> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/cnr2-ac6f2c83-403e-56ec-b4e0-166a65ef5bad
> Record changed: 2026-11-04

# CNR2

ENSG00000188822

Target class

GPCR

Chromosome

1

Approved drugs

0

Clinical candidates (approved and in development)

8

## Clinical evidence

**Approved drugs**

0

**Clinical candidates (approved and in development)**

8

## Druggability

**Chemical probe available**

Yes

## Names

**Other names**

- CB2

**Target name**

CNR2

**Gene name**

Cannabinoid receptor 2

**Gene symbol**

CNR2

**Protein name**

Cannabinoid receptor 2 (CB-2) (CB2) (hCB2) (CX5)

## Classification

**Gene biotype**

Protein coding

**Gene family**

Cannabinoid receptors

**Target class**

GPCR

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

4

**Highest tissue expression**

16.58

**Tissue specificity (Gini)**

0.937

**Tissue specificity (tau)**

0.98

## Pathways and interactions

**KEGG gene identifiers**

- hsa:1269

**Protein interaction confidence**

0.8564

**Protein interaction partners**

10

### Reactome pathways (2)

- R-HSA-373076
- R-HSA-418594

## Genomic location

**End position**

23913362

**Start position**

23870515

**Chromosome**

1

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000188822

**HGNC ID**

HGNC:2160

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2160)

**NCBI Gene ID**

1269

**UniProt ID**

P34972

## Cellular location

- Cell membrane
- Multi-pass membrane protein. Cell projection, dendrite . Perikaryon . Note=Localizes to apical dendrite of pyramidal neurons. .

## Tissue expression

**Tissue specificity (tau)**

0.980153

**Expression inequality (Gini)**

0.936878

### Highest expression

Expression in transcripts per million

**Spleen**

16.58

**Cells - EBV-transformed lymphocytes**

12.43

**Small Intestine - Terminal Ileum**

2.08

**Whole Blood**

1.24

**Thyroid**

0.38

### All tissues (54)

Expression in transcripts per million

- Spleen16.58
- Cells - EBV-transformed lymphocytes12.43
- Small Intestine - Terminal Ileum2.08
- Whole Blood1.24
- Thyroid0.38
- Testis0.26
- Lung0.15
- Colon - Transverse0.09
- Esophagus - Mucosa0.07
- Liver0.06
- Prostate0.04
- Fallopian Tube0.04
- Adipose - Visceral (Omentum)0.04
- Kidney - Medulla0.03
- Cervix - Endocervix0.03
- Stomach0.03
- Cervix - Ectocervix0.03
- Kidney - Cortex0.03
- Artery - Coronary0.03
- Bladder0.03
- Artery - Aorta0.03
- Adipose - Subcutaneous0.02
- Vagina0.02
- Pituitary0.02
- Minor Salivary Gland0.02

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (2)

- GO:0038171  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038171)
- GO:0045669  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045669)

### Cellular components (2)

- GO:0005783  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)

### Molecular functions (2)

- GO:0004949  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004949)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)

## On-target safety

- decreased inflammation  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased inflammation  
### Biological samples (2)

  - nervous system
  - Immune  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased inflammation  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased inflammation  
### Biological samples (2)

  - nervous system
  - Immune  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased pain  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased pain  
### Biological samples (2)

  - nervous system
  - Immune  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

## Off-target safety

- increased inflammation  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: increased inflammation  
### Biological samples

  - Immune  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- decreased bone mass  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: decreased bone mass  
### Biological samples

  - Immune  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)

## Related records

### Trials (270)

- A Laboratory Model of Increasing Delta-9-tetrahydrocannabinol (THC) Potency on Cigarette Smoking
- A Multicenter Study to Evaluate the Efficacy and Safety of of Four Doses of SR147778 in Obese Patients
- A Phase I/II Study to Evaluate Single Agent and Combination Therapy With Megestrol Acetate and Dronabinol for the Treatment of HIV-Wasting Syndrome
- A Phase Ib/IIa, Double-Blind, Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of S-777469 in Subjects With Atopic Dermatitis
- A Phase IV Trial of Cesamet™ Given With Standard Antiemetic Therapy for Chemotherapy-induced Nausea and Vomiting
- A Pilot Study of Dronabinol for Adult Patients With Primary Gliomas
- A Pilot Trial of Nabilone for the Treatment of Obesity
- A Placebo-Controlled Study of MK0634 in Patients With Overactive Bladder (0634-007)
- A Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of 2 Doses of S-777469 in Patients With Atopic Dermatitis
- A RCT Comparing Dronabinol to a Placebo for Post-operative Pain in Total Joint Arthroplasty
- A Study of Cybis™ 10:25 THC:CBD Oil in Adults With Chronic Back/Neck Pain
- A Study of GW842166 in Adults With Osteoarthritis Pain
- A Study of LY2828360 in Patients With Osteoarthritic Knee Pain
- A Study of MK0364 in Obese Patients (0364-014)
- A Study Of Synthetic THC And Sleep
- A Study of the Abuse Potential of Dronabinol in Recreational Cannabinoid Users
- A Study Of The Effects Of CB2 Compound Of GW842166 In Patients With Osteoarthritis
- A Study Testing the Safety and Effects of Single Doses of S1-221 in Healthy Volunteers
- A Study to Investigate a Research Drug as an Aid for Smoking Cessation in Chronic Cigarette Smokers (0364-007)
- A Study to Investigate the Efficacy and Safety of RG7774 in Patients With Diabetes Mellitus Type 1 or Type 2 With Treatment-Naive Diabetic Retinopathy

### Drugs (17)

- Beta-caryophyllene
- [Dronabinol](https://trialight.com/data/asset/dronabinol-b3414807-1cde-4111-8024-a7a366127956.md)
- GW842166X Cannabinoid CB2 receptor agonist
- Ibipinabant
- Lenabasum
- LY2828360 Cannabinoid CB2 receptor agonist
- Nabilone
- Nonabine Cannabinoid CB2 receptor agonist
- Olorinab Cannabinoid CB2 receptor agonist
- Onternabez
- PRS-211375 Cannabinoid CB2 receptor agonist
- S-777469 Cannabinoid CB2 receptor agonist
- SAD448 Cannabinoid CB2 receptor agonist
- Surinabant
- Taranabant
- Tedalinab Cannabinoid CB2 receptor agonist
- Vicasinabin

---

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