> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/cdh6-8b0e4988-4b67-5ee2-8800-432e84d051b8
> Record changed: 2026-11-04

# CDH6

ENSG00000113361

Chromosome

5

## Druggability

**Chemical probe available**

No

## Names

**Target name**

CDH6

**Gene name**

Cadherin 6

**Gene symbol**

CDH6

**Protein name**

Cadherin-6 (Kidney cadherin) (K-cadherin)

## Classification

**Gene biotype**

Protein coding

**Gene family**

Type II classical cadherins

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

35

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

16.65

**Tissue specificity (Gini)**

0.51

**Tissue specificity (tau)**

0.862

## Pathways and interactions

**KEGG gene identifiers**

- hsa:1004

**Reactome pathways**

- R-HSA-418990

**Protein interaction confidence**

0.7836

**Protein interaction partners**

15

## Genomic location

**End position**

31329146

**Start position**

31193686

**Chromosome**

5

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000113361

**HGNC ID**

HGNC:1765

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1765)

**NCBI Gene ID**

1004

**UniProt ID**

P55285

## Cellular location

- Cell membrane
- Single-pass type I membrane protein.
- Cell Junctions
- Plasma membrane

## Tissue expression

**Tissue specificity (tau)**

0.861658

**Expression inequality (Gini)**

0.510233

### Highest expression

Expression in transcripts per million

**Artery - Tibial**

16.65

**Nerve - Tibial**

10.44

**Kidney - Cortex**

7.94

**Artery - Coronary**

6.22

**Kidney - Medulla**

5.7

### All tissues (54)

Expression in transcripts per million

- Artery - Tibial16.65
- Nerve - Tibial10.44
- Kidney - Cortex7.94
- Artery - Coronary6.22
- Kidney - Medulla5.7
- Lung5.5
- Cervix - Ectocervix5.25
- Brain - Caudate (basal ganglia)4.75
- Adipose - Subcutaneous4.33
- Brain - Putamen (basal ganglia)3.92
- Adipose - Visceral (Omentum)3.86
- Fallopian Tube3.66
- Cervix - Endocervix3.61
- Thyroid3.25
- Uterus3.17
- Esophagus - Gastroesophageal Junction3.06
- Brain - Hypothalamus2.79
- Brain - Frontal Cortex (BA9)2.75
- Breast - Mammary Tissue2.73
- Bladder2.51
- Brain - Substantia nigra2.47
- Brain - Spinal cord (cervical c-1)2.44
- Brain - Anterior cingulate cortex (BA24)2.32
- Vagina2.3
- Brain - Cortex2.11

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes

- GO:0007155  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007155)

### Cellular components (2)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0030054  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030054)

## Related records

### Trials (5)

- [A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003).](https://trialight.com/data/trial/a-clinical-study-of-raludotatug-deruxtecan-in-people-with-6b1e5a4a-56bb-4891-a239-d464dd0753c5.md)
- A Study of DS-6000a in Subjects With Advanced Renal Cell Carcinoma and Ovarian Tumors
- A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)
- A Study of Raludotatug Deruxtecan (R-DXd) in People With Gastrointestinal Cancers (MK-5909-005)
- [A Study of Raludotatug Deruxtecan in Participants With Advanced/Metastatic Solid Tumors (REJOICE-PanTumor01)](https://trialight.com/data/trial/a-study-of-raludotatug-deruxtecan-in-participants-with-e3c64271-5b3c-4df0-a0de-f3e5009ccdbb.md)

### Drugs (1)

- [Raludotatug deruxtecan](https://trialight.com/data/asset/raludotatug-deruxtecan-6a59b94a-fae6-46e1-a706-898dc8c9d96c.md)

---

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