> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/cyp3a7-b95ae39c-e17f-582c-b1a8-ce4c85b5db4e
> Record changed: 2026-10-13

# CYP3A7

ENSG00000160870

Target class

Enzyme

Chromosome

7

Approved drugs

2

Clinical candidates (approved and in development)

2

## Clinical evidence

**Approved drugs**

2

**Clinical candidates (approved and in development)**

2

## Druggability

**Chemical probe available**

No

## Names

**Target name**

CYP3A7

**Gene name**

Cytochrome P450 family 3 subfamily A member 7

**Gene symbol**

CYP3A7

**Protein name**

Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (Cytochrome P450-HFLA) (P450HLp2)

### Other names (2)

- CP37
- P450-HFLA

## Classification

**Gene biotype**

Protein coding

**Gene family**

Cytochrome P450 family 3

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

3

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

24.51

**Tissue specificity (Gini)**

0.881

**Tissue specificity (tau)**

0.992

## Pathways and interactions

**Reactome pathways**

- R-HSA-211981

**Protein interaction confidence**

0.876549

**Protein interaction partners**

51

### KEGG gene identifiers (2)

- hsa:100861540
- hsa:1551

## Genomic location

**End position**

99735196

**Start position**

99705036

**Chromosome**

7

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000160870

**HGNC ID**

HGNC:2640

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2640)

**NCBI Gene ID**

1551

**UniProt ID**

P24462

## Cellular location

- Endoplasmic reticulum membrane
- Peripheral membrane protein. Microsome membrane
- Peripheral membrane protein.
- Cytosol

### Publication evidence

- PubMed 2492179  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2492179/)

## Tissue expression

**Tissue specificity (tau)**

0.992109

**Expression inequality (Gini)**

0.881025

### Highest expression

Expression in transcripts per million

**Liver**

24.51

**Lung**

1.68

**Breast - Mammary Tissue**

1.6

**Kidney - Cortex**

0.69

**Prostate**

0.45

### All tissues (54)

Expression in transcripts per million

- Liver24.51
- Lung1.68
- Breast - Mammary Tissue1.6
- Kidney - Cortex0.69
- Prostate0.45
- Skin - Not Sun Exposed (Suprapubic)0.42
- Small Intestine - Terminal Ileum0.36
- Adrenal Gland0.34
- Minor Salivary Gland0.31
- Kidney - Medulla0.31
- Skin - Sun Exposed (Lower leg)0.3
- Esophagus - Muscularis0.3
- Pancreas0.27
- Uterus0.27
- Colon - Sigmoid0.27
- Bladder0.25
- Ovary0.24
- Colon - Transverse0.24
- Esophagus - Gastroesophageal Junction0.23
- Fallopian Tube0.23
- Nerve - Tibial0.19
- Vagina0.17
- Adipose - Visceral (Omentum)0.17
- Testis0.13
- Pituitary0.13

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (5)

- GO:0002933  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002933)
- GO:0006805  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006805)
- GO:0008202  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008202)
- GO:0008210  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008210)
- GO:0042573  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042573)

### Cellular components

- GO:0005789  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789)

### Molecular functions (9)

- GO:0004497  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004497)
- GO:0008395  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008395)
- GO:0008401  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008401)
- GO:0016712  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016712)
- GO:0019825  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019825)
- GO:0050649  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050649)
- GO:0062183  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0062183)
- GO:0101020  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0101020)
- GO:0101021  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0101021)

## Off-target safety

- regulation of transcription factor activity  
### Studies (2)

  - cell-based: LTEA\_HepaRG\_CYP3A7is one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of NR mediated metabolism/Undifferentiated hepatocyte.
  - cell-based: LTEA\_HepaRG\_CYP3A7is one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of NR mediated metabolism/Undifferentiated hepatocyte.  
### Biological samples

  - HepaRG, cell line  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)

## Related records

### Trials (859)

- "OK 2004 Study" (Only Kaletra 2004 Study): Study to Evaluate Suspending Nucleosides From Triple-Drug Therapy in HIV Subjects
- "The Once A Day Protease Inhibitor Regimens"
- 48-Week Study Of GW433908 And Ritonavir Or GW433908 Alone, Twice Daily In Pediatric Patients With HIV Infection
- A Bioavailability Study of Rifabutin and Lopinavir/Ritonavir in Healthy Adult Subjects
- A Bioequivalence Study of Darunavir, Emtricitabine, and Tenofovir Alafenamide, in the Presence of Cobicistat in Healthy Participants
- A Clinical Study Of An Investigational Regimen Including Marketed HIV Drugs In HIV-1 Pediatric Subjects Ages 2-18 Years
- A Clinical Trial Comparing the Efficacy of Darunavir/Ritonavir Monotherapy Versus a Triple Combination Therapy Containing Darunavir/Ritonavir and 2 Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in Patients With Undetectable Plasma HIV-1 RNA on Current Treatment
- A Comparison of Three Anti-HIV Drug Combinations Containing Saquinavir Soft Gelatin Capsules Used in HIV-1 Infected Patients
- A Comparison of Three Drug Combinations Containing Clarithromycin in the Treatment of Mycobacterium Avium Complex (MAC) Disease in Patients With AIDS
- A Comparison of Two Anti-HIV Drug Regimens for Youth Who Have Failed Prior Therapy
- A Decentralized, Randomized Phase 2 Efficacy and Safety Study of Nirmatrelvir/Ritonavir in Adults with Long COVID.
- A Dose Ranging Study Of GW640385 Boosted With Ritonavir (Rtv) In Comparison To A RTV-Boosted Protease Inhibitor (PI) In HIV-1 Infected PI-Experienced Adults
- A Drug Interaction Study to Assess the Pharmacokinetics of Narlaprevir and Antiretroviral Drugs
- A Drug-drug Interaction (DDI) Study of Morphothiadine Mesilate/Ritonavir in Healthy Subjects
- A Drug-drug Interaction Study Between Daclatasvir and Atazanavir/Ritonavir or Atazanavir/Cobicistat
- A Drug-Drug Interaction Study Between Danoprevir/Low-Dose Ritonavir and Cyclosporine in Healthy Volunteers
- A Drug-Drug Interaction Study of Ketoconazole, Rifampicin and Ritonavir-Boosted Atazanavir With Single-Dose RO5093151 in Healthy Volunteers
- A First Time in Human Study to Assess the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of Single and Repeat Doses of GSK2485852 in Chronically Infected Hepatitis C Subjects
- A Follow up Study Designed to Obtain Long Term Data on Participants Who Either Achieved a Sustained Virologic Response or Did Not Achieve a Sustained Virologic Response in an AbbVie Sponsored Hepatitis C Study
- A Multi-centre, Double-blinded, Randomized, Placebo-controlled Trial on the Efficacy and Safety of Lopinavir / Ritonavir Plus Ribavirin in the Treatment of Severe Acute Respiratory Syndrome

### Drugs (2)

- Cobicistat Cytochrome P450 3A inhibitor
- [Ritonavir](https://trialight.com/data/asset/ritonavir-8662f393-091d-46b9-87cc-73f29dca2219.md) Cytochrome P450 3A inhibitor

---

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