> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cyp11b2-a697aaba-f90f-5afc-8916-609c5358a8db > Record changed: 2026-10-13 # CYP11B2 ENSG00000179142 Target class Enzyme Chromosome 8 Approved drugs 1 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** Yes ## Names **Target name** CYP11B2 **Gene name** Cytochrome P450 family 11 subfamily B member 2 **Gene symbol** CYP11B2 **Previous gene symbols** - CYP11B **Protein name** Cytochrome P450 11B2, mitochondrial (Aldosterone synthase) (ALDOS) (Aldosterone-synthesizing enzyme) (CYPXIB2) (Corticosterone 18-monooxygenase, CYP11B2) (EC 1.14.15.5) (Cytochrome P-450Aldo) (Cytochrome P-450C18) (Steroid 11-beta-hydroxylase, CYP11B2) (EC 1.14.15.4) (Steroid 18-hydroxylase) ### Other names (5) - CYP11BL - CPN2 - P-450C18 - P450aldo - ALDOS ## Classification **Gene biotype** Protein coding **Gene family** Cytochrome P450 family 11 **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 1 **Protein localisation evidence grade** Approved **Highest tissue expression** 89.37 **Tissue specificity (Gini)** 0.981 **Tissue specificity (tau)** 1 ## Pathways and interactions **KEGG gene identifiers** - hsa:1585 **Protein interaction confidence** 0.893676 **Protein interaction partners** 34 ### Reactome pathways (4) - R-HSA-193993 - R-HSA-194002 - R-HSA-211976 - R-HSA-5579009 ## Genomic location **End position** 142917850 **Start position** 142910559 **Chromosome** 8 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000179142 **HGNC ID** HGNC:2592 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2592) **NCBI Gene ID** 1585 **UniProt ID** P19099 ## Cellular location - Mitochondrion inner membrane - Peripheral membrane protein . - Mitochondria ## Tissue expression **Tissue specificity (tau)** 0.999943 **Expression inequality (Gini)** 0.981308 ### Highest expression Expression in transcripts per million **Adrenal Gland** 89.37 **Testis** 0.19 **Cervix - Ectocervix** 0.04 **Spleen** 0.02 **Liver** 0.01 ### All tissues (54) Expression in transcripts per million - Adrenal Gland89.37 - Testis0.19 - Cervix - Ectocervix0.04 - Spleen0.02 - Liver0.01 - Brain - Caudate (basal ganglia)0.01 - Small Intestine - Terminal Ileum0 - Cells - Cultured fibroblasts0 - Breast - Mammary Tissue0 - Nerve - Tibial0 - Uterus0 - Brain - Cerebellar Hemisphere0 - Kidney - Medulla0 - Artery - Aorta0 - Adipose - Visceral (Omentum)0 - Thyroid0 - Pituitary0 - Kidney - Cortex0 - Brain - Frontal Cortex (BA9)0 - Brain - Cortex0 - Ovary0 - Prostate0 - Heart - Atrial Appendage0 - Brain - Substantia nigra0 - Vagina0 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (11) - GO:0002017 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002017) - GO:0003091 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003091) - GO:0006700 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006700) - GO:0006705 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006705) - GO:0016125 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016125) - GO:0032342 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032342) - GO:0032870 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032870) - GO:0034651 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034651) - GO:0035865 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035865) - GO:0055075 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055075) - GO:0055078 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055078) ### Cellular components (2) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0005743 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005743) ### Molecular functions (3) - GO:0004507 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004507) - GO:0008395 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008395) - GO:0020037 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0020037) ## Related records ### Trials (26) - A Phase 1/2a Study of the 2S,4R Enantiomer of Ketoconazole in Subjects With Type 2 Diabetes Mellitus - A Phase 2b Study of DIO-902 or DIO-902 Placebo in Addition to Metformin and Atorvastatin or Atorvastatin Placebo for Type 2 Diabetes - [A Study Comparing Ketoconazole Shampoo, 2% and Ketoconazole 2% Shampoo (RS) in the Treatment of Tinea Versicolor.](https://trialight.com/data/trial/a-study-comparing-ketoconazole-shampoo-2-and-ketoconazole-2-708721ea-a471-4fd6-b550-3faa4d4dbe1f.md) - A Study to Assess the Safety and Efficacy of Levoketoconazole in the Treatment of Endogenous Cushing's Syndrome. - Alternation in the Human Microbiome With Commonly Used Topical Medications - An Efficacy Study of a New Formulation of Ketoconazole 2% Cream in Patients With Tinea Pedis, Commonly Known as Athlete's Foot - Bioavailability of Levoketoconazole and Ketoconazole Tablets - Clinical Study to Evaluate the Therapeutic Equivalence of Ketoconazole Cream 2% in the Treatment of Tinea Pedis - Clobetasol Propionate 0.05% Shampoo in Association With Antifungal Shampoo in Scalp Seborrheic Dermatitis - Cytochrome P450 Inhibition to Decrease Dosage of Dasatinib for Chronic Myelogenous Leukemia - Hormonal Mechanisms of Sleep Restriction - Axis Study - Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal Women - ITT4 Intratesticular Hormonal Milieu in Man (ITT4) - Ketoconazole Foam 2% for the Treatment of Versicolor - Levoketoconazole Food Effect Study in Healthy Subjects - Mycological Efficacy and Safety of Ketoconazole 2% Shampoo With a Seven-Day Versus Three-Day Treatment Duration in Pityriasis Versicolor - Open Label Safety & Pharmacodynamic Study 24Wk w/DIO-902 Combo w/Metformin & Atorvastatin in T2DM Patients - Open-label Treatment in Cushing's Syndrome - Optimizing the Treatment of Toenail Onychomycosis Using a New Transdermal Patch Combined With Terbinafine/Ketoconazole - Safety and Efficacy of Ketoconazole 2% Foam in the Treatment of Pityrosporum Folliculitis ### Drugs (1) - [Levoketoconazole](https://trialight.com/data/asset/levoketoconazole-2a0d3bb3-2041-43ef-88c8-8cf814b51e4c.md) Cytochrome P450 11B2 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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