> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cyp17a1-593c155a-0d40-55ab-829f-9468945d0fdf > Record changed: 2026-10-13 # CYP17A1 ENSG00000148795 Target class Enzyme Chromosome 10 Approved drugs 2 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** No ## Names **Target name** CYP17A1 **Gene name** Cytochrome P450 family 17 subfamily A member 1 **Gene symbol** CYP17A1 **Previous gene symbols** - CYP17 **Protein name** Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase) ### Other names (3) - P450C17 - CPT7 - S17AH ## Classification **Gene biotype** Protein coding **Gene family** Cytochrome P450 family 17 **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 19 **Protein localisation evidence grade** Approved **Highest tissue expression** 6,921.5 **Tissue specificity (Gini)** 0.976 **Tissue specificity (tau)** 1 ## Pathways and interactions **KEGG gene identifiers** - hsa:1586 **Protein interaction confidence** 0.907896 **Protein interaction partners** 48 ### Reactome pathways (3) - R-HSA-193048 - R-HSA-194002 - R-HSA-5579028 ## Genomic location **End position** 102837501 **Start position** 102830461 **Chromosome** 10 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000148795 **HGNC ID** HGNC:2593 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2593) **NCBI Gene ID** 1586 **UniProt ID** P05093 ## Cellular location - Endoplasmic reticulum membrane . Microsome membrane . - Vesicles ### Publication evidence - PubMed 2808364 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2808364/) ## Tissue expression **Tissue specificity (tau)** 0.999797 **Expression inequality (Gini)** 0.976277 ### Highest expression Expression in transcripts per million **Adrenal Gland** 6,921.5 **Testis** 14.57 **Thyroid** 6.31 **Kidney - Medulla** 4.73 **Kidney - Cortex** 4.72 ### All tissues (54) Expression in transcripts per million - Adrenal Gland6,921.5 - Testis14.57 - Thyroid6.31 - Kidney - Medulla4.73 - Kidney - Cortex4.72 - Nerve - Tibial2.43 - Fallopian Tube2.24 - Ovary2.11 - Cervix - Ectocervix2.11 - Liver1.95 - Brain - Cerebellum1.93 - Brain - Cerebellar Hemisphere1.62 - Cervix - Endocervix1.59 - Artery - Aorta1.38 - Artery - Tibial1.32 - Muscle - Skeletal1.3 - Artery - Coronary1.26 - Uterus1.21 - Vagina1 - Prostate0.94 - Pituitary0.92 - Stomach0.9 - Breast - Mammary Tissue0.87 - Lung0.84 - Spleen0.81 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0006694 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006694) - GO:0006702 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006702) - GO:0006704 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006704) - GO:0007548 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007548) - GO:0008202 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008202) - GO:0034651 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034651) - GO:0042446 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042446) - GO:0042448 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042448) ### Cellular components - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) ### Molecular functions (3) - GO:0004508 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004508) - GO:0019825 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019825) - GO:0020037 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0020037) ## Related records ### Trials (389) - 177Lu-PSMA-I&T for Metastatic Castration-Resistant Prostate Cancer - 1911GCCC: Galeterone With Gemcitabine for Patients With Metastatic Pancreatic Adenocarcinoma - 3-arm Study of Abiraterone Acetate Alone, Abiraterone Acetate Plus Degarelix, a GnRH Antagonist, and Degarelix Alone for Patients With Prostate Cancer With a Rising PSA or a Rising PSA and Nodal Disease Following Definitive Radical Prostatectomy - A 2 Part, Phase 2 Trial of Galeterone in the Treatment of Castration Resistant Prostate Cancer - [A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)](https://trialight.com/data/trial/a-clinical-study-of-ifinatamab-deruxtecan-based-treatment-99be48a0-44f7-46eb-bdf5-d3d2adc6018e.md) - A Clinical Study of QLC5508 and/or QLH12016 in Combination With Other Anti-tumor Therapies in Subjects With Advanced Prostate Cancer - A Comparative Dose-finding Study of RS-113 in Patients With Metastatic Castration-resistant Prostate Cancer - A Comparative Study of Bioavailability of 3 New Abiraterone Acetate Tablets With Current Commercial Tablet - A Drug-Drug Interaction Study of Abiraterone Acetate Plus Prednisone With Dextromethorphan and Theophylline in Patients With Metastatic Castration-Resistant Prostate Cancer - A Multi-Center Trial of Androgen Suppression With Abiraterone Acetate, Leuprolide, PARP Inhibition and Stereotactic Body Radiotherapy in Prostate Cancer - A Multi-centre Study to Assess the Safety, Tolerability, and Pharmacokinetics of Capivasertib (AZD5363) in Combination With Novel Agents in Patients With Metastatic Prostate Cancer - A Multicenter Phase I/II Trial of Abiraterone Acetate + BEZ235 in Metastatic, Castration-Resistant Prostate Cancer - A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Study of Fuzuloparib Combined With Abiraterone Acetate and Prednisone (AA-P) Versus Placebo Combined With AA-P as First-Line Treatment in Patients With Metastatic Castration-Resistant Prostate Cancer - A Novel Insight Into CRPC Progression and Immune: Evidence From Single-cell Spatial Transcriptome Multi-omics - A Pharmacokinetic Study of Abiraterone Acetate in Male Participants With Impaired Renal Function Compared to Individuals With Normal Renal Function - A Pharmacokinetics Study to Assess Abiraterone Acetate Capsule and Tablet Formulations in Patients With Prostate Cancer - A Phase 1 Clinical Study of AZD4635 in Patients With Advanced Solid Malignancies - [A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors](https://trialight.com/data/trial/a-phase-1-2a-study-of-db-1311-bnt324-in-advanced-metastatic-b09e4d50-e189-4c38-848b-2e45efa5d49d.md) - A Phase 1/2a Study of the 2S,4R Enantiomer of Ketoconazole in Subjects With Type 2 Diabetes Mellitus - A Phase 2 Study to Evaluate Safety and Efficacy of Abiraterone Acetate in Male Participants With Prostate Cancer ### Drugs (6) - Abiraterone Cytochrome P450 17A1 inhibitor - [Abiraterone acetate](https://trialight.com/data/asset/abiraterone-acetate-2c6662c6-31e9-49ed-a022-f76f326fbd3e.md) Cytochrome P450 17A1 inhibitor - Galeterone Cytochrome P450 17A1 inhibitor - [Levoketoconazole](https://trialight.com/data/asset/levoketoconazole-2a0d3bb3-2041-43ef-88c8-8cf814b51e4c.md) Cytochrome P450 17A1 inhibitor - Orteronel Cytochrome P450 17A1 inhibitor - Seviteronel Cytochrome P450 17A1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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