA-6781823
  • R-HSA-6781827
  • R-HSA-6782135
  • R-HSA-6782210
  • R-HSA-8951664

End position
61342596
Start position
61299447
Chromosome
11
Strand
Reverse

Ensembl gene ID
ENSG00000167986
HGNC ID
HGNC:2717
www.genenames.org
NCBI Gene ID
1642
UniProt ID
Q16531

  • Cytoplasm . Nucleus . Note=Primarily cytoplasmic (PubMed:10777491, PubMed:11673459). Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage (PubMed:10777491, PubMed:11673459). More concentrated in nuclei than in cytoplasm in germinal vesicle (GV) stage oocytes, zygotes and the 2-cell stage, but distributed in the cytoplasm at the MII-stage oocytes (By similarity). .
  • End piece
  • Mid piece
  • Nucleoplasm
  • Principal piece

Tissue specificity (tau)
0.698916
Expression inequality (Gini)
0.251718

Expression in transcripts per million

Adrenal Gland
234.56
Cells - Cultured fibroblasts
165.1
Testis
131.43
Ovary
126.56
Cells - EBV-transformed lymphocytes
122.7

Expression in transcripts per million

  • Adrenal Gland234.56
  • Cells - Cultured fibroblasts165.1
  • Testis131.43
  • Ovary126.56
  • Cells - EBV-transformed lymphocytes122.7
  • Nerve - Tibial100.42
  • Uterus100.11
  • Skin - Sun Exposed (Lower leg)97.15
  • Fallopian Tube95.76
  • Pituitary95.16
  • Cervix - Endocervix93.37
  • Bladder92.55
  • Skin - Not Sun Exposed (Suprapubic)90.84
  • Thyroid90.03
  • Artery - Tibial89.65
  • Muscle - Skeletal87.74
  • Brain - Cerebellar Hemisphere85.3
  • Cervix - Ectocervix83.8
  • Artery - Aorta83.29
  • Brain - Cerebellum81.94
  • Vagina80.06
  • Esophagus - Gastroesophageal Junction77.75
  • Adipose - Subcutaneous76.39
  • Breast - Mammary Tissue75.73
  • Esophagus - Muscularis74.72

And 29 more, listed on the interactive page.

Related records

Trials (1,854)

Drugs (5)