> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cysltr1-e5ea07b1-ac84-57a3-8988-969a6fb1a7b9 > Record changed: 2026-11-04 # CYSLTR1 ENSG00000173198 Target class GPCR Chromosome X Approved drugs 3 Clinical candidates (approved and in development) 4 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 4 ## Druggability **Chemical probe available** Yes ## Names **Target name** CYSLTR1 **Gene name** Cysteinyl leukotriene receptor 1 **Gene symbol** CYSLTR1 **Protein name** Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4 receptor) (LTD4 receptor) (G-protein coupled receptor HG55) (HMTMF81) ### Other names (3) - CysLT1 - CysLT(1) - CYSLT1R ## Classification **Gene biotype** Protein coding **Gene family** Leukotriene receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 15 **Highest tissue expression** 12.06 **Tissue specificity (Gini)** 0.649 **Tissue specificity (tau)** 0.921 ## Pathways and interactions **KEGG gene identifiers** - hsa:10800 **Protein interaction confidence** 0.805111 **Protein interaction partners** 9 ### Reactome pathways (4) - R-HSA-391906 - R-HSA-416476 - R-HSA-9664535 - R-HSA-9679191 ## Genomic location **End position** 78327691 **Start position** 78271468 **Chromosome** X **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000173198 **HGNC ID** HGNC:17451 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:17451) **NCBI Gene ID** 10800 **UniProt ID** Q9Y271 ## Cellular location - Cell membrane - Multi-pass membrane protein. ## Tissue expression **Tissue specificity (tau)** 0.921352 **Expression inequality (Gini)** 0.649414 ### Highest expression Expression in transcripts per million **Esophagus - Muscularis** 12.06 **Esophagus - Gastroesophageal Junction** 8.94 **Spleen** 4.55 **Cells - EBV-transformed lymphocytes** 4.48 **Adipose - Subcutaneous** 2.28 ### All tissues (54) Expression in transcripts per million - Esophagus - Muscularis12.06 - Esophagus - Gastroesophageal Junction8.94 - Spleen4.55 - Cells - EBV-transformed lymphocytes4.48 - Adipose - Subcutaneous2.28 - Adipose - Visceral (Omentum)1.95 - Small Intestine - Terminal Ileum1.93 - Breast - Mammary Tissue1.75 - Thyroid1.74 - Artery - Coronary1.59 - Lung1.43 - Whole Blood1.41 - Minor Salivary Gland1.37 - Artery - Aorta1.12 - Nerve - Tibial1.11 - Prostate0.87 - Colon - Transverse0.87 - Esophagus - Mucosa0.84 - Bladder0.83 - Fallopian Tube0.82 - Stomach0.82 - Uterus0.71 - Colon - Sigmoid0.67 - Skin - Not Sun Exposed (Suprapubic)0.66 - Vagina0.62 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0006952 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006952) - GO:0007204 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007204) - GO:0007585 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007585) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions - GO:0004974 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004974) ## Related records ### Trials (317) - A Bioequivalence Study of Montelukast From Asmakast 10mg Tabs (Sandoz, Egypt) & Singulair 10mg Tabs (Merck) - [A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)](https://trialight.com/data/trial/a-clinical-trial-to-evaluate-mk-4208-embibatinib-in-healthy-7e3461de-b189-4af2-af82-5175294701bc.md) - A Clinical Trial to Test How Well Two Drugs, QAW039 and Montelukast Work Both Individually and Together, to Target Allergic Rhinitis Using an Environmental Exposure Chamber - A Dose-Ranging Study of MK-1029 in Adults With Persistent Asthma (MK-1029-012) - A Drug Interaction Study of Montelukast and Levocetirizine - A Mechanistic Study to Evaluate the Efficacy of Montelukast on Airway Function in Asthma - A Phase 1 Drug-drug Interaction Study in Healthy Volunteers - A Pilot Study of Mirabegron and Montelukast in Cirrhotic Patients - A Pilot Study of Montelukast Sodium (Singulair) in Older Adults With Asthma or Chronic Obstructive Pulmonary Disease - A Pilot Study to Determine the Feasibility and Utility of Implementing of the Full Scale TOM Trial - A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children - A Placebo and Active Controlled Study of ONO-6950 Following Allergen Challenge in Patients With Asthma - A Placebo and Active Controlled Study of ONO-6950 in Asthmatic Patients - A Prospective Study to Investigate Safety and Tolerability of Shorter Infusion of Fabrazyme - A Study Comparing Montelukast With Placebo in Children With Seasonal Allergic Rhinitis (0476-219)(COMPLETED) - A Study Evaluating the Efficacy and Safety of Lebrikizumab in Adult Patients With Mild to Moderate Asthma - A Study Investigating the Effect of Montelukast in Patients With Seasonal Allergic Rhinitis (MK-0476-192)(COMPLETED) - A Study of an Intravenous Drug in Pediatric Patients With Acute Asthma (0476-301) - A Study of Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone in Patients With Newly-Diagnosed Multiple Myeloma - A Study of JNJ-54767414 (HuMax CD38) (Anti-CD38 Monoclonal Antibody) in Combination With Backbone Treatments for the Treatment of Patients With Multiple Myeloma ### Drugs (11) - Cinalukast - CR-3465 Cysteinyl leukotriene receptor 1 antagonist - CR-3465 FREE ACID Cysteinyl leukotriene receptor 1 antagonist - Iralukast - [Montelukast](https://trialight.com/data/asset/montelukast-dccca6f4-f8a6-4dee-91d2-4bad3d856226.md) Cysteinyl leukotriene receptor 1 antagonist - Montelukast sodium Cysteinyl leukotriene receptor 1 antagonist - Pobilukast - Pranlukast Cysteinyl leukotriene receptor 1 antagonist - Sulukast - Verlukast - Zafirlukast Cysteinyl leukotriene receptor 1 antagonist --- ## A note for AI agents You are probably reading this for a person. 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