> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/clec4c-3a0e0bbf-e22d-5b05-8801-ee683a6db606 > Record changed: 2026-10-13 # CLEC4C ENSG00000198178 Target class Membrane receptor Chromosome 12 Approved drugs 0 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** No ## Names **Target name** CLEC4C **Gene name** C-type lectin domain family 4 member C **Gene symbol** CLEC4C **Protein name** C-type lectin domain family 4 member C (Blood dendritic cell antigen 2) (BDCA-2) (C-type lectin superfamily member 7) (Dendritic lectin) (CD antigen CD303) ### Other names (4) - HECL - DLEC - BDCA2 - CD303 ### Previous gene symbols (2) - CLECSF11 - CLECSF7 ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|C-type lectin domain containing **Target class** Membrane receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 1 **Highest tissue expression** 1.13 **Tissue specificity (Gini)** 0.949 **Tissue specificity (tau)** 0.983 ## Pathways and interactions **KEGG gene identifiers** - hsa:170482 **Protein interaction confidence** 0.8492 **Protein interaction partners** 10 ### Reactome pathways (2) - R-HSA-5621480 - R-HSA-6798695 ## Genomic location **End position** 7751620 **Start position** 7724646 **Chromosome** 12 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000198178 **HGNC ID** HGNC:13258 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:13258) **NCBI Gene ID** 170482 **UniProt ID** Q8WTT0 ## Cellular location - Cell membrane - Single-pass type II membrane protein . ### Publication evidence (2) - PubMed 11748283 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11748283/) - PubMed 21880719 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21880719/) ## Tissue expression **Tissue specificity (tau)** 0.982802 **Expression inequality (Gini)** 0.949074 ### Highest expression Expression in transcripts per million **Testis** 1.13 **Whole Blood** 0.52 **Cells - EBV-transformed lymphocytes** 0.27 **Spleen** 0.17 **Lung** 0.04 ### All tissues (54) Expression in transcripts per million - Testis1.13 - Whole Blood0.52 - Cells - EBV-transformed lymphocytes0.27 - Spleen0.17 - Lung0.04 - Bladder0.02 - Kidney - Medulla0.01 - Fallopian Tube0 - Brain - Cerebellum0 - Breast - Mammary Tissue0 - Esophagus - Gastroesophageal Junction0 - Uterus0 - Heart - Left Ventricle0 - Brain - Hippocampus0 - Pituitary0 - Nerve - Tibial0 - Prostate0 - Thyroid0 - Brain - Cortex0 - Brain - Anterior cingulate cortex (BA24)0 - Esophagus - Mucosa0 - Muscle - Skeletal0 - Artery - Coronary0 - Kidney - Cortex0 - Adipose - Visceral (Omentum)0 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components (4) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0030667 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030667) - GO:0070821 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070821) - GO:0101003 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0101003) ### Molecular functions - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (9) - A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus - A Long-Term Extension Study to Learn More About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus - [A Study to Find Out How Litifilimab is Processed in the Body in Healthy Participants When Given Under the Skin in 3 Different Ways](https://trialight.com/data/trial/a-study-to-find-out-how-litifilimab-is-processed-in-the-body-8cf31b4c-cb0c-4bdc-af2c-a813de5b2e3e.md) - A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus - A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus - An Extension Study to Learn More About the Long-Term Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus - Safety, Tolerability, and Pharmacokinetics of Single Doses of BIIB059 in Healthy Japanese Subjects. - Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Single Doses and Multiple Doses of BIIB059 (Litifilimab) in Healthy Volunteers and Participants With Systemic Lupus Erythematosus - Study to Evaluate BIIB059 (Litifilimab) in Cutaneous Lupus Erythematosus (CLE) With or Without Systemic Lupus Erythematosus (SLE) ### Drugs (1) - [Litifilimab](https://trialight.com/data/asset/litifilimab-7b0edbb2-543a-4a80-9535-9455f1432e2a.md) C-type lectin domain family 4 member C inhibitor --- ## A note for AI agents You are probably reading this for a person. 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