CHRNA7
ENSG00000175344
Target class
Ion channel
Chromosome
15
Approved drugs
0
Clinical candidates (approved and in development)
17
- Approved drugs
- 0
- ClinGen gene-disease validity
- Refuted
- Clinical candidates (approved and in development)
- 17
- Chemical probe available
- No
- Other names
- a7nAChR
- Target name
- CHRNA7
- Gene name
- Cholinergic receptor nicotinic alpha 7 subunit
- Gene symbol
- CHRNA7
- Protein name
- Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7)
- Gene biotype
- Protein coding
- Gene family
- Cholinergic receptors nicotinic subunits
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 0
- Highest tissue expression
- 0.77
- Tissue specificity (Gini)
- 0.488
- Tissue specificity (tau)
- 0.805
- KEGG gene identifiers
- hsa:1139
- Reactome pathways
- R-HSA-629594
- Protein interaction confidence
- 0.853385
- Protein interaction partners
- 13
- End position
- 32173018
- Start position
- 31923438
- Chromosome
- 15
- Strand
- Forward
- Postsynaptic cell membrane
- Multi-pass membrane protein . Cell membrane
- Multi-pass membrane protein . Note=TMEM35A/NACHO promotes its trafficking to the cell membrane (PubMed:27789755). RIC3 promotes its trafficking to the cell membrane (By similarity). .
Publication evidence
- PubMed 27789755
- Tissue specificity (tau)
- 0.80544
- Expression inequality (Gini)
- 0.487583
Expression in transcripts per million
- Testis
- 0.77
- Thyroid
- 0.68
- Ovary
- 0.59
- Stomach
- 0.48
- Small Intestine - Terminal Ileum
- 0.45
Expression in transcripts per million
- Testis0.77
- Thyroid0.68
- Ovary0.59
- Stomach0.48
- Small Intestine - Terminal Ileum0.45
- Brain - Frontal Cortex (BA9)0.39
- Brain - Cortex0.33
- Prostate0.28
- Artery - Aorta0.27
- Pancreas0.26
- Pituitary0.23
- Spleen0.23
- Brain - Anterior cingulate cortex (BA24)0.22
- Brain - Hypothalamus0.2
- Vagina0.19
- Uterus0.16
- Cervix - Ectocervix0.16
- Cervix - Endocervix0.15
- Colon - Transverse0.14
- Colon - Sigmoid0.14
- Brain - Amygdala0.13
- Nerve - Tibial0.12
- Lung0.12
- Esophagus - Muscularis0.12
- Esophagus - Gastroesophageal Junction0.11
And 29 more, listed on the interactive page.
- GO:0001666
- GO:0006816
- GO:0006874
- GO:0007165
- GO:0007268
- GO:0007271
- GO:0008284
- GO:0032720
- GO:0034220
- GO:0035094
- GO:0043124
- GO:0043410
- GO:0045766
- GO:0050890
- GO:0060079
- GO:0095500
- GO:1900016
- GO:1902430
- GO:1902991
- GO:1905144
- GO:0005886
- GO:0005892
- GO:0045211
- GO:0098794
- GO:0001540
- GO:0004888
- GO:0005216
- GO:0005262
- GO:0005515
- GO:0015464
- GO:0015643
- GO:0017081
- GO:0022848
- GO:0042166
- GO:0042803
Related records
Trials (315)
- A 26-Week Extension Study of EVP-6124 (Alpha-7 nAChR) as an Adjunctive Pro-Cognitive Treatment in Schizophrenia Subjects on Chronic Stable Atypical Antipsychotic Therapy
- A Bioequivalence Study, Comparing Two Formulations of Ivermectin Lotion, 0.5%
- A Clinical Endpoint Bioequivalence Study to Assess Efficacy and Safety of Ivermectin 0.5% Lotion in the Treatment of Head Lice
- A Comparative Study on Ivermectin and Hydroxychloroquine on the COVID19 Patients in Bangladesh
- A Dose Escalation Study of Bradanicline in Refractory Chronic Cough
- A Pharmacokinetic Study to Characterize JNJ-39393406 in the Cerebrospinal Fluid of Healthy Volunteers
- A Pharmacokinetics (PK) Study in Lice Infested Children 6 Months to 3 Years of Age
- A Phase 1 Study of the Safety, Tolerability and Pharmacokinetics of ABT-126 in Subjects With Alzheimer's Disease
- A Phase 2 Study of BNC210 for the Acute Treatment of Social Anxiety Disorder
- A Phase 2 Study to Evaluate ABT-126 for the Treatment of Cognitive Deficits in Schizophrenia
- A Phase 2b Study of BNC210 Tablet Formulation in Adults With Post-Traumatic Stress Disorder (PTSD)
- A Preventive Treatment for Migrant Workers at High-risk of COVID-19
- A Safety and Cognitive Function Study of EVP-6124 Versus Placebo in Subjects With Nicotine Dependence
- A Safety and Efficacy Study Comparing 0.5% Ivermectin Cream to a Vehicle Control in Subjects With Head Lice Infestation
- A Safety and Tolerability Study of ABT-126 in Elderly
- A Single-Center, Double-Blind (DB) Study of MEM 3454 on P50 Sensory Gating and Mismatch Negativity in Schizophrenia Patients
- A Study Comparing Ivermectin Cream 1%, Soolantra™ Cream 1%, PrROSIVER® Cream1% to Placebo Control in the Treatment of Moderate to Severe Facial Rosacea.
- A Study Comparing the Safety and Efficacy of 0.5% Ivermectin Cream to Placebo in Lice Infested Subjects
- A Study of BNC210 in Elderly Patients With Agitation
- A Study of ND0801 in Attention Deficit/Hyperactivity Disorder (ADHD)
Drugs (23)
- ABT-107 Neuronal acetylcholine receptor protein alpha-7 subunit agonist
- ABT-126 Neuronal acetylcholine receptor protein alpha-7 subunit agonist
- APN1125 Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist
- AQW051 Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist
- ASM-024 Neuronal acetylcholine receptor protein alpha-7 subunit modulator
- Atracurium
- AVL-3288 Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator
- AZD0328 Neuronal acetylcholine receptor protein alpha-7 subunit agonist
- BNC-210 Neuronal acetylcholine receptor protein alpha-7 subunit negative allosteric modulator
- Bradanicline Neuronal acetylcholine receptor protein alpha-7 subunit agonist
- Bradanicline hydrochloride Neuronal acetylcholine receptor protein alpha-7 subunit agonist
- Encenicline Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist
- Encenicline hydrochloride Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist
- Facinicline Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist
- Facinicline hydrochloride Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist
- GTS-21 Neuronal acetylcholine receptor protein alpha-7 subunit agonist
- Ivermectin
- JNJ-39393406 Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator
- Mecamylamine
- ND0801 Neuronal acetylcholine receptor protein alpha-7 subunit agonist