> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cyp2d6-f002a0d7-1a68-55ff-8a2f-9188c475f31d > Record changed: 2026-11-04 # CYP2D6 ENSG00000100197 Target class Enzyme Chromosome 22 ## Druggability **Chemical probe available** Yes ## Names **Target name** CYP2D6 **Gene name** Cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) **Gene symbol** CYP2D6 **Protein name** Cytochrome P450 2D6 (EC 1.14.14.-) (CYPIID6) (Cholesterol 25-hydroxylase) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase) ### Other names (4) - CPD6 - P450-DB1 - CYP2D - P450C2D ### Previous gene symbols (5) - CYP2DL1 - CYP2D7P2 - CYP2D7BP - CYP2D8P2 - CYP2D7AP ## Classification **Gene biotype** Protein coding **Gene family** Cytochrome P450 family 2 **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 48 **Protein localisation evidence grade** Approved **Highest tissue expression** 215.32 **Tissue specificity (Gini)** 0.728 **Tissue specificity (tau)** 0.986 ## Pathways and interactions **KEGG gene identifiers** - hsa:1565 **Protein interaction confidence** 0.909667 **Protein interaction partners** 48 ### Reactome pathways (6) - R-HSA-211935 - R-HSA-211958 - R-HSA-211981 - R-HSA-211999 - R-HSA-9027307 - R-HSA-9749641 ## Genomic location **End position** 42131236 **Start position** 42125962 **Chromosome** 22 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000100197 **HGNC ID** HGNC:2625 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2625) **NCBI Gene ID** 1565 **UniProt ID** P10635 ## Cellular location - Endoplasmic reticulum membrane - Peripheral membrane protein. Microsome membrane - Peripheral membrane protein. - Golgi apparatus ### Publication evidence - PubMed 21576599 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21576599/) ## Tissue expression **Tissue specificity (tau)** 0.986304 **Expression inequality (Gini)** 0.728107 ### Highest expression Expression in transcripts per million **Liver** 215.32 **Small Intestine - Terminal Ileum** 9.65 **Thyroid** 9.39 **Brain - Cerebellum** 8.94 **Pituitary** 8.91 ### All tissues (54) Expression in transcripts per million - Liver215.32 - Small Intestine - Terminal Ileum9.65 - Thyroid9.39 - Brain - Cerebellum8.94 - Pituitary8.91 - Testis8.39 - Brain - Cerebellar Hemisphere6.55 - Prostate5.78 - Ovary5.44 - Brain - Nucleus accumbens (basal ganglia)3.89 - Vagina3.85 - Nerve - Tibial3.82 - Skin - Not Sun Exposed (Suprapubic)3.55 - Kidney - Medulla3.54 - Cervix - Endocervix3.49 - Spleen3.46 - Uterus3.33 - Brain - Hypothalamus3.3 - Skin - Sun Exposed (Lower leg)3.13 - Cervix - Ectocervix3.03 - Esophagus - Mucosa3.02 - Brain - Caudate (basal ganglia)2.86 - Fallopian Tube2.83 - Minor Salivary Gland2.81 - Colon - Transverse2.68 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (13) - GO:0006805 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006805) - GO:0008202 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008202) - GO:0008210 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008210) - GO:0009804 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009804) - GO:0009820 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009820) - GO:0009822 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009822) - GO:0016098 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016098) - GO:0033076 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033076) - GO:0042178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042178) - GO:0042572 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042572) - GO:0042759 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042759) - GO:0070989 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070989) - GO:0090350 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090350) ### Cellular components (3) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) ### Molecular functions (7) - GO:0004497 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004497) - GO:0016491 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016491) - GO:0016712 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016712) - GO:0020037 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0020037) - GO:0062187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0062187) - GO:0062188 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0062188) - GO:0062189 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0062189) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ADME\_hCYP2D6, is one of one assay component(s) measured or calculated from the NVS\_ADME\_hCYP2D6 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (81) - A Clinical Study to Evaluate the Effects of Akkermansia Muciniphila and Berberine on Prediabetes Among Obese Subjects. - [A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)](https://trialight.com/data/trial/a-clinical-trial-to-evaluate-mk-4208-embibatinib-in-healthy-7e3461de-b189-4af2-af82-5175294701bc.md) - A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation - A Drug-Drug Interaction Study of Orforglipron (LY3502970) With Quinidine in Healthy Participants - A Drug-Drug Interaction Study to Evaluate the Effects of Itraconazole, Carbamazepine, Quinidine and Fluconazole on the Pharmacokinetics and Safety of EDP-323. - A Mechanistic Randomized Controlled Trial on the Cardiovascular Effect of Berberine - A Phase 1 Study Comparing AVP-786 With AVP-923 - A Phase 1, Drug Interaction Study Between AVP-786 and Paroxetine and Between AVP-786 and Duloxetine in Healthy Subjects - A Phase-1 Study to Assess the Pharmacokinetics, Safety and Tolerability of AVP-786 in Healthy Volunteers - [A Single and Multiple Ascending Doses, Relative Bioavailability, Food Effect, and Drug-Drug Interaction Study of NX-5948 in Healthy Volunteers](https://trialight.com/data/trial/a-single-and-multiple-ascending-doses-relative-e765be29-f034-4382-84c2-075c49a7d226.md) - A Study of Imlunestrant (LY3484356) in Female Healthy Participants - A Study to Assess the Effect of Voriconazole and Quinidine on the Pharmacokinetics of a Single Dose of Repotrectinib in Healthy Participants - A Study to Evaluate the Effect of Genotype on LY2216684 - A Study to Investigate the Effect of Food on Balcinrenone/Dapagliflozin Pharmacokinetics in Fed and Fasted State and Pharmacokinetics of Balcinrenone When Dosed With a P-gp Inhibitor in Healthy Participants. - A Study to Investigate the Pharmacokinetics of AZD2389 in Healthy Participants When Administered Alone and in Combination With Quinidine - Anti-platelet Effect of Berberine in Patients After Percutaneous Coronary Intervention - Assessment of the Efficacy, Safety, and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide \[d6-DM\]/Quinidine Sulfate \[Q\]) for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type - Assessment of the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type - Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) - Berberine as Adjuvant Treatment for Schizophrenia Patients ### Drugs (2) - Berberine - [Quinidine](https://trialight.com/data/asset/quinidine-87aba552-7096-4212-a930-5c3f4b7ce394.md) --- ## A note for AI agents You are probably reading this for a person. 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