> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cdk6-a48645cb-6daf-5fe9-a635-f8d00b55b425 > Record changed: 2026-10-13 # CDK6 ENSG00000105810 Target class Kinase Chromosome 7 Approved drugs 6 Clinical candidates (approved and in development) 12 ## Clinical evidence **Approved drugs** 6 **Clinical candidates (approved and in development)** 12 ## Druggability **Chemical probe available** Yes ## Names **Other names** - PLSTIRE **Target name** CDK6 **Gene name** Cyclin dependent kinase 6 **Gene symbol** CDK6 **Protein name** Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) ## Classification **Gene biotype** Protein coding **Gene family** Cyclin dependent kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Supported **Highest tissue expression** 32.3 **Tissue specificity (Gini)** 0.363 **Tissue specificity (tau)** 0.83 ## Pathways and interactions **KEGG gene identifiers** - hsa:1021 **Protein interaction confidence** 0.863049 **Protein interaction partners** 61 ### Reactome pathways (9) - R-HSA-2559580 - R-HSA-2559582 - R-HSA-2559585 - R-HSA-69231 - R-HSA-8934593 - R-HSA-9630794 - R-HSA-9632700 - R-HSA-9661069 - R-HSA-9754119 ## Genomic location **End position** 92836591 **Start position** 92604921 **Chromosome** 7 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000105810 **HGNC ID** HGNC:1777 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1777) **NCBI Gene ID** 1021 **UniProt ID** Q00534 ## Cellular location - Cytoplasm. Nucleus. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus. Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (PubMed:23918663). . - Cytosol - Nucleoplasm ### Publication evidence - PubMed 23918663 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23918663/) ## Tissue expression **Tissue specificity (tau)** 0.829937 **Expression inequality (Gini)** 0.363312 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 32.3 **Cells - Cultured fibroblasts** 19.67 **Skin - Not Sun Exposed (Suprapubic)** 11.33 **Skin - Sun Exposed (Lower leg)** 10.28 **Cervix - Ectocervix** 9.84 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes32.3 - Cells - Cultured fibroblasts19.67 - Skin - Not Sun Exposed (Suprapubic)11.33 - Skin - Sun Exposed (Lower leg)10.28 - Cervix - Ectocervix9.84 - Artery - Tibial9.74 - Minor Salivary Gland9.24 - Vagina8.97 - Adrenal Gland8.61 - Artery - Coronary8.36 - Nerve - Tibial8.34 - Cervix - Endocervix8.16 - Artery - Aorta7.71 - Stomach7.68 - Esophagus - Muscularis7.66 - Lung7.52 - Esophagus - Gastroesophageal Junction7.29 - Small Intestine - Terminal Ileum7.25 - Colon - Sigmoid6.45 - Bladder6.37 - Colon - Transverse6.15 - Esophagus - Mucosa5.96 - Adipose - Visceral (Omentum)5.86 - Spleen5.49 - Adipose - Subcutaneous5.37 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (18) - GO:0000082 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000082) - GO:0001954 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001954) - GO:0003323 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003323) - GO:0008285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285) - GO:0009615 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009615) - GO:0010468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010468) - GO:0042063 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042063) - GO:0043697 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043697) - GO:0045596 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045596) - GO:0045638 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045638) - GO:0045646 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045646) - GO:0045656 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045656) - GO:0045668 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045668) - GO:0045786 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045786) - GO:0048146 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048146) - GO:0050680 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050680) - GO:0051726 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051726) - GO:2000773 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000773) ### Cellular components (7) - GO:0000307 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000307) - GO:0001726 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001726) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005813 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005813) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (5) - GO:0004693 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004693) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005524 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005524) - GO:0030332 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030332) - GO:0098770 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098770) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ENZ\_hCDK6, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hCDK6 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (777) - "Neo-Adjuvant Treatment With Palbociclib: Effect on Ki67 and Apoptosis Before, During and After Treatment " - (CLONEVO): Cell cycLe inhbitiON to Target the EVolution of UrOthelial Cancer - (VELA) Study of BLU-222 in Advanced Solid Tumors - \[177Lu\]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer - \[18F\]FLT PET/CT in Rb+ Metastatic Breast Cancer - 7-hydroxystaurosporine and Cisplatin in Treating Patients With Advanced Malignant Solid Tumors - 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) - 7-Hydroxystaurosporine and Perifosine in Treating Patients With Relapsed or Refractory Acute Leukemia, Chronic Myelogenous Leukemia or High Risk Myelodysplastic Syndromes - 7-hydroxystaurosporine and Topotecan Hydrochloride in Treating Patients With Relapsed or Progressed Small Cell Lung Cancer - A Basket Trial of an ERK1/2 Inhibitor (LY3214996) in Combination With Abemaciclib. - A Biomarker Study of Palbociclib + Fulvestrant for Second, and Third Line of Postmenopausal Women With hr+/her2- Advanced Breast Cancer - A Biomarker-driven, Open Label, Single Arm, Multicentre Phase II Study of Abemaciclib in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Who Failed to Platinum-based Therapy - A Clinical Research Study to Determine Whether PD 0332991 May Be Effective in Treating Patients With Liver Cancer - A Clinical Trail to Determine the Safety and Efficacy of the Combination of Tislelizumab With Cisplatin and Gemcitabine, With or Without Trilaciclib for Patients With Untreated Unresectable and Metastatic Urothelial Carcinoma. - A Companion Sample Collection Protocol to Support the Discovery of Breast Cancer Aberrations With Treatment of CDK4/6 Therapy/LEE011/Ribociclib - A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease - A Drug-Drug Interaction Study To Investigate The Potential For Multiple Doses Of Palbociclib (PD-0332991) To Alter The Pharmacokinetics Of Oral Midazolam In Adult Healthy Women of Non-Childbearing Potential. - [A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors](https://trialight.com/data/trial/a-first-in-human-dose-escalation-and-expansion-study-to-e30c8326-67cd-4bf8-80bf-5c8c78451254.md) - A First-in-Human Study of D-0502 Alone and in Combination With Palbociclib in Women With Advanced or Metastatic ER-Positive and HER2-Negative Breast Cancer - A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer ### Drugs (12) - [Abemaciclib](https://trialight.com/data/asset/abemaciclib-602a9f33-bc37-4cf5-8790-5d87472b99d5.md) Cyclin-dependent kinase 6 inhibitor - Alvocidib Cyclin-dependent kinase 6 inhibitor - AT-7519 Cyclin-dependent kinase inhibitor - AZD-5438 Cyclin-dependent kinase inhibitor - [Palbociclib](https://trialight.com/data/asset/palbociclib-2686787c-5f11-4b65-9a5b-549fcd2af644.md) CDK6/cyclin D1 inhibitor - PHA-793887 Cyclin-dependent kinase inhibitor - [Ribociclib](https://trialight.com/data/asset/ribociclib-e1583670-a6ef-48c5-8d6a-4d83f85a626d.md) Cyclin-dependent kinase 6 inhibitor - Ribociclib succinate Cyclin-dependent kinase 6 inhibitor - Roniciclib Cyclin-dependent kinase inhibitor - Trilaciclib Cyclin-dependent kinase 6 inhibitor - Trilaciclib dihydrochloride Cyclin-dependent kinase 6 inhibitor - UCN-01 Cyclin-dependent kinase 6 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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