> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cftr-1582a227-49f3-5e47-a81a-1acc4b67f420 > Record changed: 2026-10-13 # CFTR ENSG00000001626 Target class Ion channel Chromosome 7 Approved drugs 7 Clinical candidates (approved and in development) 13 ## Clinical evidence **Approved drugs** 7 **Clinical candidates (approved and in development)** 13 ## Druggability **Chemical probe available** Yes ## Names **Target name** CFTR **Gene name** CF transmembrane conductance regulator **Gene symbol** CFTR **Protein name** Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) ### Other names (5) - MRP7 - ABC35 - TNR-CFTR - dJ760C5.1 - CFTR/MRP ### Previous gene symbols (2) - CF - ABCC7 ## Classification **Gene biotype** Protein coding **Gene family** Chloride channels, ATP-gated CFTR|ATP binding cassette subfamily C **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 9 **Highest tissue expression** 65.79 **Tissue specificity (Gini)** 0.898 **Tissue specificity (tau)** 0.986 ## Pathways and interactions **KEGG gene identifiers** - hsa:1080 **Protein interaction confidence** 0.861833 **Protein interaction partners** 72 ### Reactome pathways (11) - R-HSA-382556 - R-HSA-5627083 - R-HSA-5678895 - R-HSA-5689880 - R-HSA-8856825 - R-HSA-8856828 - R-HSA-9013406 - R-HSA-9613829 - R-HSA-9615710 - R-HSA-9646399 - R-HSA-9925563 ## Genomic location **End position** 117715971 **Start position** 117287120 **Chromosome** 7 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000001626 **HGNC ID** HGNC:1884 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1884) **NCBI Gene ID** 1080 **UniProt ID** P13569 ## Cellular location - Apical cell membrane - Multi-pass membrane protein . Early endosome membrane - Multi-pass membrane protein . Cell membrane - Multi-pass membrane protein . Recycling endosome membrane - Multi-pass membrane protein . Endoplasmic reticulum membrane - Multi-pass membrane protein . Nucleus . Note=The channel is internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (PubMed:17462998, PubMed:19398555, PubMed:20008117). In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia (PubMed:22207244). In Sertoli cells, a processed product is detected in the nucleus (By similarity). ER stress induces GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). . ### Publication evidence (29) - PubMed 12519745 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12519745/) - PubMed 12529365 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12529365/) - PubMed 1284548 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1284548/) - PubMed 15247260 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15247260/) - PubMed 15716351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15716351/) - PubMed 17462998 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17462998/) - PubMed 19398555 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19398555/) - PubMed 19621064 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19621064/) - PubMed 20008117 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20008117/) - PubMed 22207244 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22207244/) - PubMed 28130590 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28130590/) - PubMed 10792060 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10792060/) - PubMed 11524016 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11524016/) - PubMed 11707463 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11707463/) - PubMed 12588899 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12588899/) - PubMed 15010471 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15010471/) - PubMed 17036051 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17036051/) - PubMed 1712898 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1712898/) - PubMed 17182731 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17182731/) - PubMed 19019741 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19019741/) - PubMed 21884936 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21884936/) - PubMed 22178883 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22178883/) - PubMed 25330774 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25330774/) - PubMed 26846474 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26846474/) - PubMed 28001373 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28001373/) And 4 more, listed on the interactive page. ## Tissue expression **Tissue specificity (tau)** 0.985812 **Expression inequality (Gini)** 0.898288 ### Highest expression Expression in transcripts per million **Pancreas** 65.79 **Colon - Transverse** 17.32 **Minor Salivary Gland** 9.92 **Small Intestine - Terminal Ileum** 5.06 **Lung** 2.36 ### All tissues (54) Expression in transcripts per million - Pancreas65.79 - Colon - Transverse17.32 - Minor Salivary Gland9.92 - Small Intestine - Terminal Ileum5.06 - Lung2.36 - Skin - Sun Exposed (Lower leg)1.79 - Testis1.7 - Prostate1.5 - Skin - Not Sun Exposed (Suprapubic)1.31 - Brain - Spinal cord (cervical c-1)0.98 - Kidney - Cortex0.96 - Fallopian Tube0.69 - Liver0.56 - Brain - Caudate (basal ganglia)0.42 - Brain - Nucleus accumbens (basal ganglia)0.39 - Brain - Substantia nigra0.39 - Brain - Putamen (basal ganglia)0.34 - Esophagus - Mucosa0.33 - Kidney - Medulla0.32 - Brain - Hippocampus0.27 - Adipose - Visceral (Omentum)0.26 - Pituitary0.19 - Uterus0.19 - Brain - Hypothalamus0.18 - Stomach0.16 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (7) - GO:0015701 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015701) - GO:0034976 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034976) - GO:0035377 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035377) - GO:0050891 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050891) - GO:0055085 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055085) - GO:1902476 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902476) - GO:1904322 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904322) ### Cellular components (15) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005765 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005765) - GO:0005769 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005769) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0010008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0016324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324) - GO:0030660 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030660) - GO:0030669 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030669) - GO:0031901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031901) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) - GO:0055037 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055037) ### Molecular functions (15) - GO:0005254 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005254) - GO:0005260 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005260) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005524 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005524) - GO:0015106 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015106) - GO:0015108 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015108) - GO:0016887 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016887) - GO:0017081 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017081) - GO:0019869 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019869) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0030165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030165) - GO:0042626 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042626) - GO:0051087 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051087) - GO:0071889 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071889) - GO:0106138 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106138) ## Related records ### Trials (145) - (Study: Vertex IIS) Does Ivacaftor Alter Wild Type CFTR-Open Probability In The Sweat Gland Secretory Coil? - A Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Orally Administered SP-303 for the Treatment of Diarrhea in Acquired Immunodeficiency Syndrome (AIDS) Patients - A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects - A Phase 1 Study to Investigate the Food Effect of Lumacaftor in Combination With Ivacaftor - A Phase 2 Study Evaluating Safety and Tolerability of RCT2100 (CFTR mRNA) in Healthy Participants and in Participants With CF - A Phase 2 Study of ABBV-3067 Alone and in Combination With ABBV-2222 - A Phase 2 Study to Evaluate Effects of VX-661/Ivacaftor on Lung and Extrapulmonary Systems in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation - A Phase 2 Study to Evaluate Efficacy and Safety of VX-561 in Subjects Aged 18 Years and Older With Cystic Fibrosis - A Phase 2 Study to Evaluate the Safety, Tolerability, PK and PD in Cystic Fibrosis Patients With at Least 1 G542X Allele - A Phase 2 Study to Evaluate the Safety, Tolerability, PK and PD of ELX-02 in Cystic Fibrosis Patients With G542X Allele - A Phase 3 Rollover Study of Lumacaftor in Combination With Ivacaftor in Subjects 12 Years and Older With Cystic Fibrosis - A Phase 3 Study of Tezacaftor (VX-661) in Combination With Ivacaftor (VX-770) in Subjects Aged 12 Years and Older With Cystic Fibrosis (CF), Who Have One F508del-CFTR Mutation and a Second Mutation That Has Been Demonstrated to be Clinically Responsive to Ivacaftor - A Phase 3 Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Heterozygous for F508del and a Minimal Function Mutation (F/MF) - A Phase 3 Study of VX-445 Combination Therapy in Subjects With Cystic Fibrosis Heterozygous for the F508del Mutation and a Minimal Function Mutation (F/MF) - A Phase 3 Study to Evaluate the Efficacy and Safety of Ivacaftor and VX-661 in Combination With Ivacaftor in Subjects Aged 12 Years and Older With Cystic Fibrosis, Heterozygous for the F508del-cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mutation - A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of VX-661 in Combination With Ivacaftor - A Safety, Tolerability and Efficacy Study With QBW251 in COPD Patients With QBW251 - A Study Evaluating Safety and Pharmacokinetics of VX-440 in Combination With Tezacaftor/Ivacaftor in Healthy Adult Subjects - A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy - A Study Evaluating the Safety and Efficacy of VX-440 Combination Therapy in Subjects With Cystic Fibrosis ### Drugs (13) - Bamocaftor Cystic fibrosis transmembrane conductance regulator positive modulator - Crofelemer Cystic fibrosis transmembrane conductance regulator inhibitor - [Deutivacaftor](https://trialight.com/data/asset/deutivacaftor-a97573e7-c2ce-40af-b8ad-ec03a7b92e34.md) Cystic fibrosis transmembrane conductance regulator activator - Elexacaftor Cystic fibrosis transmembrane conductance regulator positive modulator - Galicaftor Cystic fibrosis transmembrane conductance regulator positive modulator - Icenticaftor Cystic fibrosis transmembrane conductance regulator activator - IOWH-032 Cystic fibrosis transmembrane conductance regulator inhibitor - Ivacaftor Cystic fibrosis transmembrane conductance regulator activator; Cystic fibrosis transmembrane conductance regulator positive modulator - Lumacaftor Cystic fibrosis transmembrane conductance regulator stabiliser - Navocaftor Cystic fibrosis transmembrane conductance regulator positive modulator - Olacaftor Cystic fibrosis transmembrane conductance regulator positive modulator - [Tezacaftor](https://trialight.com/data/asset/tezacaftor-361d103a-bfda-4757-93c8-8092efda7716.md) Cystic fibrosis transmembrane conductance regulator positive modulator - Vanzacaftor Cystic fibrosis transmembrane conductance regulator positive modulator --- ## A note for AI agents You are probably reading this for a person. 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