> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cldn18-4ae331d7-34cb-5cdf-89a7-d784780b2278 > Record changed: 2026-10-13 # CLDN18 ENSG00000066405 Target class Unclassified protein Chromosome 3 Approved drugs 1 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** No ## Names **Target name** CLDN18 **Gene name** Claudin 18 **Gene symbol** CLDN18 **Previous gene symbols** - SFTPJ **Protein name** Claudin-18 ## Classification **Gene biotype** Protein coding **Gene family** Claudins **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 6 **Protein localisation evidence grade** Approved **Highest tissue expression** 391.23 **Tissue specificity (Gini)** 0.949 **Tissue specificity (tau)** 0.992 ## Pathways and interactions **KEGG gene identifiers** - hsa:51208 **Reactome pathways** - R-HSA-420029 **Protein interaction confidence** 0.756474 **Protein interaction partners** 19 ## Genomic location **End position** 138033655 **Start position** 137998735 **Chromosome** 3 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000066405 **HGNC ID** HGNC:2039 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2039) **NCBI Gene ID** 51208 **UniProt ID** P56856 ## Cellular location - Cell junction, tight junction . Cell membrane - Multi-pass membrane protein . Note=Localizes to tight junctions in epithelial cells. . - SUBCELLULAR LOCATION: \[Isoform A1\]: Cell junction, tight junction . - SUBCELLULAR LOCATION: \[Isoform A2\]: Cell junction, tight junction . Lateral cell membrane . - Cell Junctions ## Tissue expression **Tissue specificity (tau)** 0.992146 **Expression inequality (Gini)** 0.948958 ### Highest expression Expression in transcripts per million **Stomach** 391.23 **Lung** 140.5 **Testis** 2.3 **Ovary** 1.06 **Uterus** 1.05 ### All tissues (54) Expression in transcripts per million - Stomach391.23 - Lung140.5 - Testis2.3 - Ovary1.06 - Uterus1.05 - Cervix - Ectocervix1.04 - Fallopian Tube0.98 - Cervix - Endocervix0.96 - Artery - Aorta0.83 - Pituitary0.75 - Bladder0.7 - Brain - Cerebellum0.68 - Nerve - Tibial0.68 - Vagina0.66 - Artery - Tibial0.63 - Artery - Coronary0.62 - Cells - Cultured fibroblasts0.54 - Esophagus - Gastroesophageal Junction0.53 - Prostate0.52 - Heart - Atrial Appendage0.52 - Colon - Sigmoid0.48 - Esophagus - Muscularis0.47 - Thyroid0.46 - Brain - Cerebellar Hemisphere0.45 - Kidney - Medulla0.42 And 29 more, listed on the interactive page. ## Biological functions ### Molecular functions - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (22) - A Pharmacokinetic Study of Zolbetuximab (IMAB362) in Chinese Subjects With Locally Advanced Unresectable or Metastatic Gastric or Gastro-esophageal Junction (GEJ) Adenocarcinoma - A Phase Ib/II Trial of Neoadjuvant Zolbetuximab Plus Docetaxel, Oxaliplatin and S-1 Chemotherapy in Patients With Locally Advanced Gastric Cancer - A Study of IMAB362 in Japanese Subjects With Locally Advanced or Metastatic Gastric or Gastro-esophageal Junction (GEJ) Adenocarcinoma - A Study of Zolbetuximab (IMAB362) in Adults With Gastric Cancer - A Study of Zolbetuximab (IMAB362) in Adults With Pancreatic Cancer - A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-positive, HER2-negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (GLOW). - A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer - A Study of Zolbetuximab With Chemotherapy in Adults With Pancreatic Cancer - A Study to Compare Zolbetuximab (IMAB362) and Chemotherapy With Placebo and Chemotherapy in Adults With Gastric Cancer. - A Study to Observe the Safety of VYLOY (Zolbetuximab) in People in South Korea With Gastric or Gastroesophageal Junction Cancer. - AACR Adaptive Biomarker-Driven Organ Preservation Trial in Gastroesophageal Adenocarcinomas - Early Access Program for Zolbetuximab - Efficacy and Safety of IMAB362 in Combination With the EOX Regimen for CLDN18.2-positive Gastric Cancer - Efficacy and Safety Study of Multiple Doses of IMAB362 in Patients With Advanced Gastroesophageal Cancer - Establishment of Precision Targeted Therapy Strategies for Advanced Gastric Cancer Based on Novel Molecular Subtyping - Phase Ib/IIa Open-label Study, to Evaluate Safety, Tolerability, and Antitumor Activity of HCB101 in Combination With Multiple Agents in Subjects With Advanced Gastric or Gastro-esophageal (GEJ) Adenocarcinoma - Phase II RAINSPOT: Zolbetuximab-Paclitaxel-Ramucirumab for CLDN18.2 Positive Gastro-esophageal Cancer - Safety and Activity of IMAB362 in Combination With Zoledronic Acid and Interleukin-2 in CLDN18.2-positive Gastric Cancer - Safety and Tolerability Study of Claudiximab in Patients With Advanced Gastroesophageal Cancer - [Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2](https://trialight.com/data/trial/sonesitatug-vedotin-in-combination-with-capecitabine-with-or-6e8d2b04-9d03-48ef-b51d-43f330fdaeed.md) ### Drugs (1) - [Zolbetuximab](https://trialight.com/data/asset/zolbetuximab-93fd9fa2-039b-41eb-a488-43bca0e39a5b.md) Claudin-18 binding agent --- ## A note for AI agents You are probably reading this for a person. 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