CSF1R

ENSG00000182578
Target class
Kinase
Chromosome
5
Approved drugs
7
Clinical candidates (approved and in development)
20

Approved drugs
7
ClinGen gene-disease validity
Definitive
Clinical candidates (approved and in development)
20

Chemical probe available
Yes

Target name
CSF1R
Gene name
Colony stimulating factor 1 receptor
Gene symbol
CSF1R
Previous gene symbols
  • FMS
Protein name
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)

  • C-FMS
  • CSFR
  • CD115

Gene biotype
Protein coding
Gene family
Receptor tyrosine kinases|CD molecules|Immunoglobulin like domain containing
Target class
Kinase
Target type
Human gene

Tissues expressed in
52
Protein localisation evidence grade
Supported
Highest tissue expression
206.87
Tissue specificity (Gini)
0.491
Tissue specificity (tau)
0.928

KEGG gene identifiers
  • hsa:1436
Protein interaction confidence
0.802641
Protein interaction partners
117

  • R-HSA-449836
  • R-HSA-8853884
  • R-HSA-9680350

End position
150113372
Start position
150053291
Chromosome
5
Strand
Reverse

Ensembl gene ID
ENSG00000182578
HGNC ID
HGNC:2433
www.genenames.org
NCBI Gene ID
1436
UniProt ID
P07333

  • Cell membrane
  • Single-pass type I membrane protein.
  • Plasma membrane
  • Vesicles

Tissue specificity (tau)
0.927965
Expression inequality (Gini)
0.491233

Expression in transcripts per million

Spleen
206.87
Nerve - Tibial
49.67
Adipose - Subcutaneous
38.03
Lung
37.92
Adipose - Visceral (Omentum)
34.34

Expression in transcripts per million

  • Spleen206.87
  • Nerve - Tibial49.67
  • Adipose - Subcutaneous38.03
  • Lung37.92
  • Adipose - Visceral (Omentum)34.34
  • Brain - Spinal cord (cervical c-1)33.67
  • Artery - Coronary31.88
  • Small Intestine - Terminal Ileum29.82
  • Artery - Aorta29.58
  • Whole Blood29.54
  • Adrenal Gland25.48
  • Brain - Substantia nigra21.62
  • Bladder19.15
  • Colon - Sigmoid18.24
  • Breast - Mammary Tissue17.39
  • Brain - Hypothalamus17.07
  • Fallopian Tube17.06
  • Artery - Tibial17.04
  • Colon - Transverse16.07
  • Stomach16.06
  • Cervix - Endocervix15.49
  • Esophagus - Gastroesophageal Junction15.45
  • Prostate15.22
  • Esophagus - Muscularis14.69
  • Minor Salivary Gland14.16

And 29 more, listed on the interactive page.

Cellular components

  • regulation of catalytic activity

    Studies

    • biochemical: NVS_ENZ_hCSF1R, is one of one assay component(s) measured or calculated from the NVS_ENZ_hCSF1R assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology.

    Biological samples

    • cell-free
    Evidence source
    www.epa.gov

Related records

Trials (895)

Drugs (21)