> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/csf1r-c39928ca-5d68-56f1-9abd-ca1dfee5c7ff > Record changed: 2026-10-13 # CSF1R ENSG00000182578 Target class Kinase Chromosome 5 Approved drugs 7 Clinical candidates (approved and in development) 20 ## Clinical evidence **Approved drugs** 7 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 20 ## Druggability **Chemical probe available** Yes ## Names **Target name** CSF1R **Gene name** Colony stimulating factor 1 receptor **Gene symbol** CSF1R **Previous gene symbols** - FMS **Protein name** Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115) ### Other names (3) - C-FMS - CSFR - CD115 ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|CD molecules|Immunoglobulin like domain containing **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 52 **Protein localisation evidence grade** Supported **Highest tissue expression** 206.87 **Tissue specificity (Gini)** 0.491 **Tissue specificity (tau)** 0.928 ## Pathways and interactions **KEGG gene identifiers** - hsa:1436 **Protein interaction confidence** 0.802641 **Protein interaction partners** 117 ### Reactome pathways (3) - R-HSA-449836 - R-HSA-8853884 - R-HSA-9680350 ## Genomic location **End position** 150113372 **Start position** 150053291 **Chromosome** 5 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000182578 **HGNC ID** HGNC:2433 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2433) **NCBI Gene ID** 1436 **UniProt ID** P07333 ## Cellular location - Cell membrane - Single-pass type I membrane protein. - Plasma membrane - Vesicles ## Tissue expression **Tissue specificity (tau)** 0.927965 **Expression inequality (Gini)** 0.491233 ### Highest expression Expression in transcripts per million **Spleen** 206.87 **Nerve - Tibial** 49.67 **Adipose - Subcutaneous** 38.03 **Lung** 37.92 **Adipose - Visceral (Omentum)** 34.34 ### All tissues (54) Expression in transcripts per million - Spleen206.87 - Nerve - Tibial49.67 - Adipose - Subcutaneous38.03 - Lung37.92 - Adipose - Visceral (Omentum)34.34 - Brain - Spinal cord (cervical c-1)33.67 - Artery - Coronary31.88 - Small Intestine - Terminal Ileum29.82 - Artery - Aorta29.58 - Whole Blood29.54 - Adrenal Gland25.48 - Brain - Substantia nigra21.62 - Bladder19.15 - Colon - Sigmoid18.24 - Breast - Mammary Tissue17.39 - Brain - Hypothalamus17.07 - Fallopian Tube17.06 - Artery - Tibial17.04 - Colon - Transverse16.07 - Stomach16.06 - Cervix - Endocervix15.49 - Esophagus - Gastroesophageal Junction15.45 - Prostate15.22 - Esophagus - Muscularis14.69 - Minor Salivary Gland14.16 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (20) - GO:0001934 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001934) - GO:0006954 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006954) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0008283 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008283) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0008360 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008360) - GO:0010759 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010759) - GO:0018108 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108) - GO:0019221 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221) - GO:0030097 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030097) - GO:0030224 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030224) - GO:0030225 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030225) - GO:0032722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032722) - GO:0036006 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036006) - GO:0045217 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045217) - GO:0046777 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046777) - GO:0060603 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060603) - GO:0061098 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061098) - GO:0120041 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0120041) - GO:2000147 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000147) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (4) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0005011 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005011) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019955) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ENZ\_hCSF1R, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hCSF1R assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (895) - (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors - (QuANTUM-R): An Open-label Study of Quizartinib Monotherapy vs. Salvage Chemotherapy in Acute Myeloid Leukemia (AML) Subjects Who Are FLT3-ITD Positive - \[18F\]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer - 12 Week Patient Study in Neovascular Age-related Macular Degeneration (AMD) - A Bioequivalence Study of Sunitinib Malate Capsules. - A BIOmarker Driven Trial With Nivolumab and Ipilimumab or VEGFR tKi in Naïve Metastatic Kidney Cancer - A Clinical Trial Assessing Efficacy and Safety of Sunitinib and Exemestane in Patients With ER \[Estrogen Receptor\] + and/or PgR \[Progesterone Receptor\] + Breast Cancer - A Clinical Trial Comparing Efficacy And Safety Of Sunitinib And Capecitabine - A Clinical Trial Comparing Efficacy And Safety Of Sunitinib Versus Placebo For TheTreatment Of Patients At High Risk Of Recurrent Renal Cell Cancer - A Clinical Trial to Assess the Efficacy and Safety of the Combination of a Drug Call Quizartinib With Chemotherapy (FLAG-IDA) in Patients With Acute Myeloid Leukemia That Has Not Responded to the First Treatment or That Has Returned After the First Treatment - A Combination Clinical Study of PLX3397 and Pembrolizumab To Treat Advanced Melanoma and Other Solid Tumors - A Combination of Pazopanib and Carboplatin in Advanced Solid Malignancies - A Comparison of Vorolanib Tablets Combined With Everolimus Versus Sunitinib in Patients With Advanced Renal Cell Carcinoma Who Have Progressed After Treatment With Immunotherapy Monotherapy or in Combination With TKI - A Continuation Study Using Sunitinib Malate For Patients Leaving Treatment On A Previous Sunitinib Study. - A CpG-methylation-based Assay for Stratifying Stage III Clear Cell Renal Cell Carcinoma of Receiving Adjuvant Treatment - A Dose-Escalation Study of ENMD-2076 Administered Orally to Patients With Advanced Cancer - A Long-term Study Evaluating Hepatotoxicity Associated With TURALIO™ (Pexidartinib) Treatment - A Multi-center, Open-label Study of Oral ENMD-2076 for the Treatment of Patients With Advanced Fibrolamellar Carcinoma - A Ph1b/2 Study of Axatilimab Monotherapy in Chinese Participants With Recurrent or Refractory cGVHD - A Pharmacokinetic Study to Access How the Body Absorbs and Removes Linifanib in Male Patients With Advanced Solid Tumors. ### Drugs (21) - AMG-820 Macrophage colony stimulating factor receptor inhibitor - ARRY-382 Macrophage colony stimulating factor receptor inhibitor - Axatilimab Macrophage colony stimulating factor receptor inhibitor - Cabiralizumab Macrophage colony stimulating factor receptor antagonist - CT-1578 Macrophage colony stimulating factor receptor inhibitor - Edicotinib Macrophage colony stimulating factor receptor inhibitor - Emactuzumab Macrophage colony stimulating factor receptor inhibitor - ENMD-2076 Macrophage colony stimulating factor receptor inhibitor - IMC-CS4 Macrophage colony stimulating factor receptor inhibitor - Linifanib Macrophage colony stimulating factor receptor inhibitor - Pazopanib Macrophage colony stimulating factor receptor inhibitor - Pazopanib hydrochloride Macrophage colony stimulating factor receptor inhibitor - Pexidartinib Macrophage colony stimulating factor receptor inhibitor - Pexidartinib hydrochloride Macrophage colony stimulating factor receptor inhibitor - PLX-5622 Macrophage colony stimulating factor receptor inhibitor - PLX-7486 Macrophage colony stimulating factor receptor inhibitor - [Quizartinib](https://trialight.com/data/asset/quizartinib-6da82f4e-69c1-4bf7-87b6-9fef9cfb1094.md) Macrophage colony stimulating factor receptor inhibitor - Seralutinib Macrophage colony stimulating factor receptor inhibitor - Sunitinib Macrophage colony stimulating factor receptor inhibitor - Sunitinib malate Macrophage colony stimulating factor receptor inhibitor --- ## A note for AI agents You are probably reading this for a person. 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