> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cdk4-7911e947-47b0-5d57-b5c3-76425934201f > Record changed: 2026-10-13 # CDK4 ENSG00000135446 Target class Kinase Chromosome 12 Approved drugs 6 Clinical candidates (approved and in development) 18 ## Clinical evidence **Approved drugs** 6 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 18 ## Druggability **Chemical probe available** Yes ## Names **Other names** - PSK-J3 **Target name** CDK4 **Gene name** Cyclin dependent kinase 4 **Gene symbol** CDK4 **Protein name** Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3) ## Classification **Gene biotype** Protein coding **Gene family** Cyclin dependent kinases|MicroRNA protein coding host genes **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 154.33 **Tissue specificity (Gini)** 0.358 **Tissue specificity (tau)** 0.694 ## Pathways and interactions **KEGG gene identifiers** - hsa:1019 **Protein interaction confidence** 0.835556 **Protein interaction partners** 124 ### Reactome pathways (19) - R-HSA-187577 - R-HSA-2559580 - R-HSA-2559582 - R-HSA-2559585 - R-HSA-3214858 - R-HSA-381340 - R-HSA-69231 - R-HSA-75815 - R-HSA-8849470 - R-HSA-8878166 - R-HSA-912446 - R-HSA-9616222 - R-HSA-9630791 - R-HSA-9630794 - R-HSA-9632697 - R-HSA-9632700 - R-HSA-9661069 - R-HSA-9754119 - R-HSA-9929491 ## Genomic location **End position** 57756013 **Start position** 57747722 **Chromosome** 12 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000135446 **HGNC ID** HGNC:1773 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1773) **NCBI Gene ID** 1019 **UniProt ID** P11802 ## Cellular location - Cytoplasm . Nucleus . Nucleus membrane . Note=Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus. . - Cytosol - Nuclear membrane - Nucleoli - Nucleoplasm ### Publication evidence (3) - PubMed 18827403 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18827403/) - PubMed 20399237 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20399237/) - PubMed 9106657 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9106657/) ## Tissue expression **Tissue specificity (tau)** 0.693597 **Expression inequality (Gini)** 0.358463 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 154.33 **Cells - EBV-transformed lymphocytes** 141.2 **Ovary** 113.27 **Uterus** 107.81 **Cervix - Endocervix** 101 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts154.33 - Cells - EBV-transformed lymphocytes141.2 - Ovary113.27 - Uterus107.81 - Cervix - Endocervix101 - Cervix - Ectocervix97.23 - Fallopian Tube85.15 - Adrenal Gland74.74 - Nerve - Tibial73.93 - Bladder69.41 - Vagina68.11 - Thyroid66.97 - Pituitary66.06 - Breast - Mammary Tissue65.71 - Adipose - Subcutaneous65.39 - Adipose - Visceral (Omentum)63.63 - Artery - Aorta61.88 - Lung60.44 - Artery - Coronary60.3 - Artery - Tibial59.61 - Colon - Sigmoid55.93 - Skin - Sun Exposed (Lower leg)54.28 - Prostate53.25 - Skin - Not Sun Exposed (Suprapubic)52.04 - Esophagus - Gastroesophageal Junction51.36 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0000082 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000082) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0009410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009410) - GO:0010468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010468) - GO:0010971 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010971) - GO:0048146 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048146) - GO:0051726 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051726) - GO:0060260 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060260) ### Cellular components (8) - GO:0000307 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000307) - GO:0000785 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000785) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005730 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005730) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0031965 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031965) ### Molecular functions (5) - GO:0004693 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004693) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016538 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016538) - GO:0030332 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030332) - GO:0106310 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106310) ## Related records ### Trials (796) - "Neo-Adjuvant Treatment With Palbociclib: Effect on Ki67 and Apoptosis Before, During and After Treatment " - (CLONEVO): Cell cycLe inhbitiON to Target the EVolution of UrOthelial Cancer - (VELA) Study of BLU-222 in Advanced Solid Tumors - \[177Lu\]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer - \[18F\]FLT PET/CT in Rb+ Metastatic Breast Cancer - 7-hydroxystaurosporine and Cisplatin in Treating Patients With Advanced Malignant Solid Tumors - 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) - 7-Hydroxystaurosporine and Perifosine in Treating Patients With Relapsed or Refractory Acute Leukemia, Chronic Myelogenous Leukemia or High Risk Myelodysplastic Syndromes - 7-hydroxystaurosporine and Topotecan Hydrochloride in Treating Patients With Relapsed or Progressed Small Cell Lung Cancer - A Basket Trial of an ERK1/2 Inhibitor (LY3214996) in Combination With Abemaciclib. - A Biomarker Study of Palbociclib + Fulvestrant for Second, and Third Line of Postmenopausal Women With hr+/her2- Advanced Breast Cancer - A Biomarker-driven, Open Label, Single Arm, Multicentre Phase II Study of Abemaciclib in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Who Failed to Platinum-based Therapy - A Clinical Research Study to Determine Whether PD 0332991 May Be Effective in Treating Patients With Liver Cancer - A Clinical Trail to Determine the Safety and Efficacy of the Combination of Tislelizumab With Cisplatin and Gemcitabine, With or Without Trilaciclib for Patients With Untreated Unresectable and Metastatic Urothelial Carcinoma. - A Clinical Trial Comparing Gemcitabine and Carboplatin With and Without P276-00 in Subjects With Metastatic Triple Negative Breast Cancer, With a Run-in of Escalating Dose of P276-00 Added to Gemcitabine and Carboplatin - A Companion Sample Collection Protocol to Support the Discovery of Breast Cancer Aberrations With Treatment of CDK4/6 Therapy/LEE011/Ribociclib - A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease - A Drug-Drug Interaction Study To Investigate The Potential For Multiple Doses Of Palbociclib (PD-0332991) To Alter The Pharmacokinetics Of Oral Midazolam In Adult Healthy Women of Non-Childbearing Potential. - [A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors](https://trialight.com/data/trial/a-first-in-human-dose-escalation-and-expansion-study-to-e30c8326-67cd-4bf8-80bf-5c8c78451254.md) - A First-in-Human Study of D-0502 Alone and in Combination With Palbociclib in Women With Advanced or Metastatic ER-Positive and HER2-Negative Breast Cancer ### Drugs (18) - [Abemaciclib](https://trialight.com/data/asset/abemaciclib-602a9f33-bc37-4cf5-8790-5d87472b99d5.md) Cyclin-dependent kinase 4 inhibitor - AG-24322 Cyclin-dependent kinase 4 inhibitor - Alvocidib Cyclin-dependent kinase 4 inhibitor - AT-7519 Cyclin-dependent kinase inhibitor - AZD-5438 Cyclin-dependent kinase inhibitor - Milciclib Cyclin-dependent kinase 4 inhibitor - [Palbociclib](https://trialight.com/data/asset/palbociclib-2686787c-5f11-4b65-9a5b-549fcd2af644.md) Cyclin-dependent kinase 4/cyclin D1 inhibitor - PHA-793887 Cyclin-dependent kinase inhibitor - RG-547 Cyclin-dependent kinase 4 inhibitor - RGB-286638 Cyclin-dependent kinase 4 inhibitor - [Ribociclib](https://trialight.com/data/asset/ribociclib-e1583670-a6ef-48c5-8d6a-4d83f85a626d.md) Cyclin-dependent kinase 4 inhibitor - Ribociclib succinate Cyclin-dependent kinase 4 inhibitor - Riviciclib Cyclin-dependent kinase 4 inhibitor - Roniciclib Cyclin-dependent kinase inhibitor - Trilaciclib Cyclin-dependent kinase 4 inhibitor - Trilaciclib dihydrochloride Cyclin-dependent kinase 4 inhibitor - UCN-01 Cyclin-dependent kinase 4 inhibitor - Voruciclib Cyclin-dependent kinase 4 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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