> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cul4a-e258e883-4774-5319-a48e-25d3215b89ac > Record changed: 2026-10-13 # CUL4A ENSG00000139842 Target class Unclassified protein Chromosome 13 Approved drugs 4 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 4 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** No ## Names **Target name** CUL4A **Gene name** Cullin 4A **Gene symbol** CUL4A **Protein name** Cullin-4A (CUL-4A) ## Classification **Gene biotype** Protein coding **Gene family** Cullins|MicroRNA protein coding host genes **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Approved **Highest tissue expression** 65.56 **Tissue specificity (Gini)** 0.254 **Tissue specificity (tau)** 0.617 ## Pathways and interactions **KEGG gene identifiers** - hsa:8451 **Protein interaction confidence** 0.89413 **Protein interaction partners** 108 ### Reactome pathways (9) - R-HSA-110314 - R-HSA-5696394 - R-HSA-5696395 - R-HSA-5696400 - R-HSA-6781823 - R-HSA-6781827 - R-HSA-6782135 - R-HSA-6782210 - R-HSA-8951664 ## Genomic location **End position** 113267108 **Start position** 113208193 **Chromosome** 13 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000139842 **HGNC ID** HGNC:2554 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2554) **NCBI Gene ID** 8451 **UniProt ID** Q13619 ## Cellular location - Nucleoplasm ## Tissue expression **Tissue specificity (tau)** 0.616776 **Expression inequality (Gini)** 0.254493 ### Highest expression Expression in transcripts per million **Muscle - Skeletal** 65.56 **Cells - Cultured fibroblasts** 49.49 **Testis** 41.25 **Skin - Sun Exposed (Lower leg)** 37.4 **Cells - EBV-transformed lymphocytes** 36.77 ### All tissues (54) Expression in transcripts per million - Muscle - Skeletal65.56 - Cells - Cultured fibroblasts49.49 - Testis41.25 - Skin - Sun Exposed (Lower leg)37.4 - Cells - EBV-transformed lymphocytes36.77 - Nerve - Tibial36.52 - Cervix - Endocervix36.18 - Uterus36 - Cervix - Ectocervix35.69 - Adipose - Subcutaneous35.63 - Skin - Not Sun Exposed (Suprapubic)35.43 - Thyroid34.71 - Artery - Tibial34.55 - Fallopian Tube33.74 - Vagina33.26 - Esophagus - Gastroesophageal Junction32.32 - Bladder32.01 - Lung31.92 - Artery - Aorta31.9 - Esophagus - Muscularis31.85 - Colon - Sigmoid31.29 - Breast - Mammary Tissue31.26 - Artery - Coronary31.24 - Ovary31.15 - Prostate30.15 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (11) - GO:0000082 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000082) - GO:0006974 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006974) - GO:0007283 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007283) - GO:0016567 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016567) - GO:0034644 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034644) - GO:0042110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042110) - GO:0042254 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042254) - GO:0043161 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043161) - GO:0045732 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045732) - GO:0097193 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097193) - GO:0140627 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140627) ### Cellular components (5) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0031464 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031464) - GO:0080008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0080008) ### Molecular functions (4) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0031625 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031625) - GO:0061630 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061630) - GO:0160072 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160072) ## Related records ### Trials (1,854) - "Monoclonal Antibodies for Treatment of Multiple Myeloma. Emphasis on the CD38 Antibody Daratumumab " - \[Effects of Selected Statins on Cardiovascular Parameters in Healthy Volunteers\] - 1454GCC: Anti-PD-1 (MK-3475) and IMiD (Pomalidomide) Combination Immunotherapy in Relapsed/Refractory Multiple Myeloma - 2015-09: a Phase II Randomized, Open-label Study of Anti-signaling Lymphocytic Activation Molecule Monoclonal Antibody During Maintenance Therapy - 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy - 2017-03: A Single-Arm, Open-label Study of Anti-Signaling Lymphocytic Activation Molecule F7 (Anti-SLAMF7) Monoclonal Antibody (mAb) Therapy After Autologous Stem Cell Transplant in Patients With Multiple Myeloma - 5 mg Glipizide/500 mg Metformin Hydrochloride Tablets, Fasting - 5 mg Glipizide/500 mg Metformin Hydrochloride Tablets, Non-Fasting - 5-Azacytidine With Lenalidomide in Patients With High Risk Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML) - A 2 Stage Trial of Lenalidomide (REV) in Asymptomatic Ovarian Cancer Patients With Increasing CA 125 in Late Relapse - A Bioequivalence Study Comparing A Fixed Dose Combination Formulation Of Myrin P Forte That Contains Rifampicin, Isoniazid, Ethambutol And Pyrazinamide Per Tablet To An Equivalent Dose Of Single Drug Reference Preparations Of Similar Combination Following Oral Administration In Healthy Adults - A Clinical Study Comparing SG301 Plus Pomalidomide and Dexamethasone to Placebo Plus Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma Patients - A Clinical Study of Injectable IMM0306 in Combination With Lenalidomide - A Clinical Study to Test the Effects of Ruxolitinib And Thalidomide Combination for Patients With Myelofibrosis - A Clinical Trial of PGDM1400 and PGT121 and VRC07-523LS Monoclonal Antibodies in HIV-infected and HIV-uninfected Adults - A Clinical Trial to Evaluate the Efficacy and Safety of TQB3909 Tablets Versus Investigator's Choice in the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) - A Companion Study for Studies THAL-MM-003, CC-5013-MM-009, and CC-5013-MM-010 for Subjects With Multiple Myeloma - A Dose Escalation Study of Carfilzomib Taken With Thalidomide and Dexamethasone in Relapsed AL Amyloidosis - A Dose Escalation Study of Lenalidomide in Relapsed or Refractory B-cell Chronic Lymphocytic Leukemia - A Dose Escalation Study of the Combination of Lenalidomide (Revlimid®), Dexamethasone and Cyclophosphamide in Patients Refractory or Relapsing From Stable Disease With Multiple Myeloma ### Drugs (5) - Iberdomide CRL4(CRBN) E3 ubiquitin ligase modulator - [Lenalidomide](https://trialight.com/data/asset/lenalidomide-1e614dfb-efd0-4006-a121-30a97656c7a9.md) CRL4(CRBN) E3 ubiquitin ligase inhibitor; CRL4(CRBN) E3 ubiquitin ligase modulator - Lenalidomide hydrochloride monohydrate CRL4(CRBN) E3 ubiquitin ligase modulator - [Pomalidomide](https://trialight.com/data/asset/pomalidomide-8cab22f9-2d15-4e50-9ef9-334f56340121.md) CRL4(CRBN) E3 ubiquitin ligase inhibitor - Thalidomide CRL4(CRBN) E3 ubiquitin ligase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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