> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ctsc-9460a36c-a83b-5723-bbeb-37392b4baed6 > Record changed: 2026-10-13 # CTSC ENSG00000109861 Target class Enzyme Chromosome 11 Approved drugs 0 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** Yes ## Names **Other names** - DPP1 **Target name** CTSC **Gene name** Cathepsin C **Gene symbol** CTSC **Protein name** Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) \[Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)\] ### Previous gene symbols (2) - PLS - PALS ## Classification **Gene biotype** Protein coding **Gene family** Cathepsins **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 52 **Protein localisation evidence grade** Supported **Highest tissue expression** 104.9 **Tissue specificity (Gini)** 0.526 **Tissue specificity (tau)** 0.867 ## Pathways and interactions **KEGG gene identifiers** - hsa:1075 **Protein interaction confidence** 0.798 **Protein interaction partners** 11 ### Reactome pathways (4) - R-HSA-204005 - R-HSA-2132295 - R-HSA-5694530 - R-HSA-6798695 ## Genomic location **End position** 88359684 **Start position** 88265069 **Chromosome** 11 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000109861 **HGNC ID** HGNC:2528 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2528) **NCBI Gene ID** 1075 **UniProt ID** P53634 ## Cellular location - Lysosome . - Vesicles ### Publication evidence - PubMed 7665576 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7665576/) ## Tissue expression **Tissue specificity (tau)** 0.866615 **Expression inequality (Gini)** 0.526462 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 104.9 **Lung** 61.5 **Spleen** 57.09 **Cells - EBV-transformed lymphocytes** 52.89 **Adipose - Visceral (Omentum)** 38.35 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts104.9 - Lung61.5 - Spleen57.09 - Cells - EBV-transformed lymphocytes52.89 - Adipose - Visceral (Omentum)38.35 - Whole Blood30.01 - Adipose - Subcutaneous28.59 - Small Intestine - Terminal Ileum26.01 - Artery - Coronary24.31 - Nerve - Tibial21.08 - Colon - Transverse20.84 - Thyroid20.58 - Breast - Mammary Tissue20.31 - Bladder20.27 - Cervix - Endocervix19.91 - Vagina17.55 - Kidney - Medulla17.45 - Artery - Aorta17.38 - Kidney - Cortex16.13 - Esophagus - Mucosa15.48 - Fallopian Tube15.48 - Uterus14.92 - Cervix - Ectocervix14.9 - Adrenal Gland14.86 - Colon - Sigmoid12.81 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0006508 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006508) - GO:0006955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006955) ### Cellular components (9) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005764 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005764) - GO:0005788 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005788) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0030134 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030134) - GO:0031012 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031012) - GO:0033116 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033116) - GO:0035578 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035578) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (3) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008234 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008234) - GO:0008239 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008239) ## Related records ### Trials (18) - A Phase I Study to Assess PK of AZD7986 Alone & With Verapamil, Itraconazole or Diltiazem in Healthy Subjects - A Study of Brensocatib Following a Single Oral Administration in Participants With or Without Renal Impairment - A Study of the Absorption, Metabolism, and Excretion of \[14C\]-Brensocatib Following a Single Oral Administration in Healthy Male Participants - A Study of the Efficacy and Safety of Brensocatib in Adults With Moderate to Severe Hidradenitis Suppurativa (HS) - [A Study of the Efficacy and Safety of Brensocatib in Participants With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)](https://trialight.com/data/trial/a-study-of-the-efficacy-and-safety-of-brensocatib-in-7eebaaf6-87ca-420f-abab-c78d40df1233.md) - A Study of the Palatability and Acceptability of Different Brensocatib Oral Liquid Formulations in Healthy Participants - A Study of the Safety, Pharmacokinetics, and Pharmacodynamics of INS1007 in Healthy Japanese and Caucasian Participants - A Study to Assess Pharmacokinetics (PK) of Brensocatib Alone and With Multiple Doses of Rifampin or Esomeprozole in Healthy Participants - A Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib in Participants With Non-Cystic Fibrosis Bronchiectasis - A Study to Assess the Relative Bioavailability of Brensocatib Pediatric Oral Solution to Oral Tablets in Healthy Participants - A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Brensocatib Tablets in Adults With Cystic Fibrosis - A Study to Evaluate the Pharmacokinetics (PK) and Safety of a Single Dose of Brensocatib in Participants With Normal Hepatic Function and Participants With Hepatic Impairment - A Study to Investigate Effect of Clarithromycin, a Strong CYP3A4 Inhibitor, on Brensocatib Pharmacokinetics in Healthy Participants - A Study to Investigate the Effects of Brensocatib on QT Interval in Healthy Participants - An Expanded Access Study to Assess Brensocatib for Participants With Non-Cystic Fibrosis Bronchiectasis - Assessment of INS1007 in Participants With Non-Cystic Fibrosis Bronchiectasis - Single + Multiple Ascending Dose and Food Effect Study of AZD7986 in Healthy Volunteers, PK, PD and Safety Study - STOP-COVID19: Superiority Trial Of Protease Inhibition in COVID-19 ### Drugs (1) - [Brensocatib](https://trialight.com/data/asset/brensocatib-717d305e-e3c4-4e9b-aad2-a4c12dc5a7dd.md) Dipeptidyl peptidase I inhibitor --- ## A note for AI agents You are probably reading this for a person. 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