> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ctla4-ba502748-1564-5251-a6a1-96e2f7035fe9
> Record changed: 2026-10-13

# CTLA4

ENSG00000163599

Target class

Surface antigen

Chromosome

2

Approved drugs

2

Clinical candidates (approved and in development)

6

## Clinical evidence

**Approved drugs**

2

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

6

## Druggability

**Chemical probe available**

No

## Names

**Target name**

CTLA4

**Gene name**

Cytotoxic T-lymphocyte associated protein 4

**Gene symbol**

CTLA4

**Protein name**

Cytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) (CTLA-4) (CD antigen CD152)

### Other names (4)

- CD152
- CD
- GSE
- CTLA-4

### Previous gene symbols (2)

- CELIAC3
- IDDM12

## Classification

**Gene biotype**

Protein coding

**Gene family**

CD molecules|V-set domain containing

**Target class**

Surface antigen

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

10

**Highest tissue expression**

5.8

**Tissue specificity (Gini)**

0.621

**Tissue specificity (tau)**

0.892

## Pathways and interactions

**KEGG gene identifiers**

- hsa:1493

**Protein interaction confidence**

0.837743

**Protein interaction partners**

105

### Reactome pathways (3)

- R-HSA-389356
- R-HSA-389513
- R-HSA-8877330

## Genomic location

**End position**

203873965

**Start position**

203853888

**Chromosome**

2

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000163599

**HGNC ID**

HGNC:2505

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2505)

**NCBI Gene ID**

1493

**UniProt ID**

P16410

## Cellular location

- Cell membrane
- Single-pass type I membrane protein . Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalization. .

### Publication evidence (3)

- PubMed 18468488  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18468488/)
- PubMed 18641304  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18641304/)
- PubMed 28484017  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28484017/)

## Tissue expression

**Tissue specificity (tau)**

0.891574

**Expression inequality (Gini)**

0.620993

### Highest expression

Expression in transcripts per million

**Spleen**

5.8

**Small Intestine - Terminal Ileum**

4.93

**Lung**

4.35

**Testis**

2.53

**Whole Blood**

1.78

### All tissues (54)

Expression in transcripts per million

- Spleen5.8
- Small Intestine - Terminal Ileum4.93
- Lung4.35
- Testis2.53
- Whole Blood1.78
- Fallopian Tube1.22
- Adipose - Visceral (Omentum)1.05
- Colon - Transverse1.04
- Esophagus - Mucosa1.03
- Vagina1.01
- Breast - Mammary Tissue0.82
- Artery - Coronary0.77
- Prostate0.76
- Thyroid0.76
- Cervix - Endocervix0.74
- Kidney - Medulla0.73
- Skin - Not Sun Exposed (Suprapubic)0.71
- Nerve - Tibial0.68
- Artery - Aorta0.64
- Adipose - Subcutaneous0.63
- Bladder0.58
- Cervix - Ectocervix0.57
- Stomach0.53
- Minor Salivary Gland0.52
- Skin - Sun Exposed (Lower leg)0.39

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (8)

- GO:0006955  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006955)
- GO:0006974  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006974)
- GO:0030889  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030889)
- GO:0043065  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043065)
- GO:0045590  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045590)
- GO:0050853  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050853)
- GO:0050860  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050860)
- GO:0050868  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050868)

### Cellular components (6)

- GO:0005794  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0009897  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009897)
- GO:0045334  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045334)
- GO:0048471  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471)
- GO:0098636  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098636)

### Molecular functions (2)

- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0140319  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140319)

## Related records

### Trials (1,350)

- ......SMARTEST Trial......
- A 2-part Phase 1/2 Open-label Trial on ODM-212
- A BIOmarker Driven Trial With Nivolumab and Ipilimumab or VEGFR tKi in Naïve Metastatic Kidney Cancer
- A Biomarker Study in Advanced Mucosal or Acral Lentiginous Melanoma Receiving Nivolumab in Combination With Ipilimumab
- A Clinical Study Evaluating Nivolumab-containing Treatments in Patients With Advanced Non-small Cell Lung Cancer After Failing Previous PD-1/(L)1 Therapy and Chemotherapy
- A Clinical Study With Tremelimumab as Monotherapy in Malignant Mesothelioma
- A Clinical Trial of Durvalumab and Tremelimumab, Administered With Radiation Therapy or Ablation in Patients With Colorectal Cancer
- A Clinical Trial of Influenza Virus Split Vaccine for Individuals Aged 60 Years and Above
- A Clinical Trial: Adjuvant Low-dose Ipilimumab + Nivolumab After Resection of Melanoma Macrometastases
- A Combination of Ipilimumab and Fotemustine for Treat Unresectable Locally Advanced or Metastatic Melanoma
- A Companion Study for Patients Enrolled in Prior/Parent Ipilimumab Studies
- A Comparative Study in Chinese Subjects With Chemotherapy Naïve Stage IV Melanoma Receiving Ipilimumab (3 mg/kg) vs. Dacarbazine
- A DNAJB1-PRKACA Fusion Kinase Peptide Vaccine Combined With Glutamine Antagonist DRP-104, Nivolumab, and Ipilimumab in Patients With Advanced Stage Fibrolamellar Carcinoma (FLC)
- A Dose Escalation and Cohort Expansion Study of NKTR-214 in Combination With Nivolumab and Other Anti-Cancer Therapies in Patients With Select Advanced Solid Tumors
- A Dose Escalation and Combination Immunotherapy Study to Evaluate BMS-986226 Alone or in Combination With Nivolumab or Ipilimumab in Patients With Advanced Solid Tumors
- A Dose-Escalation Study of MDX-010 Administered Monthly as Immunotherapy in Subjects Infected With Human Immunodeficiency Virus (HIV)
- [A First-in-Human Study of BMS-986506 in Participants With Advanced Clear Cell Renal Cell Carcinoma (ccRCC)](https://trialight.com/data/trial/a-first-in-human-study-of-bms-986506-in-participants-with-562948f9-e1d4-4120-aadc-9540aba9790e.md)
- [A First-in-human, Dose Escalation and Dose Expansion Study of SAR445877 in Adult Participants With Advanced Solid Tumors](https://trialight.com/data/trial/a-first-in-human-dose-escalation-and-dose-expansion-study-of-02f45cf6-c625-4149-9e56-0457f52212b2.md)
- A Global Study to Assess the Effects of MEDI4736 (Durvalumab), Given as Monotherapy or in Combination With Tremelimumab Determined by PD-L1 Expression Versus Standard of Care in Patients With Locally Advanced or Metastatic Non Small Cell Lung Cancer
- A Longitudinal Assessment of Tumor Evolution in Patients With Brain Cancer

### Drugs (6)

- [Cadonilimab](https://trialight.com/data/asset/cadonilimab-3970701f-ffc8-4027-a97b-4e6c913803e6.md) Cytotoxic T-lymphocyte protein 4 inhibitor
- Erfonrilimab Cytotoxic T-lymphocyte protein 4 inhibitor
- [Ipilimumab](https://trialight.com/data/asset/ipilimumab-06c42b29-e333-4f3c-94fe-dbea5fe48cd4.md) Cytotoxic T-lymphocyte protein 4 inhibitor
- Quavonlimab Cytotoxic T-lymphocyte protein 4 inhibitor
- [Tremelimumab](https://trialight.com/data/asset/tremelimumab-24e58585-33c8-4837-b098-dae8de9e4d79.md) Cytotoxic T-lymphocyte protein 4 inhibitor
- Zalifrelimab Cytotoxic T-lymphocyte protein 4 inhibitor

---

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