> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cetp-ee67b070-5298-5ba4-a1fa-ad945dfd4897 > Record changed: 2026-10-13 # CETP ENSG00000087237 Target class Ion channel Chromosome 16 Approved drugs 0 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** Yes ## Names **Other names** - BPIFF **Target name** CETP **Gene name** Cholesteryl ester transfer protein **Gene symbol** CETP **Protein name** Cholesteryl ester transfer protein (Lipid transfer protein I) ## Classification **Gene biotype** Protein coding **Gene family** BPI fold containing **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 14 **Highest tissue expression** 34.97 **Tissue specificity (Gini)** 0.708 **Tissue specificity (tau)** 0.967 ## Pathways and interactions **KEGG gene identifiers** - hsa:1071 **Protein interaction confidence** 0.853814 **Protein interaction partners** 43 ### Reactome pathways (3) - R-HSA-8964041 - R-HSA-8964058 - R-HSA-9029569 ## Genomic location **End position** 56983845 **Start position** 56961923 **Chromosome** 16 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000087237 **HGNC ID** HGNC:1869 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1869) **NCBI Gene ID** 1071 **UniProt ID** P11597 ## Cellular location - Secreted . Note=Secreted in plasma. . ### Publication evidence (2) - PubMed 24293641 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24293641/) - PubMed 3281933 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/3281933/) ## Tissue expression **Tissue specificity (tau)** 0.967098 **Expression inequality (Gini)** 0.708299 ### Highest expression Expression in transcripts per million **Spleen** 34.97 **Thyroid** 7.14 **Adipose - Visceral (Omentum)** 6.59 **Cells - EBV-transformed lymphocytes** 4.95 **Pituitary** 4.08 ### All tissues (54) Expression in transcripts per million - Spleen34.97 - Thyroid7.14 - Adipose - Visceral (Omentum)6.59 - Cells - EBV-transformed lymphocytes4.95 - Pituitary4.08 - Kidney - Medulla3.62 - Breast - Mammary Tissue3.03 - Adipose - Subcutaneous2.95 - Lung2.94 - Kidney - Cortex2.63 - Liver2.35 - Adrenal Gland2.11 - Whole Blood1.24 - Small Intestine - Terminal Ileum1.1 - Artery - Coronary0.97 - Testis0.66 - Prostate0.66 - Uterus0.65 - Cervix - Endocervix0.64 - Cervix - Ectocervix0.55 - Brain - Spinal cord (cervical c-1)0.51 - Brain - Caudate (basal ganglia)0.51 - Artery - Aorta0.5 - Skin - Sun Exposed (Lower leg)0.49 - Brain - Putamen (basal ganglia)0.49 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (18) - GO:0006641 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006641) - GO:0006869 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006869) - GO:0008203 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008203) - GO:0010745 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010745) - GO:0010874 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010874) - GO:0030301 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030301) - GO:0032376 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032376) - GO:0034197 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034197) - GO:0034372 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034372) - GO:0034374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034374) - GO:0034375 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034375) - GO:0042632 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042632) - GO:0043691 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043691) - GO:0046470 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046470) - GO:0055088 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055088) - GO:0055091 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055091) - GO:0070328 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070328) - GO:2001140 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001140) ### Cellular components (4) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0031982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031982) - GO:0034364 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034364) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (6) - GO:0008289 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008289) - GO:0015485 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015485) - GO:0017129 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017129) - GO:0031210 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031210) - GO:0120014 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0120014) - GO:0120020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0120020) ## Related records ### Trials (109) - A CCTA Imaging Trial to Evaluate the Effect of Obicetrapib/Ezetimibe on Coronary Plaque - A Clinical Trial Comparing Torcetrapib/Atorvastatin to Ezetimibe/Simvastatin In Subjects With A Cholesterol Disorder. - A Clinical Trial Comparing Torcetrapib/Atorvastatin To Simvastatin In Subjects With High Cholesterol (A5091031). - A Clinical Trial Comparing Torcetrapib/Atorvastatin To Simvastatin In Subjects With High Cholesterol. - A Coronary IVUS Study to Compare Torcetrapib/Atorvastatin to Atorvastatin Alone in Subjects With Coronary Heart Disease - A Dose-Finding Study in Japanese Patients to Evaluate the Effect of Obicetrapib as an Adjunct to Stable Statin Therapy. - A Drug-drug Interaction Study Evaluating the PK Effects of Obicetrapib on Atorvastatin and Rosuvastatin - A Formulation Screening Study of Dalcetrapib and Atorvastatin in Healthy Volunteers - A Long Term Extension of Study NC19453 Evaluating Safety and Efficacy of RO4607381 - A Preliminary Drug Drug Interaction Study With TA-8995 - A Study Assessing the Effect of RO4607381 on Vascular Function in Patients With Coronary Heart Disease (CHD) or CHD-Risk Equivalent Patients - A Study Comparing The Efficacy & Safety Of Torcetrapib/Atorvastatin And Atorvastatin In Subjects With High Triglycerides - A Study Examining Torcetrapib/Atorvastatin And Atorvastatin Effects On Clinical CV Events In Patients With Heart Disease - A Study of Dalcetrapib in Patients Hospitalized For An Acute Coronary Syndrome (Dal-ACUTE) - A Study of Dalcetrapib in Patients With Stable Coronary Heart Disease, With Coronary Heart Disease Risk Equivalents or at Elevated Risk for Cardiovascular Disease - A Study of Different Particle Sizes of Evacetrapib in Healthy Participants - A Study of Evacetrapib (LY2484595) and Warfarin in Healthy Participants - A Study of Evacetrapib (LY2484595) in Combination With Atorvastatin in Japanese Participants With Primary Hypercholesterolemia - A Study of Evacetrapib (LY2484595) in Healthy Participants - A Study of Evacetrapib (LY2484595) in Japanese Participants With Primary Hypercholesterolemia ### Drugs (6) - Anacetrapib Cholesteryl ester transfer protein inhibitor - [Dalcetrapib](https://trialight.com/data/asset/dalcetrapib-cc01e1b4-85ba-45ed-8edb-c960ab8aa4fb.md) Cholesteryl ester transfer protein inhibitor - Evacetrapib Cholesteryl ester transfer protein inhibitor - [Obicetrapib](https://trialight.com/data/asset/obicetrapib-41ee1f14-bdc7-46e1-adcb-5f53d79c7b97.md) Cholesteryl ester transfer protein inhibitor - Rocacetrapib Cholesteryl ester transfer protein inhibitor - Torcetrapib Cholesteryl ester transfer protein inhibitor --- ## A note for AI agents You are probably reading this for a person. 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