> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cyp3a43-5dd89ca4-500d-5e7a-aaf3-cc36a8bd56e9 > Record changed: 2026-10-13 # CYP3A43 ENSG00000021461 Target class Enzyme Chromosome 7 Approved drugs 2 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** No ## Names **Target name** CYP3A43 **Gene name** Cytochrome P450 family 3 subfamily A member 43 **Gene symbol** CYP3A43 **Protein name** Cytochrome P450 3A43 (EC 1.14.14.1) ## Classification **Gene biotype** Protein coding **Gene family** Cytochrome P450 family 3 **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 3 **Protein localisation evidence grade** Approved **Highest tissue expression** 4.29 **Tissue specificity (Gini)** 0.648 **Tissue specificity (tau)** 0.959 ## Pathways and interactions **KEGG gene identifiers** - hsa:64816 ### Reactome pathways (2) - R-HSA-211958 - R-HSA-211981 ## Genomic location **End position** 99867305 **Start position** 99827922 **Chromosome** 7 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000021461 **HGNC ID** HGNC:17450 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:17450) **NCBI Gene ID** 64816 **UniProt ID** Q9HB55 ## Cellular location - Endoplasmic reticulum membrane - Peripheral membrane protein. Microsome membrane - Peripheral membrane protein. - Cytosol ## Tissue expression **Tissue specificity (tau)** 0.958878 **Expression inequality (Gini)** 0.648121 ### Highest expression Expression in transcripts per million **Liver** 4.29 **Testis** 1.77 **Pancreas** 1.47 **Prostate** 0.66 **Nerve - Tibial** 0.34 ### All tissues (54) Expression in transcripts per million - Liver4.29 - Testis1.77 - Pancreas1.47 - Prostate0.66 - Nerve - Tibial0.34 - Ovary0.3 - Brain - Cortex0.19 - Fallopian Tube0.19 - Breast - Mammary Tissue0.18 - Kidney - Medulla0.17 - Brain - Frontal Cortex (BA9)0.17 - Brain - Cerebellum0.16 - Adipose - Visceral (Omentum)0.15 - Uterus0.14 - Brain - Nucleus accumbens (basal ganglia)0.13 - Pituitary0.13 - Brain - Caudate (basal ganglia)0.13 - Brain - Cerebellar Hemisphere0.13 - Lung0.13 - Artery - Coronary0.13 - Minor Salivary Gland0.12 - Brain - Anterior cingulate cortex (BA24)0.12 - Spleen0.12 - Muscle - Skeletal0.11 - Artery - Aorta0.11 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:1903604 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903604) ### Cellular components - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) ### Molecular functions - GO:0004497 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004497) ## Related records ### Trials (859) - "OK 2004 Study" (Only Kaletra 2004 Study): Study to Evaluate Suspending Nucleosides From Triple-Drug Therapy in HIV Subjects - "The Once A Day Protease Inhibitor Regimens" - 48-Week Study Of GW433908 And Ritonavir Or GW433908 Alone, Twice Daily In Pediatric Patients With HIV Infection - A Bioavailability Study of Rifabutin and Lopinavir/Ritonavir in Healthy Adult Subjects - A Bioequivalence Study of Darunavir, Emtricitabine, and Tenofovir Alafenamide, in the Presence of Cobicistat in Healthy Participants - A Clinical Study Of An Investigational Regimen Including Marketed HIV Drugs In HIV-1 Pediatric Subjects Ages 2-18 Years - A Clinical Trial Comparing the Efficacy of Darunavir/Ritonavir Monotherapy Versus a Triple Combination Therapy Containing Darunavir/Ritonavir and 2 Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in Patients With Undetectable Plasma HIV-1 RNA on Current Treatment - A Comparison of Three Anti-HIV Drug Combinations Containing Saquinavir Soft Gelatin Capsules Used in HIV-1 Infected Patients - A Comparison of Three Drug Combinations Containing Clarithromycin in the Treatment of Mycobacterium Avium Complex (MAC) Disease in Patients With AIDS - A Comparison of Two Anti-HIV Drug Regimens for Youth Who Have Failed Prior Therapy - A Decentralized, Randomized Phase 2 Efficacy and Safety Study of Nirmatrelvir/Ritonavir in Adults with Long COVID. - A Dose Ranging Study Of GW640385 Boosted With Ritonavir (Rtv) In Comparison To A RTV-Boosted Protease Inhibitor (PI) In HIV-1 Infected PI-Experienced Adults - A Drug Interaction Study to Assess the Pharmacokinetics of Narlaprevir and Antiretroviral Drugs - A Drug-drug Interaction (DDI) Study of Morphothiadine Mesilate/Ritonavir in Healthy Subjects - A Drug-drug Interaction Study Between Daclatasvir and Atazanavir/Ritonavir or Atazanavir/Cobicistat - A Drug-Drug Interaction Study Between Danoprevir/Low-Dose Ritonavir and Cyclosporine in Healthy Volunteers - A Drug-Drug Interaction Study of Ketoconazole, Rifampicin and Ritonavir-Boosted Atazanavir With Single-Dose RO5093151 in Healthy Volunteers - A First Time in Human Study to Assess the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of Single and Repeat Doses of GSK2485852 in Chronically Infected Hepatitis C Subjects - A Follow up Study Designed to Obtain Long Term Data on Participants Who Either Achieved a Sustained Virologic Response or Did Not Achieve a Sustained Virologic Response in an AbbVie Sponsored Hepatitis C Study - A Multi-centre, Double-blinded, Randomized, Placebo-controlled Trial on the Efficacy and Safety of Lopinavir / Ritonavir Plus Ribavirin in the Treatment of Severe Acute Respiratory Syndrome ### Drugs (2) - Cobicistat Cytochrome P450 3A inhibitor - [Ritonavir](https://trialight.com/data/asset/ritonavir-8662f393-091d-46b9-87cc-73f29dca2219.md) Cytochrome P450 3A inhibitor --- ## A note for AI agents You are probably reading this for a person. 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