> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/chrna7-8bdaaeab-5d82-502b-b193-bdcca12765df > Record changed: 2026-11-04 # CHRNA7 ENSG00000175344 Target class Ion channel Chromosome 15 Approved drugs 0 Clinical candidates (approved and in development) 17 ## Clinical evidence **Approved drugs** 0 **ClinGen gene-disease validity** Refuted **Clinical candidates (approved and in development)** 17 ## Druggability **Chemical probe available** No ## Names **Other names** - a7nAChR **Target name** CHRNA7 **Gene name** Cholinergic receptor nicotinic alpha 7 subunit **Gene symbol** CHRNA7 **Protein name** Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7) ## Classification **Gene biotype** Protein coding **Gene family** Cholinergic receptors nicotinic subunits **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 0 **Highest tissue expression** 0.77 **Tissue specificity (Gini)** 0.488 **Tissue specificity (tau)** 0.805 ## Pathways and interactions **KEGG gene identifiers** - hsa:1139 **Reactome pathways** - R-HSA-629594 **Protein interaction confidence** 0.853385 **Protein interaction partners** 13 ## Genomic location **End position** 32173018 **Start position** 31923438 **Chromosome** 15 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000175344 **HGNC ID** HGNC:1960 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1960) **NCBI Gene ID** 1139 **UniProt ID** P36544 ## Cellular location - Postsynaptic cell membrane - Multi-pass membrane protein . Cell membrane - Multi-pass membrane protein . Note=TMEM35A/NACHO promotes its trafficking to the cell membrane (PubMed:27789755). RIC3 promotes its trafficking to the cell membrane (By similarity). . ### Publication evidence - PubMed 27789755 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27789755/) ## Tissue expression **Tissue specificity (tau)** 0.80544 **Expression inequality (Gini)** 0.487583 ### Highest expression Expression in transcripts per million **Testis** 0.77 **Thyroid** 0.68 **Ovary** 0.59 **Stomach** 0.48 **Small Intestine - Terminal Ileum** 0.45 ### All tissues (54) Expression in transcripts per million - Testis0.77 - Thyroid0.68 - Ovary0.59 - Stomach0.48 - Small Intestine - Terminal Ileum0.45 - Brain - Frontal Cortex (BA9)0.39 - Brain - Cortex0.33 - Prostate0.28 - Artery - Aorta0.27 - Pancreas0.26 - Pituitary0.23 - Spleen0.23 - Brain - Anterior cingulate cortex (BA24)0.22 - Brain - Hypothalamus0.2 - Vagina0.19 - Uterus0.16 - Cervix - Ectocervix0.16 - Cervix - Endocervix0.15 - Colon - Transverse0.14 - Colon - Sigmoid0.14 - Brain - Amygdala0.13 - Nerve - Tibial0.12 - Lung0.12 - Esophagus - Muscularis0.12 - Esophagus - Gastroesophageal Junction0.11 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (20) - GO:0001666 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001666) - GO:0006816 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006816) - GO:0006874 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006874) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007268 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007268) - GO:0007271 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007271) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0032720 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032720) - GO:0034220 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034220) - GO:0035094 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035094) - GO:0043124 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043124) - GO:0043410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410) - GO:0045766 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045766) - GO:0050890 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050890) - GO:0060079 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060079) - GO:0095500 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0095500) - GO:1900016 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900016) - GO:1902430 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902430) - GO:1902991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902991) - GO:1905144 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905144) ### Cellular components (4) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005892 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005892) - GO:0045211 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045211) - GO:0098794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098794) ### Molecular functions (11) - GO:0001540 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001540) - GO:0004888 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004888) - GO:0005216 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005216) - GO:0005262 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005262) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015464 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015464) - GO:0015643 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015643) - GO:0017081 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017081) - GO:0022848 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0022848) - GO:0042166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042166) - GO:0042803 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803) ## Related records ### Trials (315) - A 26-Week Extension Study of EVP-6124 (Alpha-7 nAChR) as an Adjunctive Pro-Cognitive Treatment in Schizophrenia Subjects on Chronic Stable Atypical Antipsychotic Therapy - A Bioequivalence Study, Comparing Two Formulations of Ivermectin Lotion, 0.5% - A Clinical Endpoint Bioequivalence Study to Assess Efficacy and Safety of Ivermectin 0.5% Lotion in the Treatment of Head Lice - A Comparative Study on Ivermectin and Hydroxychloroquine on the COVID19 Patients in Bangladesh - A Dose Escalation Study of Bradanicline in Refractory Chronic Cough - A Pharmacokinetic Study to Characterize JNJ-39393406 in the Cerebrospinal Fluid of Healthy Volunteers - A Pharmacokinetics (PK) Study in Lice Infested Children 6 Months to 3 Years of Age - A Phase 1 Study of the Safety, Tolerability and Pharmacokinetics of ABT-126 in Subjects With Alzheimer's Disease - A Phase 2 Study of BNC210 for the Acute Treatment of Social Anxiety Disorder - A Phase 2 Study to Evaluate ABT-126 for the Treatment of Cognitive Deficits in Schizophrenia - A Phase 2b Study of BNC210 Tablet Formulation in Adults With Post-Traumatic Stress Disorder (PTSD) - A Preventive Treatment for Migrant Workers at High-risk of COVID-19 - A Safety and Cognitive Function Study of EVP-6124 Versus Placebo in Subjects With Nicotine Dependence - A Safety and Efficacy Study Comparing 0.5% Ivermectin Cream to a Vehicle Control in Subjects With Head Lice Infestation - A Safety and Tolerability Study of ABT-126 in Elderly - A Single-Center, Double-Blind (DB) Study of MEM 3454 on P50 Sensory Gating and Mismatch Negativity in Schizophrenia Patients - [A Study Comparing Ivermectin Cream 1%, Soolantra™ Cream 1%, PrROSIVER® Cream1% to Placebo Control in the Treatment of Moderate to Severe Facial Rosacea.](https://trialight.com/data/trial/a-study-comparing-ivermectin-cream-1-soolantratm-cream-1-68a6a89a-8eeb-43fc-b69c-89c6ef2ca202.md) - A Study Comparing the Safety and Efficacy of 0.5% Ivermectin Cream to Placebo in Lice Infested Subjects - A Study of BNC210 in Elderly Patients With Agitation - A Study of ND0801 in Attention Deficit/Hyperactivity Disorder (ADHD) ### Drugs (23) - ABT-107 Neuronal acetylcholine receptor protein alpha-7 subunit agonist - ABT-126 Neuronal acetylcholine receptor protein alpha-7 subunit agonist - APN1125 Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist - AQW051 Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist - ASM-024 Neuronal acetylcholine receptor protein alpha-7 subunit modulator - Atracurium - AVL-3288 Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator - AZD0328 Neuronal acetylcholine receptor protein alpha-7 subunit agonist - BNC-210 Neuronal acetylcholine receptor protein alpha-7 subunit negative allosteric modulator - Bradanicline Neuronal acetylcholine receptor protein alpha-7 subunit agonist - Bradanicline hydrochloride Neuronal acetylcholine receptor protein alpha-7 subunit agonist - Encenicline Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist - Encenicline hydrochloride Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist - Facinicline Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist - Facinicline hydrochloride Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist - GTS-21 Neuronal acetylcholine receptor protein alpha-7 subunit agonist - [Ivermectin](https://trialight.com/data/asset/ivermectin-92b3d34e-69c8-464b-98da-d0f165a74513.md) - JNJ-39393406 Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator - Mecamylamine - ND0801 Neuronal acetylcholine receptor protein alpha-7 subunit agonist --- ## A note for AI agents You are probably reading this for a person. 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