> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/crbn-169cf6df-ae17-5b19-8d78-a31c5759df96 > Record changed: 2026-10-13 # CRBN ENSG00000113851 Target class Unclassified protein Chromosome 3 Approved drugs 4 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 4 **ClinGen gene-disease validity** Moderate **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** Yes ## Names **Other names** - MRT2 **Target name** CRBN **Gene name** Cereblon **Gene symbol** CRBN **Previous gene symbols** - MRT2A **Protein name** Protein cereblon ## Classification **Gene biotype** Protein coding **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 40.85 **Tissue specificity (Gini)** 0.204 **Tissue specificity (tau)** 0.416 ## Pathways and interactions **KEGG gene identifiers** - hsa:51185 **Reactome pathways** - R-HSA-9679191 **Protein interaction confidence** 0.883717 **Protein interaction partners** 60 ## Genomic location **End position** 3179727 **Start position** 3144628 **Chromosome** 3 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000113851 **HGNC ID** HGNC:30185 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:30185) **NCBI Gene ID** 51185 **UniProt ID** Q96SW2 ## Cellular location - Cytoplasm . Nucleus . Membrane - Peripheral membrane protein . ### Publication evidence - PubMed 20223979 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20223979/) ## Tissue expression **Tissue specificity (tau)** 0.415944 **Expression inequality (Gini)** 0.203697 ### Highest expression Expression in transcripts per million **Nerve - Tibial** 40.85 **Testis** 39.61 **Artery - Tibial** 39 **Ovary** 38.12 **Brain - Cerebellar Hemisphere** 37.42 ### All tissues (54) Expression in transcripts per million - Nerve - Tibial40.85 - Testis39.61 - Artery - Tibial39 - Ovary38.12 - Brain - Cerebellar Hemisphere37.42 - Uterus36.63 - Cervix - Ectocervix36.5 - Brain - Spinal cord (cervical c-1)34.38 - Cervix - Endocervix33.82 - Adipose - Subcutaneous33.24 - Fallopian Tube32.75 - Bladder30.8 - Thyroid30.56 - Brain - Cerebellum30.52 - Artery - Coronary30.33 - Colon - Sigmoid30.14 - Breast - Mammary Tissue30.04 - Brain - Frontal Cortex (BA9)28.86 - Artery - Aorta28.52 - Esophagus - Gastroesophageal Junction28.39 - Esophagus - Muscularis27.64 - Lung27.63 - Spleen27.22 - Vagina25.26 - Prostate24.9 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0016567 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016567) - GO:0030177 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030177) - GO:0043161 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043161) ### Cellular components (4) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0031464 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031464) ### Molecular functions - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (1,854) - "Monoclonal Antibodies for Treatment of Multiple Myeloma. Emphasis on the CD38 Antibody Daratumumab " - \[Effects of Selected Statins on Cardiovascular Parameters in Healthy Volunteers\] - 1454GCC: Anti-PD-1 (MK-3475) and IMiD (Pomalidomide) Combination Immunotherapy in Relapsed/Refractory Multiple Myeloma - 2015-09: a Phase II Randomized, Open-label Study of Anti-signaling Lymphocytic Activation Molecule Monoclonal Antibody During Maintenance Therapy - 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy - 2017-03: A Single-Arm, Open-label Study of Anti-Signaling Lymphocytic Activation Molecule F7 (Anti-SLAMF7) Monoclonal Antibody (mAb) Therapy After Autologous Stem Cell Transplant in Patients With Multiple Myeloma - 5 mg Glipizide/500 mg Metformin Hydrochloride Tablets, Fasting - 5 mg Glipizide/500 mg Metformin Hydrochloride Tablets, Non-Fasting - 5-Azacytidine With Lenalidomide in Patients With High Risk Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML) - A 2 Stage Trial of Lenalidomide (REV) in Asymptomatic Ovarian Cancer Patients With Increasing CA 125 in Late Relapse - A Bioequivalence Study Comparing A Fixed Dose Combination Formulation Of Myrin P Forte That Contains Rifampicin, Isoniazid, Ethambutol And Pyrazinamide Per Tablet To An Equivalent Dose Of Single Drug Reference Preparations Of Similar Combination Following Oral Administration In Healthy Adults - A Clinical Study Comparing SG301 Plus Pomalidomide and Dexamethasone to Placebo Plus Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma Patients - A Clinical Study of Injectable IMM0306 in Combination With Lenalidomide - A Clinical Study to Test the Effects of Ruxolitinib And Thalidomide Combination for Patients With Myelofibrosis - A Clinical Trial of PGDM1400 and PGT121 and VRC07-523LS Monoclonal Antibodies in HIV-infected and HIV-uninfected Adults - A Clinical Trial to Evaluate the Efficacy and Safety of TQB3909 Tablets Versus Investigator's Choice in the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) - A Companion Study for Studies THAL-MM-003, CC-5013-MM-009, and CC-5013-MM-010 for Subjects With Multiple Myeloma - A Dose Escalation Study of Carfilzomib Taken With Thalidomide and Dexamethasone in Relapsed AL Amyloidosis - A Dose Escalation Study of Lenalidomide in Relapsed or Refractory B-cell Chronic Lymphocytic Leukemia - A Dose Escalation Study of the Combination of Lenalidomide (Revlimid®), Dexamethasone and Cyclophosphamide in Patients Refractory or Relapsing From Stable Disease With Multiple Myeloma ### Drugs (5) - Iberdomide CRL4(CRBN) E3 ubiquitin ligase modulator - [Lenalidomide](https://trialight.com/data/asset/lenalidomide-1e614dfb-efd0-4006-a121-30a97656c7a9.md) CRL4(CRBN) E3 ubiquitin ligase inhibitor; CRL4(CRBN) E3 ubiquitin ligase modulator - Lenalidomide hydrochloride monohydrate CRL4(CRBN) E3 ubiquitin ligase modulator - [Pomalidomide](https://trialight.com/data/asset/pomalidomide-8cab22f9-2d15-4e50-9ef9-334f56340121.md) CRL4(CRBN) E3 ubiquitin ligase inhibitor - Thalidomide CRL4(CRBN) E3 ubiquitin ligase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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