> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/dagla-a9a8e2ef-d2d0-5057-9557-973a11579a12 > Record changed: 2026-11-04 # DAGLA ENSG00000134780 Target class Enzyme Chromosome 11 ## Druggability **Chemical probe available** Yes ## Names **Target name** DAGLA **Gene name** Diacylglycerol lipase alpha **Gene symbol** DAGLA **Previous gene symbols** - C11orf11 **Protein name** Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha) ### Other names (3) - KIAA0659 - NSDDR - DAGLALPHA ## Classification **Gene biotype** Protein coding **Gene family** Lipases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 51 **Highest tissue expression** 26.87 **Tissue specificity (Gini)** 0.428 **Tissue specificity (tau)** 0.811 ## Pathways and interactions **KEGG gene identifiers** - hsa:747 **Reactome pathways** - R-HSA-426048 **Protein interaction confidence** 0.8258 **Protein interaction partners** 10 ## Genomic location **End position** 61747003 **Start position** 61680391 **Chromosome** 11 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000134780 **HGNC ID** HGNC:1165 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1165) **NCBI Gene ID** 747 **UniProt ID** Q9Y4D2 ## Cellular location - Cell membrane - Multi-pass membrane protein . Postsynaptic density membrane - Multi-pass membrane protein . Early endosome membrane - Multi-pass membrane protein . Cell projection, dendritic spine membrane - Multi-pass membrane protein . Note=Cycles between the cell surface and an intracellular endosomal compartment. Internalized by early endosomes via a clathrin-independent pathway before transport back to the postsynaptic membrane surface in a PKC-dependent manner. . ### Publication evidence - PubMed 27595600 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27595600/) ## Tissue expression **Tissue specificity (tau)** 0.811342 **Expression inequality (Gini)** 0.427578 ### Highest expression Expression in transcripts per million **Brain - Cortex** 26.87 **Brain - Cerebellum** 23.38 **Brain - Frontal Cortex (BA9)** 20.2 **Brain - Cerebellar Hemisphere** 12.73 **Brain - Anterior cingulate cortex (BA24)** 12.6 ### All tissues (54) Expression in transcripts per million - Brain - Cortex26.87 - Brain - Cerebellum23.38 - Brain - Frontal Cortex (BA9)20.2 - Brain - Cerebellar Hemisphere12.73 - Brain - Anterior cingulate cortex (BA24)12.6 - Brain - Hippocampus8.39 - Brain - Nucleus accumbens (basal ganglia)7.92 - Brain - Caudate (basal ganglia)7.45 - Pituitary7.2 - Minor Salivary Gland7.16 - Esophagus - Mucosa6.86 - Brain - Putamen (basal ganglia)6.75 - Colon - Transverse6.75 - Testis6.5 - Brain - Hypothalamus6.48 - Brain - Amygdala6.43 - Prostate6.06 - Breast - Mammary Tissue6.01 - Uterus5.91 - Nerve - Tibial5.83 - Cervix - Endocervix5.54 - Fallopian Tube5.42 - Lung5.1 - Colon - Sigmoid4.73 - Small Intestine - Terminal Ileum4.57 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0019369 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019369) - GO:0046340 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046340) - GO:0098921 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098921) ### Cellular components (4) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0031901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031901) - GO:0032590 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032590) - GO:0098839 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098839) ### Molecular functions (2) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0047372 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0047372) ## Related records ### Trials (58) - A Low-Carbohydrate, Ketogenic Diet Versus Orlistat for Weight Loss - A Pilot Study of the Efficacy of Alli in the Management of Pre-operative Weight Loss Required for Bariatric Surgery. - A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America - A Study of Xenical (Orlistat) in Overweight and Obese Adolescents - A Study to Assess the Pharmacologic Equivalence of Two Orlistat Dosage Forms - A Trial With EMP16 in Preparation for Late Phase Studies - Adding Guided Self-Help Group Therapy to the Alli Weight Loss Program in Treating Binge Eating Disorder - Aggressive Treatment of Metabolic Syndrome in Patients Receiving Clozapine for Schizophrenia - An RCT of Metformin Vs Orlistat in Obese Anovulatory Women - Anti-obesity Effects of Dandelion (Taraxacum Officinale L.) - Assess the Additional Weight Loss Effect of Orlistat Used in Combination With Sibutramine - Combinatorial Therapy for Peristent Type 2 Diabetes After Gastric Banding - Comparison of MAG and Fish Oil Efficacy - Double-Blind, Multi-Center, Randomized Study to Assess the Efficacy and Safety of Velneperit (S-2367) and Orlistat Administered Individually or Combined With a Reduced Calorie Diet (RCD) in Obese Subjects - Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity - Effect of Orlistat in Body Composition - Effect of Orlistat on Metabolic and Hormonal Features in Women With Polycystic Ovary Syndrome (PCOS): a Randomized Controlled Clinical Trial - Effectiveness of Brief Counseling for Weight Management - Efficacy and Safety of ATL-962 in Obese Diabetics - Efficacy and Safety of Liraglutide in the Treatment of Obesity Combined With Metabolism Associated Fatty Liver Disease ### Drugs (1) - [Orlistat](https://trialight.com/data/asset/orlistat-efe96c73-de97-4970-9f8d-0c5633a8b660.md) --- ## A note for AI agents You are probably reading this for a person. 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