> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/cnr1-48d3113c-29b0-54a7-95e5-e98fe846a8e6
> Record changed: 2026-10-13

# CNR1

ENSG00000118432

Target class

GPCR

Chromosome

6

Approved drugs

4

Clinical candidates (approved and in development)

13

## Clinical evidence

**Approved drugs**

4

**Clinical candidates (approved and in development)**

13

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

CNR1

**Gene name**

Cannabinoid receptor 1

**Gene symbol**

CNR1

**Previous gene symbols**

- CNR

**Protein name**

Cannabinoid receptor 1 (CB-R) (CB1) (CANN6)

### Other names (5)

- CB1K5
- CB-R
- CB1
- CANN6
- CB1A

## Classification

**Gene biotype**

Protein coding

**Gene family**

Cannabinoid receptors

**Target class**

GPCR

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

47

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

33.9

**Tissue specificity (Gini)**

0.516

**Tissue specificity (tau)**

0.738

## Pathways and interactions

**KEGG gene identifiers**

- hsa:1268

**Protein interaction confidence**

0.854975

**Protein interaction partners**

40

### Reactome pathways (2)

- R-HSA-373076
- R-HSA-418594

## Genomic location

**End position**

88167364

**Start position**

88139863

**Chromosome**

6

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000118432

**HGNC ID**

HGNC:2159

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2159)

**NCBI Gene ID**

1268

**UniProt ID**

P21554

## Cellular location

- Cell membrane
- Multi-pass membrane protein . Membrane raft . Mitochondrion outer membrane . Cell projection, axon . Presynapse . Note=Unexpectedly, in the mitochondria, the C-terminus is located in the mitochondrial intermembrane space, a compartment topologically considered as extracellular. In canonical seven-transmembrane G-protein coupled receptors, the C-terminus is cytosolic (By similarity). Found on presynaptic axon terminals in some GABAergic neurons in the somatosensory cortex (By similarity). .
- Plasma membrane

### Publication evidence (3)

- PubMed 21895628  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21895628/)
- PubMed 27768894  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27768894/)
- PubMed 27851727  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27851727/)

## Tissue expression

**Tissue specificity (tau)**

0.737563

**Expression inequality (Gini)**

0.516383

### Highest expression

Expression in transcripts per million

**Brain - Cerebellar Hemisphere**

33.9

**Brain - Cerebellum**

29.4

**Pituitary**

29.33

**Cells - Cultured fibroblasts**

26.92

**Adipose - Subcutaneous**

26.04

### All tissues (54)

Expression in transcripts per million

- Brain - Cerebellar Hemisphere33.9
- Brain - Cerebellum29.4
- Pituitary29.33
- Cells - Cultured fibroblasts26.92
- Adipose - Subcutaneous26.04
- Adipose - Visceral (Omentum)26.04
- Fallopian Tube25.23
- Artery - Tibial23.72
- Breast - Mammary Tissue18.99
- Brain - Anterior cingulate cortex (BA24)18.79
- Colon - Sigmoid17.51
- Brain - Frontal Cortex (BA9)16.89
- Small Intestine - Terminal Ileum13.88
- Brain - Cortex13.09
- Brain - Caudate (basal ganglia)12.87
- Brain - Putamen (basal ganglia)11.97
- Brain - Hippocampus10.92
- Brain - Amygdala9.36
- Esophagus - Gastroesophageal Junction9.31
- Nerve - Tibial9.31
- Brain - Hypothalamus9.15
- Colon - Transverse8.72
- Esophagus - Muscularis7.63
- Brain - Nucleus accumbens (basal ganglia)7.46
- Uterus7.38

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (3)

- GO:0007187  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007187)
- GO:0007188  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007188)
- GO:0038171  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038171)

### Cellular components (2)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0045121  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045121)

### Molecular functions (3)

- GO:0004949  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004949)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0042802  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802)

## On-target safety

- catalepsy  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: catalepsy  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- headache  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: headache  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- hallucinations  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: hallucinations  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased pain  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased pain  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- nervousness  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: nervousness  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased heart rate  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased heart rate  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased body temperature  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased body temperature  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- dysphoria  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: dysphoria  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- drowsiness  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: drowsiness  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased eating  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased eating  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- dizziness  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: dizziness  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased locomotor activity  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased locomotor activity  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased convulsions  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased convulsions  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- drug abuse/dependence  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: drug abuse/dependence  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased convulsions  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased convulsions  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased blood pressure  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased blood pressure  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased eating  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased eating  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

## Off-target safety

- dysphoria  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: dysphoria  
### Biological samples

  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- anxiety  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: anxiety  
### Biological samples

  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- poor concentration  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: poor concentration  
### Biological samples

  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- depression  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: depression  
### Biological samples

  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- memory impairment  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: memory impairment  
### Biological samples

  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- euphoria  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: euphoria  
### Biological samples

  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- increased weight loss  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: increased weight loss  
### Biological samples

  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- hypothermia  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: hypothermia  
### Biological samples

  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- emesis  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: emesis  
### Biological samples

  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- analgesia  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: analgesia  
### Biological samples

  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)

## Related records

### Trials (871)

- A 1-Year Study On The Effects Of CP-945,598 For The Treatment Of Obesity In Overweight Type 2 Diabetic Patients
- A 14-Month Study On The Effects Of CP-945,598 For The Prevention Of Weight Regain In Obese Patients
- A Clinical Study to Compare BupiZenge With Lidocaine for Pain Due to Oral Mucositis in Patients With Head and Neck Cancer.
- A Clinical Trial of a Hemp-Derived Cannabidiol Product for Anxiety
- A Clinical Trial of a Hemp-Derived, High Cannabidiol Product for Anxiety in Glioblastoma Patients
- A Clinical Trial on the Antipsychotic Properties of Cannabidiol
- A Dose-ranging Pharmacokinetics and Safety Study of GWP42003-P in Children With Dravet Syndrome (GWPCARE1)
- A Double-Blind Trial to Evaluate Efficacy and Safety of Cannabidiol as an add-on Therapy for Treatment in Refractory Epilepsy
- A Four-week Clinical Trial Investigating Efficacy and Safety of Cannabidiol As a Treatment for Acutely Ill Schizophrenic Patients
- A Glycemic Control Evaluation of Glimepiride Versus Rimonabant on Top of Metformin in Type 2 Diabetes
- A Laboratory Model of Increasing Delta-9-tetrahydrocannabinol (THC) Potency on Cigarette Smoking
- A Long-term Safety Study of Cannabidiol Oral Solution (GWP42003-P, CBD-OS) in Patients With Rett Syndrome
- A Long-Term Study To Examine The Effects Of CP-945,598 On Weight Loss And Safety
- A Medical Cannabis Oil for Treatment of Agitation and Disruptive Behaviors in Subjects With Dementia.
- A Multicenter Study to Evaluate the Efficacy and Safety of of Four Doses of SR147778 in Obese Patients
- A Pharmacodynamics, Pharmacokinetics, and Safety Study of Hydrochlorothiazide and Canagliflozin in Healthy Volunteers
- A Pharmacokinetic Study to Compare CBD-NE to Epidyolex in Healthy Adult Volunteers Under Both Fed and Fasted Conditions
- A Phase 1, Randomized Pharmacokinetics and Safety Study of Extended Duration Dapivirine Vaginal Rings
- A Phase 2a Study to Evaluate the Safety and Efficacy of Cannabidiol Only as Maintenance Therapy and Steroid Sparing in Patients With Stable Autoimmune Hepatitis
- A Phase 2a Study to Evaluate the Safety, Tolerability and Efficacy of Cannabidiol as a Steroid-sparing Therapy in Steroid-dependent Crohn's Disease Patients

### Drugs (13)

- AZD2207 Cannabinoid CB1 receptor antagonist
- Cannabidiol Cannabinoid CB1 receptor negative allosteric modulator
- Drinabant Cannabinoid CB1 receptor antagonist
- [Dronabinol](https://trialight.com/data/asset/dronabinol-b3414807-1cde-4111-8024-a7a366127956.md) Cannabinoid CB1 receptor agonist
- Ibipinabant Cannabinoid CB1 receptor antagonist
- Nabilone Cannabinoid CB1 receptor agonist
- Nimacimab Cannabinoid CB1 receptor negative allosteric modulator
- Nonabine Cannabinoid CB1 receptor agonist
- Otenabant Cannabinoid CB1 receptor antagonist
- Rimonabant Cannabinoid CB1 receptor antagonist
- SAD448 Cannabinoid CB1 receptor agonist
- Surinabant Cannabinoid CB1 receptor antagonist
- Taranabant Cannabinoid CB1 receptor inverse agonist

---

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