> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cyp19a1-9682b33b-ed66-55a7-8155-bf00584059c7 > Record changed: 2026-10-13 # CYP19A1 ENSG00000137869 Target class Enzyme Chromosome 15 Approved drugs 5 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 5 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** Yes ## Names **Target name** CYP19A1 **Gene name** Cytochrome P450 family 19 subfamily A member 1 **Gene symbol** CYP19A1 **Previous gene symbols** - CYP19 **Protein name** Aromatase (EC 1.14.14.14) (CYPXIX) (Cytochrome P-450AROM) (Cytochrome P450 19A1) (Estrogen synthase) ### Other names (6) - ARO - P-450AROM - CPV1 - ARO1 - CYAR - aromatase ## Classification **Gene biotype** Protein coding **Gene family** Cytochrome P450 family 19|MicroRNA protein coding host genes **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 5 **Protein localisation evidence grade** Uncertain **Highest tissue expression** 7.61 **Tissue specificity (Gini)** 0.751 **Tissue specificity (tau)** 0.956 ## Pathways and interactions **KEGG gene identifiers** - hsa:1588 **Protein interaction confidence** 0.883477 **Protein interaction partners** 65 ### Reactome pathways (3) - R-HSA-193144 - R-HSA-211976 - R-HSA-5579030 ## Genomic location **End position** 51338601 **Start position** 51208057 **Chromosome** 15 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000137869 **HGNC ID** HGNC:2594 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2594) **NCBI Gene ID** 1588 **UniProt ID** P11511 ## Cellular location - Endoplasmic reticulum membrane - Multi-pass membrane protein . Microsome membrane - Multi-pass membrane protein . ### Publication evidence - PubMed 2973313 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2973313/) ## Tissue expression **Tissue specificity (tau)** 0.955743 **Expression inequality (Gini)** 0.751142 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 7.61 **Nerve - Tibial** 3.42 **Testis** 2.67 **Adipose - Subcutaneous** 2.18 **Thyroid** 1 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts7.61 - Nerve - Tibial3.42 - Testis2.67 - Adipose - Subcutaneous2.18 - Thyroid1 - Ovary0.75 - Artery - Coronary0.72 - Skin - Sun Exposed (Lower leg)0.47 - Bladder0.47 - Artery - Tibial0.39 - Adrenal Gland0.35 - Adipose - Visceral (Omentum)0.35 - Breast - Mammary Tissue0.34 - Cervix - Endocervix0.34 - Spleen0.31 - Artery - Aorta0.28 - Cervix - Ectocervix0.28 - Heart - Atrial Appendage0.28 - Vagina0.27 - Skin - Not Sun Exposed (Suprapubic)0.26 - Minor Salivary Gland0.24 - Brain - Spinal cord (cervical c-1)0.23 - Lung0.23 - Fallopian Tube0.21 - Esophagus - Muscularis0.19 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0006694 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006694) - GO:0006703 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006703) - GO:0006710 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006710) - GO:0016125 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016125) - GO:2000866 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000866) ### Cellular components (3) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (7) - GO:0008395 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008395) - GO:0009055 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009055) - GO:0016712 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016712) - GO:0019825 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019825) - GO:0020037 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0020037) - GO:0070330 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070330) - GO:0101021 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0101021) ## On-target safety - Reduction, Cumulative fecundity and spawning ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/123) - Decreased fertility, Reduced number of oocytes ovulated ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/153) - irregularities, ovarian cycle ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/7) - impaired, Fertility ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/7) - Decrease, Population growth rate ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based ### Biological samples - ovary growing follicle Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/346) - Decrease, Population growth rate ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/123) - Reduction, Cumulative fecundity and spawning ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/122) - Decrease, Population growth rate ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/122) - Decrease, Population growth rate ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based ### Biological samples - ovary growing follicle Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/25) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ADME\_hCYP19A1, is one of one assay component(s) measured or calculated from the NVS\_ADME\_hCYP19A1 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - regulation of transcription factor activity ### Studies - cell-based: TOX21\_Aromatase\_Inhibition, is one of one assay component(s) measured or calculated from the TOX21\_Aromatase\_Inhibition assay. It is designed to make measurements of luciferase induction, a form of inducible reporter, as detected with bioluminescence signals by luciferase-coupled ATP quantitation technology. ### Biological samples - MCF-7, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (1,115) - 1st Line Treatment of Bevacizumab-Taxane vs Bevacizumab-Exemestane in Metastatic Breast Cancer - 3 Years of Anastrozole vs. no Treatment as Extended Adjuvant Therapy for Postmenopausal Women With Breast Cancer - 4EVER - Efficacy, Safety, Health Economics, Translational Research of Postmenopausal Women With Estrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer - A 2-Week Ketogenic Diet in Combination With Letrozole to Modulate PI3K Signaling in ER+ Breast Cancer - A 5-treatment, Study in Healthy Volunteers to Assess The Safety, Tolerability, and Pharmacokinetics of Four Controlled Release (CR) Pregabalin Tablet Formulations and the Immediate Release (IR) Formulation Administered Fasted - A Clinical Study of Darcilil Combined With AI Combined With Pyrrotinib in the Treatment of TPBC - A Clinical Study of HRS-6209 Combined With Other Treatment Regimens in Patients With Breast Cancer - A Clinical Study to Evaluate the Safety and Efficacy of JHM03 in Adult Patients With Upper Limb Spasticity - A Clinical Trial Assessing Efficacy and Safety of Sunitinib and Exemestane in Patients With ER \[Estrogen Receptor\] + and/or PgR \[Progesterone Receptor\] + Breast Cancer - A Clinical Trial to Compare Efficacy and Tolerability of Atorvastatin in Addition to Endocrine Treatment With Focus on Mechanisms of Resistance to Endocrine Treatment (Fulvestrant/Aromatase Inhibitors) in Patients With Advanced Breast Cancer - A Clinical Trial to Compare Efficacy and Tolerability of Faslodex With Arimidex in Patients With Advanced Breast Cancer - A Companion Sample Collection Protocol to Support the Discovery of Breast Cancer Aberrations With Treatment of CDK4/6 Therapy/LEE011/Ribociclib - A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease - A Comparison of Letrozole and Clomifene Citrate - A Dose Escalation Study Evaluating the Safety and Tolerability of GDC-0032 in Participants With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin's Lymphoma (NHL) and in Combination With Endocrine Therapy in Locally Advanced or Metastatic Hormone Receptor-Positive Breast Cancer - A Global Study to Compare the Effects of Fulvestrant and Arimidex in a Subset of Patients With Breast Cancer. - A Neoadjuvant Study of Abemaciclib (LY2835219) in Postmenopausal Women With Hormone Receptor Positive, HER2 Negative Breast Cancer - A New Oral Treatment For Type II Diabetes Mellitus - A Non-Interventional Study With Aromasin® As Adjuvant Treatment Of Invasive Early Breast Cancer - A Open Study of Metronomic Oral Vinorelbine in Combination With Aromatase Inhibitors for the Treatment of Postmenopausal Women With Hormone Receptor Positive,HER2-negative, Advanced Breast Cancer Who Received no Prior Therapy for Advanced Disease ### Drugs (6) - Aminoglutethimide Cytochrome P450 19A1 inhibitor - [Anastrozole](https://trialight.com/data/asset/anastrozole-327e05a9-e5b7-41d1-a335-bd8a46453b55.md) Cytochrome P450 19A1 inhibitor - [Exemestane](https://trialight.com/data/asset/exemestane-367c47e6-e892-496e-bbb5-5b4926a3c31a.md) Cytochrome P450 19A1 inhibitor - Fadrozole Cytochrome P450 19A1 inhibitor - [Letrozole](https://trialight.com/data/asset/letrozole-67319198-7e88-4130-b185-d776c835863c.md) Cytochrome P450 19A1 inhibitor - Testolactone Cytochrome P450 19A1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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