> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cyp3a4-4e8e5e2f-9da2-534c-bf28-f64be6725ac5 > Record changed: 2026-10-13 # CYP3A4 ENSG00000160868 Target class Enzyme Chromosome 7 Approved drugs 2 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** Yes ## Names **Target name** CYP3A4 **Gene name** Cytochrome P450 family 3 subfamily A member 4 **Gene symbol** CYP3A4 **Previous gene symbols** - CYP3A3 **Protein name** Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) ## Classification **Gene biotype** Protein coding **Gene family** Cytochrome P450 family 3 **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 7 **Protein localisation evidence grade** Approved **Highest tissue expression** 335.3 **Tissue specificity (Gini)** 0.96 **Tissue specificity (tau)** 0.996 ## Pathways and interactions **KEGG gene identifiers** - hsa:1576 **Protein interaction confidence** 0.918991 **Protein interaction partners** 116 ### Reactome pathways (7) - R-HSA-211945 - R-HSA-211981 - R-HSA-5423646 - R-HSA-9027307 - R-HSA-9749641 - R-HSA-9754706 - R-HSA-9757110 ## Genomic location **End position** 99784274 **Start position** 99756959 **Chromosome** 7 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000160868 **HGNC ID** HGNC:2637 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2637) **NCBI Gene ID** 1576 **UniProt ID** P08684 ## Cellular location - Endoplasmic reticulum membrane - Single-pass membrane protein. Microsome membrane - Single-pass membrane protein. - Cytosol ### Publication evidence - PubMed 21576599 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21576599/) ## Tissue expression **Tissue specificity (tau)** 0.996407 **Expression inequality (Gini)** 0.960342 ### Highest expression Expression in transcripts per million **Liver** 335.3 **Small Intestine - Terminal Ileum** 48.25 **Pancreas** 2.41 **Skin - Sun Exposed (Lower leg)** 1.92 **Skin - Not Sun Exposed (Suprapubic)** 1.9 ### All tissues (54) Expression in transcripts per million - Liver335.3 - Small Intestine - Terminal Ileum48.25 - Pancreas2.41 - Skin - Sun Exposed (Lower leg)1.92 - Skin - Not Sun Exposed (Suprapubic)1.9 - Testis1.03 - Adrenal Gland1.01 - Pituitary0.77 - Brain - Cerebellum0.49 - Cells - EBV-transformed lymphocytes0.36 - Esophagus - Mucosa0.31 - Colon - Transverse0.27 - Brain - Cerebellar Hemisphere0.27 - Breast - Mammary Tissue0.24 - Nerve - Tibial0.24 - Ovary0.22 - Vagina0.22 - Minor Salivary Gland0.22 - Kidney - Cortex0.21 - Cervix - Ectocervix0.21 - Adipose - Visceral (Omentum)0.2 - Colon - Sigmoid0.19 - Muscle - Skeletal0.17 - Adipose - Subcutaneous0.16 - Uterus0.15 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (17) - GO:0002933 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002933) - GO:0006629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006629) - GO:0006706 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006706) - GO:0006805 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006805) - GO:0008202 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008202) - GO:0008209 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008209) - GO:0008210 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008210) - GO:0009822 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009822) - GO:0016098 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016098) - GO:0042178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042178) - GO:0042359 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042359) - GO:0042369 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042369) - GO:0042572 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042572) - GO:0042573 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042573) - GO:0042759 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042759) - GO:0046222 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046222) - GO:0070989 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070989) ### Cellular components (3) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0043231 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043231) ### Molecular functions (22) - GO:0004497 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004497) - GO:0005496 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005496) - GO:0005506 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005506) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008395 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008395) - GO:0008401 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008401) - GO:0016491 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016491) - GO:0016712 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016712) - GO:0019825 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019825) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0030343 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030343) - GO:0034875 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034875) - GO:0050591 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050591) - GO:0050649 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050649) - GO:0062181 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0062181) - GO:0062187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0062187) - GO:0062188 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0062188) - GO:0062189 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0062189) - GO:0070576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070576) - GO:0101020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0101020) - GO:0101021 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0101021) - GO:0102320 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0102320) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ADME\_hCYP3A4, is one of one assay component(s) measured or calculated from the NVS\_ADME\_hCYP3A4 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - regulation of transcription factor activity ### Studies (2) - cell-based: LTEA\_HepaRG\_CYP3A4is one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of NR mediated metabolism. - cell-based: LTEA\_HepaRG\_CYP3A4is one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of NR mediated metabolism. ### Biological samples - HepaRG, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (859) - "OK 2004 Study" (Only Kaletra 2004 Study): Study to Evaluate Suspending Nucleosides From Triple-Drug Therapy in HIV Subjects - "The Once A Day Protease Inhibitor Regimens" - 48-Week Study Of GW433908 And Ritonavir Or GW433908 Alone, Twice Daily In Pediatric Patients With HIV Infection - A Bioavailability Study of Rifabutin and Lopinavir/Ritonavir in Healthy Adult Subjects - A Bioequivalence Study of Darunavir, Emtricitabine, and Tenofovir Alafenamide, in the Presence of Cobicistat in Healthy Participants - A Clinical Study Of An Investigational Regimen Including Marketed HIV Drugs In HIV-1 Pediatric Subjects Ages 2-18 Years - A Clinical Trial Comparing the Efficacy of Darunavir/Ritonavir Monotherapy Versus a Triple Combination Therapy Containing Darunavir/Ritonavir and 2 Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in Patients With Undetectable Plasma HIV-1 RNA on Current Treatment - A Comparison of Three Anti-HIV Drug Combinations Containing Saquinavir Soft Gelatin Capsules Used in HIV-1 Infected Patients - A Comparison of Three Drug Combinations Containing Clarithromycin in the Treatment of Mycobacterium Avium Complex (MAC) Disease in Patients With AIDS - A Comparison of Two Anti-HIV Drug Regimens for Youth Who Have Failed Prior Therapy - A Decentralized, Randomized Phase 2 Efficacy and Safety Study of Nirmatrelvir/Ritonavir in Adults with Long COVID. - A Dose Ranging Study Of GW640385 Boosted With Ritonavir (Rtv) In Comparison To A RTV-Boosted Protease Inhibitor (PI) In HIV-1 Infected PI-Experienced Adults - A Drug Interaction Study to Assess the Pharmacokinetics of Narlaprevir and Antiretroviral Drugs - A Drug-drug Interaction (DDI) Study of Morphothiadine Mesilate/Ritonavir in Healthy Subjects - A Drug-drug Interaction Study Between Daclatasvir and Atazanavir/Ritonavir or Atazanavir/Cobicistat - A Drug-Drug Interaction Study Between Danoprevir/Low-Dose Ritonavir and Cyclosporine in Healthy Volunteers - A Drug-Drug Interaction Study of Ketoconazole, Rifampicin and Ritonavir-Boosted Atazanavir With Single-Dose RO5093151 in Healthy Volunteers - A First Time in Human Study to Assess the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of Single and Repeat Doses of GSK2485852 in Chronically Infected Hepatitis C Subjects - A Follow up Study Designed to Obtain Long Term Data on Participants Who Either Achieved a Sustained Virologic Response or Did Not Achieve a Sustained Virologic Response in an AbbVie Sponsored Hepatitis C Study - A Multi-centre, Double-blinded, Randomized, Placebo-controlled Trial on the Efficacy and Safety of Lopinavir / Ritonavir Plus Ribavirin in the Treatment of Severe Acute Respiratory Syndrome ### Drugs (3) - Cobicistat Cytochrome P450 3A inhibitor - [Ritonavir](https://trialight.com/data/asset/ritonavir-8662f393-091d-46b9-87cc-73f29dca2219.md) Cytochrome P450 3A inhibitor - Tabimorelin Cytochrome P450 3A4 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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