> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cyp11a1-c0ae9d4a-3522-5b58-9709-1a855f93a9bb > Record changed: 2026-10-13 # CYP11A1 ENSG00000140459 Target class Enzyme Chromosome 15 Approved drugs 3 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Other names** - P450SCC **Target name** CYP11A1 **Gene name** Cytochrome P450 family 11 subfamily A member 1 **Gene symbol** CYP11A1 **Previous gene symbols** - CYP11A **Protein name** Cholesterol side-chain cleavage enzyme, mitochondrial (EC 1.14.15.6) (CYPXIA1) (Cholesterol desmolase) (Cytochrome P450 11A1) (Cytochrome P450(scc)) ## Classification **Gene biotype** Protein coding **Gene family** Cytochrome P450 family 11 **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 37 **Highest tissue expression** 1,056.44 **Tissue specificity (Gini)** 0.929 **Tissue specificity (tau)** 0.996 ## Pathways and interactions **KEGG gene identifiers** - hsa:1583 **Protein interaction confidence** 0.867 **Protein interaction partners** 33 ### Reactome pathways (3) - R-HSA-196108 - R-HSA-211976 - R-HSA-5579026 ## Genomic location **End position** 74367680 **Start position** 74337746 **Chromosome** 15 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000140459 **HGNC ID** HGNC:2590 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2590) **NCBI Gene ID** 1583 **UniProt ID** P05108 ## Cellular location - Mitochondrion inner membrane - Peripheral membrane protein . Note=Localizes to the matrix side of the mitochondrion inner membrane. . ## Tissue expression **Tissue specificity (tau)** 0.996225 **Expression inequality (Gini)** 0.928691 ### Highest expression Expression in transcripts per million **Adrenal Gland** 1,056.44 **Ovary** 68.92 **Testis** 47.47 **Esophagus - Mucosa** 8.13 **Spleen** 6.45 ### All tissues (54) Expression in transcripts per million - Adrenal Gland1,056.44 - Ovary68.92 - Testis47.47 - Esophagus - Mucosa8.13 - Spleen6.45 - Nerve - Tibial5.72 - Pituitary3.69 - Fallopian Tube3.55 - Uterus3.49 - Cervix - Endocervix3.48 - Brain - Caudate (basal ganglia)3.15 - Breast - Mammary Tissue3.1 - Adipose - Subcutaneous2.84 - Brain - Putamen (basal ganglia)2.77 - Brain - Nucleus accumbens (basal ganglia)2.6 - Adipose - Visceral (Omentum)2.5 - Brain - Anterior cingulate cortex (BA24)2.16 - Brain - Amygdala2.15 - Brain - Cortex2.11 - Liver2.02 - Brain - Substantia nigra1.98 - Cervix - Ectocervix1.96 - Brain - Frontal Cortex (BA9)1.92 - Prostate1.79 - Brain - Hippocampus1.66 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0006700 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006700) - GO:0008203 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008203) - GO:0016125 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016125) - GO:0120178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0120178) ### Cellular components (2) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0005759 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005759) ### Molecular functions (3) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008386 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008386) - GO:0020037 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0020037) ## Related records ### Trials (38) - A Phase 1/2a Study of the 2S,4R Enantiomer of Ketoconazole in Subjects With Type 2 Diabetes Mellitus - A Phase 2b Study of DIO-902 or DIO-902 Placebo in Addition to Metformin and Atorvastatin or Atorvastatin Placebo for Type 2 Diabetes - A Phase II Study to Evaluate the Efficacy and Safety of Pembrolizumab in Combination With Mitotane in Patients With Advanced Adrenocortical Carcinoma - A Phase II Trial of Early Medical Adrenalectomy for "D0.5" Prostate Cancer - A Safety and Feasibility Study of Mitotane in Prostate Cancer - [A Study Comparing Ketoconazole Shampoo, 2% and Ketoconazole 2% Shampoo (RS) in the Treatment of Tinea Versicolor.](https://trialight.com/data/trial/a-study-comparing-ketoconazole-shampoo-2-and-ketoconazole-2-708721ea-a471-4fd6-b550-3faa4d4dbe1f.md) - A Study to Assess the Safety and Efficacy of Levoketoconazole in the Treatment of Endogenous Cushing's Syndrome. - Alternation in the Human Microbiome With Commonly Used Topical Medications - An Efficacy Study of a New Formulation of Ketoconazole 2% Cream in Patients With Tinea Pedis, Commonly Known as Athlete's Foot - Bioavailability of Levoketoconazole and Ketoconazole Tablets - Cisplatin-Based Chemotherapy and/or Surgery in Treating Young Patients With Adrenocortical Tumor - Clinical Study to Evaluate the Therapeutic Equivalence of Ketoconazole Cream 2% in the Treatment of Tinea Pedis - Clobetasol Propionate 0.05% Shampoo in Association With Antifungal Shampoo in Scalp Seborrheic Dermatitis - Cytochrome P450 Inhibition to Decrease Dosage of Dasatinib for Chronic Myelogenous Leukemia - Efficacy of Adjuvant Mitotane Treatment (ADIUVO) - Evaluation of the Efficacy of Addition of Progesterone to Standard Chemotherapy in Adrenocortical Carcinoma (ACC) - Hormonal Mechanisms of Sleep Restriction - Axis Study - Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal Women - IMC-A12 With Mitotane vs Mitotane Alone in Recurrent, Metastatic, or Primary ACC That Cannot Be Removed by Surgery - ITT4 Intratesticular Hormonal Milieu in Man (ITT4) ### Drugs (3) - Aminoglutethimide Cytochrome P450 11A1 inhibitor - [Levoketoconazole](https://trialight.com/data/asset/levoketoconazole-2a0d3bb3-2041-43ef-88c8-8cf814b51e4c.md) Cytochrome P450 11A1 inhibitor - Mitotane Cytochrome P450 11A1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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