> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/csnk2a1-3f512e39-8c51-58d9-8684-59bcb575d9a0 > Record changed: 2026-10-13 # CSNK2A1 ENSG00000101266 Target class Kinase Chromosome 20 Approved drugs 0 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 0 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** Yes ## Names **Target name** CSNK2A1 **Gene name** Casein kinase 2 alpha 1 **Gene symbol** CSNK2A1 **Protein name** Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) ### Other names (2) - Cka1 - Cka2 ## Classification **Gene biotype** Protein coding **Gene family** Casein kinase 2 alpha family **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 73.2 **Tissue specificity (Gini)** 0.207 **Tissue specificity (tau)** 0.603 ## Pathways and interactions **KEGG gene identifiers** - hsa:1457 **Protein interaction confidence** 0.831466 **Protein interaction partners** 73 ### Reactome pathways (15) - R-HSA-1483191 - R-HSA-201688 - R-HSA-2514853 - R-HSA-445144 - R-HSA-6804756 - R-HSA-6814122 - R-HSA-8934903 - R-HSA-8939243 - R-HSA-8948751 - R-HSA-9755511 - R-HSA-9768727 - R-HSA-9828806 - R-HSA-9929491 - R-HSA-9931529 - R-HSA-9931530 ## Genomic location **End position** 543835 **Start position** 472498 **Chromosome** 20 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000101266 **HGNC ID** HGNC:2457 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2457) **NCBI Gene ID** 1457 **UniProt ID** P68400 ## Cellular location - Nucleus . - Nucleoplasm ### Publication evidence (2) - PubMed 23123191 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23123191/) - PubMed 24962073 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24962073/) ## Tissue expression **Tissue specificity (tau)** 0.602779 **Expression inequality (Gini)** 0.206919 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 73.2 **Cells - Cultured fibroblasts** 60.96 **Testis** 43.56 **Uterus** 41.89 **Skin - Sun Exposed (Lower leg)** 41.61 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes73.2 - Cells - Cultured fibroblasts60.96 - Testis43.56 - Uterus41.89 - Skin - Sun Exposed (Lower leg)41.61 - Ovary41.53 - Cervix - Endocervix40.14 - Skin - Not Sun Exposed (Suprapubic)39.91 - Brain - Cerebellar Hemisphere39.66 - Cervix - Ectocervix39.25 - Bladder39.08 - Vagina39.03 - Fallopian Tube37.95 - Muscle - Skeletal37.02 - Esophagus - Mucosa36.16 - Thyroid35.88 - Artery - Tibial35.74 - Nerve - Tibial34.17 - Artery - Aorta33.19 - Brain - Cerebellum32.04 - Artery - Coronary31.95 - Colon - Sigmoid31.5 - Adrenal Gland31.49 - Lung31.09 - Prostate30.87 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (18) - GO:0006302 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006302) - GO:0006457 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006457) - GO:0006974 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006974) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0017148 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017148) - GO:0018105 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018105) - GO:0030177 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030177) - GO:0030307 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030307) - GO:0032435 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032435) - GO:0045732 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045732) - GO:0050821 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050821) - GO:0075342 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0075342) - GO:1901797 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1901797) - GO:1905337 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905337) - GO:1905818 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905818) - GO:2000042 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000042) - GO:2001234 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001234) ### Cellular components (8) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005956 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005956) - GO:0016605 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016605) - GO:0031519 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031519) - GO:0070822 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070822) ### Molecular functions (6) - GO:0004674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016301 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016301) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0051879 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051879) - GO:0106310 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106310) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ENZ\_hCK2a2b2, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hCK2a2b2 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (163) - [A Clinical Trial to Evaluate the Immunogenicity and Safety of Group ACYW135 Meningococcal Conjugate Vaccine (CRM197) in Adults Aged 18 to 55 Years](https://trialight.com/data/trial/a-clinical-trial-to-evaluate-the-immunogenicity-and-safety-b02dd49b-1c3f-4a50-9b06-8273912d6fc8.md) - A Clinical Trial to Evaluate the Reversibility of Abacavir/Lamivudine/Dolutegravir CNS-Related Neurotoxicity After Switching to Tenofovir/Alafenamide/Emtricitabine/Darunavir/Cobicistat (TAF/FTC/DRV/c) - A Drug Interaction Study of Cilnidipine and Valsartan - A Phase 1/2 Study of CAN04 in Combination With Different Chemotherapy Regimens in Subjects With Advanced Solid Tumors - A Phase I Study to Assess the Pharmacokinetics of GSK2798745 Tablets - A Phase I, Randomized, Modified Single-blind, Active-controlled (Infants Only), Four-stage, Step-down, Comparative, Multi-center Study - A Safety and Immunogenicity Study of 3 Doses of Opal Immunotherapy in HIV Infected People - A Sourcing Study to Collect Human Blood Samples From Healthy Adults - A Study in Healthy Men to Test if Taking Different Formulations of BI 1358894 With or Without Food Influences the Amount of BI 1358894 in the Blood - A Study of a Quadrivalent Meningococcal Tetanus Protein Conjugate Vaccine in Infants and Toddlers - A Study of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Evaluated as a Fixed Dose Combination Regimen in Participants Switching From an Integrase Inhibitor Who Have Experienced Rapid Weight Gain - A Study of LY3202626 in Healthy Participants and Participants With Alzheimer's Disease - A Study of Silmitasertib (CX-4945) in Healthy Subject - A Study to Evaluate Efficacy and Safety of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Fixed Dose Combination (FDC) Versus a Regimen Consisting of Darunavir/Cobicistat FDC With Emtricitabine/Tenofovir Disoproxil Fumarate FDC in Treatment-naive HIV Type 1 Infected Subjects - A Study to Evaluate Safety, Reactogenicity, and Immune Response of GVGH iNTS-TCV Vaccine Against Invasive Nontyphoidal Salmonella and Typhoid Fever - A Study to Evaluate the Safety and Immunogenicity of a Candidate Ebola Vaccine in Children - A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments - Adherence With Iron Sprinkles Among High-Risk Infants - Adjunctive Supplementation of Antioxidants (Vitamins E + C) Plus Omega-3 Fatty Acids - An Italian Observation of Antiretroviral Treatment in Participants Taking Darunavir/ Cobicistat Plus Emtricitabine and Tenofovir Alafenamide Fumarate ### Drugs (1) - [Silmitasertib](https://trialight.com/data/asset/silmitasertib-6e58fcc4-d42d-493a-ae85-003b29c7ea52.md) Casein kinase II alpha inhibitor --- ## A note for AI agents You are probably reading this for a person. 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