> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cd80-8456dc75-44f0-5ead-a707-034550215a89 > Record changed: 2026-10-13 # CD80 ENSG00000121594 Target class Surface antigen Chromosome 3 Approved drugs 2 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Target name** CD80 **Gene name** CD80 molecule **Gene symbol** CD80 **Protein name** T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80) ### Other names (2) - B7.1 - B7-1 ### Previous gene symbols (2) - CD28LG - CD28LG1 ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|V-set domain containing|C2-set domain containing|B7 family **Target class** Surface antigen **Target type** Human gene ## Expression and localisation **Tissues expressed in** 3 **Highest tissue expression** 74.27 **Tissue specificity (Gini)** 0.93 **Tissue specificity (tau)** 0.996 ## Pathways and interactions **KEGG gene identifiers** - hsa:941 **Protein interaction confidence** 0.83598 **Protein interaction partners** 99 ### Reactome pathways (8) - R-HSA-1257604 - R-HSA-2219530 - R-HSA-389356 - R-HSA-389357 - R-HSA-389359 - R-HSA-389513 - R-HSA-6783783 - R-HSA-6811558 ## Genomic location **End position** 119569324 **Start position** 119523898 **Chromosome** 3 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000121594 **HGNC ID** HGNC:1700 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1700) **NCBI Gene ID** 941 **UniProt ID** P33681 ## Cellular location - Cell membrane - Single-pass type I membrane protein. ### Publication evidence (2) - PubMed 2794510 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2794510/) - PubMed 38467718 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38467718/) ## Tissue expression **Tissue specificity (tau)** 0.996319 **Expression inequality (Gini)** 0.929502 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 74.27 **Lung** 3.77 **Spleen** 3.3 **Thyroid** 0.82 **Small Intestine - Terminal Ileum** 0.77 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes74.27 - Lung3.77 - Spleen3.3 - Thyroid0.82 - Small Intestine - Terminal Ileum0.77 - Artery - Aorta0.51 - Artery - Coronary0.39 - Kidney - Medulla0.26 - Minor Salivary Gland0.24 - Adipose - Visceral (Omentum)0.23 - Testis0.21 - Adipose - Subcutaneous0.2 - Colon - Transverse0.2 - Nerve - Tibial0.19 - Cervix - Endocervix0.19 - Breast - Mammary Tissue0.19 - Uterus0.17 - Prostate0.17 - Adrenal Gland0.17 - Pituitary0.15 - Pancreas0.15 - Whole Blood0.14 - Artery - Tibial0.14 - Brain - Spinal cord (cervical c-1)0.12 - Esophagus - Mucosa0.12 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0002710 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002710) - GO:0042110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042110) - GO:0050731 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050731) - GO:0050862 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050862) ### Cellular components (3) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0098636 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098636) ### Molecular functions (2) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0048018 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048018) ## Related records ### Trials (492) - A Belatacept Compassionate Use Study for Patients With a Kidney Transplant - A Clinical Research of CAR T Cells Targeting CD19 Positive Malignant B-cell Derived Leukemia and Lymphoma - A Clinical Research of CD22-Targeted CAR-T in B Cell Malignancies - A Clinical Study Exploring CT1194C in Patients With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma - A Clinical Study Exploring Universal CAR-T Cell in Patients With Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia - A Clinical Study on the Safety and Efficacy of CAR-T Therapy for the TM4SF1- and EpCAM-positive Solid Tumors - A Clinical Study on the Safety and Efficacy of CAR-T Therapy for the TM4SF1-positive Tumors of Digestive System - A Clinical Study to Explore CT1194D in Patients With Relapsed/Refractory B-Cell Neoplasms - A Clinical Study to Explore the Safety and Efficacy of CT0991 in Relapsed/Refractory Acute Myeloid Leukemia - A Clinical Study to Explore the Safety and Efficacy of CT1390B in Relapsed/ Refractory Acute Myeloid Leukemia - A Clinical Trial to Evaluate the Efficacy of Abatacept in Moderate to Severe Alopecia Areata - A Cooperative Clinical Study of Abatacept in Multiple Sclerosis - A Dose-ranging Pediatric Study of an Adjuvanted Pandemic Influenza Vaccine - A Novel CAR-T Combined Expression of IL-15 in the Treatment of Malignant Hematological Tumors - A Phase 1/2 Study of CT120 in Patient With Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma - A Phase 3 Study of Abatacept in Chinese Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate - A Phase 3 Study to Compare Upadacitinib to Abatacept in Subjects With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease- Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response or Intolerance to Biologic DMARDs - A Phase I-II Study of High-Dose Post-Transplant Cyclophosphamide, Bortezomib, and Abatacept for the Prevention of Graft-Versus-Host Disease (GVHD) Following Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) - A Phase I/II Study to Evaluate the Safety of Cellular Immunotherapy Using Autologous T Cells Engineered to Express a CD20-Specific Chimeric Antigen Receptor for Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphomas - A Phase II Study of Belatacept (BMS-224818) With a Steroid-free Regimen in Subjects Undergoing Kidney Transplantation ### Drugs (3) - [Abatacept](https://trialight.com/data/asset/abatacept-a318efa4-5922-464c-8f45-90c18515f1c5.md) T-lymphocyte activation antigen CD80 inhibitor - [Belatacept](https://trialight.com/data/asset/belatacept-8e93aa79-7b65-4b31-b315-47488d14be9d.md) T-lymphocyte activation antigen CD80 inhibitor - Galiximab T-lymphocyte activation antigen CD80 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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