> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/clcn2-fbaa8ed8-a07f-5031-a5ab-aade5a87eb87 > Record changed: 2026-11-04 # CLCN2 ENSG00000114859 Target class Ion channel Chromosome 3 Approved drugs 1 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Refuted **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** Yes ## Names **Target name** CLCN2 **Gene name** Chloride voltage-gated channel 2 **Gene symbol** CLCN2 **Protein name** Chloride channel protein 2 (ClC-2) ### Other names (3) - CLC2 - EJM6 - ClC-2 ## Classification **Gene biotype** Protein coding **Gene family** CLC chloride channel and transporter family **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 51 **Protein localisation evidence grade** Approved **Highest tissue expression** 26.78 **Tissue specificity (Gini)** 0.424 **Tissue specificity (tau)** 0.819 ## Pathways and interactions **KEGG gene identifiers** - hsa:1181 **Reactome pathways** - R-HSA-2672351 **Protein interaction confidence** 0.820444 **Protein interaction partners** 9 ## Genomic location **End position** 184363274 **Start position** 184346185 **Chromosome** 3 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000114859 **HGNC ID** HGNC:2020 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:2020) **NCBI Gene ID** 1181 **UniProt ID** P51788 ## Cellular location - Cell membrane - Multi-pass membrane protein . Basolateral cell membrane - Multi-pass membrane protein . Cell projection, dendritic spine membrane - Multi-pass membrane protein . Cell projection, axon . Note=Sorting to the basolateral membrane is mediated by AP-1 clathrin adapter (PubMed:16155254). Localizes at axon initial segments and dendritic shaft and spikes. Colocalizes with HEPACAM and GFAP at astrocyte end-foot in contact with brain capillaries and other glial cells (By similarity) (PubMed:22405205, PubMed:23707145). . - Cytosol ### Publication evidence (6) - PubMed 22405205 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22405205/) - PubMed 23707145 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23707145/) - PubMed 29403011 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/29403011/) - PubMed 36964785 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36964785/) - PubMed 38345841 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38345841/) - PubMed 16155254 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16155254/) ## Tissue expression **Tissue specificity (tau)** 0.81912 **Expression inequality (Gini)** 0.424277 ### Highest expression Expression in transcripts per million **Nerve - Tibial** 26.78 **Testis** 25.51 **Brain - Cerebellum** 16.25 **Brain - Cerebellar Hemisphere** 14.21 **Ovary** 11.56 ### All tissues (54) Expression in transcripts per million - Nerve - Tibial26.78 - Testis25.51 - Brain - Cerebellum16.25 - Brain - Cerebellar Hemisphere14.21 - Ovary11.56 - Uterus10.4 - Cervix - Endocervix8.39 - Colon - Transverse8.38 - Small Intestine - Terminal Ileum7.35 - Pituitary7.01 - Cervix - Ectocervix6.84 - Brain - Spinal cord (cervical c-1)6.78 - Fallopian Tube6.56 - Adrenal Gland6.36 - Thyroid6.36 - Artery - Aorta5 - Prostate4.71 - Kidney - Medulla4.48 - Vagina4.44 - Bladder4.26 - Colon - Sigmoid4.25 - Brain - Cortex4.11 - Artery - Coronary4.05 - Artery - Tibial3.86 - Esophagus - Gastroesophageal Junction3.67 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0006911 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006911) - GO:0032347 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032347) ### Cellular components (4) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016323 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016323) - GO:0043209 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043209) - GO:0097450 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097450) ### Molecular functions (2) - GO:0005247 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005247) - GO:0017081 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017081) ## Related records ### Trials (428) - "Pharmacodynamic Comparison of Omeprazole Versus Pantoprazole on Platelet Reactivity in Patients With Acute Coronary Syndromes on Dual Antiplatelet Therapy With New P2Y12 Inhibitors" -Trial dOPPLER- - 13-C Urea Breath Test Using BreathID System and PPIs (Proton Pump Inhibitors) - A 5-Period, Single Dose, Phase 1 Study in Healthy Elderly Subjects to Assess Relative Bioavailability and Food Effect of Two Oral Formulations of GSK1325756 (Free Base vs HBr Salt) and Food Effect on the HBr Formulation When Given With Omeprazole - A Clinical Trial to Evaluate a High-Fat Meal and Omeprazole Enteric-coated Tablets on ASBK021 - A Clinical Trial to Evaluate JAB-21822 Drug-drug Interactions in Healthy Subjects - [A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)](https://trialight.com/data/trial/a-clinical-trial-to-evaluate-mk-4208-embibatinib-in-healthy-7e3461de-b189-4af2-af82-5175294701bc.md) - A Drug Interaction Study of the Effects of PPI-668 on the Pharmacokinetics of Midazolam and Omeprazole - A Drug Interaction Study to Assess the Effect of Omeprazole on the Pharmacokinetics of Ibrutinib in Healthy Adults - A Drug-drug Interaction Study of Famitinib Malate With a Proton Pump Inhibitor in Healthy Adult Subjects - A Multi-center, Randomized, Double-blind Phase III Clinical Trial to Assess and Compare to the Efficacy and Safety of Lafutidine, Famotidine and Omeprazole-referenced in Korean Erosive Esophagitis Patients - A Multiple-Dose Pharmacokinetics Study of Three Gefapixant (AF-219/MK-7264) Formulations - A Multiple-Dose Pharmacokinetics Study of Two Gefapixant (AF-219/MK-7264) Formulations - A Parallel Group Study to Compare the Gastroprotective Effects of PA 325 Versus 81 mg Enteric Coated Aspirin - A Pharmacodynamic Study Comparing Zegerid® and Prilosec OTC® (CL2007-17 )(P07813)(COMPLETED) - A Pharmacodynamic Study Comparing Zegerid® and Prilosec OTC® (Study CL2008-02)(P07814)(COMPLETED) - A Phase 1 Study to Evaluate the Effects of Omeprazole and Famotidine on the Absorption of Telotristat Ethyl in Healthy Subjects - A Phase 1 Study to Examine the Pharmacodynamics of Different AZD1722 Formulations - A PHASE 1, OPEN-LABEL, CROSS-OVER, FIXED SEQUENCE STUDY TO EVALUATE THE EFFECT OF MULTIPLE DOSES OF DS-1971A ON THE SINGLE DOSE PHARMACOKINETICS OF PROBE SUBSTRATES FOR CYP2B6, CYP2C8, CYP2C9, CYP2C19 AND CYP3A4 ENZYMES IN HEALTHY MALE AND FEMALE SUBJECTS - A Phase 2 Clinical Trial of the Safety and Effects of IRX-2 in Treating Patients With Operable Head and Neck Cancer - A Phase I Study of the Interaction of D-2570 With Other Drugs in Healthy Adults ### Drugs (4) - Cobiprostone Chloride channel protein 2 activator - Fenamic acid - Lubiprostone Chloride channel protein 2 opener - [Omeprazole](https://trialight.com/data/asset/omeprazole-042440e1-a0fc-438d-a87b-7f2e8fa68dad.md) --- ## A note for AI agents You are probably reading this for a person. 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