CD79B
ENSG00000007312
Target class
Unclassified protein
Chromosome
17
Approved drugs
1
Clinical candidates (approved and in development)
1
- Approved drugs
- 1
- ClinGen gene-disease validity
- Definitive
- Clinical candidates (approved and in development)
- 1
- Chemical probe available
- No
- Target name
- CD79B
- Gene name
- CD79b molecule
- Gene symbol
- CD79B
- Previous gene symbols
- IGB
- Protein name
- B-cell antigen receptor complex-associated protein beta chain (B-cell-specific glycoprotein B29) (Ig-beta) (Immunoglobulin-associated B29 protein) (CD antigen CD79b)
- B29
- Ig-beta
- Igbeta
- Gene biotype
- Protein coding
- Gene family
- CD molecules|V-set domain containing|CD79 molecule family
- Target class
- Unclassified protein
- Target type
- Human gene
- Tissues expressed in
- 39
- Protein localisation evidence grade
- Supported
- Highest tissue expression
- 261.36
- Tissue specificity (Gini)
- 0.784
- Tissue specificity (tau)
- 0.957
- KEGG gene identifiers
- hsa:974
- Protein interaction confidence
- 0.860441
- Protein interaction partners
- 34
- R-HSA-5690714
- R-HSA-9679191
- R-HSA-983695
- End position
- 63932629
- Start position
- 63928738
- Chromosome
- 17
- Strand
- Reverse
- Cell membrane
- Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. .
- Plasma membrane
- Tissue specificity (tau)
- 0.95737
- Expression inequality (Gini)
- 0.784066
Expression in transcripts per million
- Spleen
- 261.36
- Cells - EBV-transformed lymphocytes
- 230.29
- Pituitary
- 53.67
- Whole Blood
- 39.78
- Small Intestine - Terminal Ileum
- 33.81
Expression in transcripts per million
- Spleen261.36
- Cells - EBV-transformed lymphocytes230.29
- Pituitary53.67
- Whole Blood39.78
- Small Intestine - Terminal Ileum33.81
- Cervix - Ectocervix13.19
- Minor Salivary Gland12.69
- Uterus12.62
- Breast - Mammary Tissue12.2
- Adipose - Visceral (Omentum)12.03
- Nerve - Tibial11.6
- Vagina11.13
- Cervix - Endocervix9.92
- Artery - Coronary9.86
- Adipose - Subcutaneous9.59
- Skin - Not Sun Exposed (Suprapubic)8.75
- Bladder8.55
- Fallopian Tube8.54
- Prostate7.57
- Colon - Transverse7.09
- Lung6.34
- Kidney - Medulla5.99
- Esophagus - Muscularis5.49
- Skin - Sun Exposed (Lower leg)5.43
- Heart - Left Ventricle5.37
And 29 more, listed on the interactive page.
- GO:0006955
- GO:0007165
- GO:0005886
- GO:0019815
- GO:0070062
- GO:0071755
- GO:0005515
- GO:0042802
Related records
Trials (191)
- A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
- A Clinical Trial to Assess the Safety, Tolerability and Immunogenicity of MenABCWY in Healthy Infants
- A Multicenter, Retrospective Observational Study to Evaluate the Effectiveness and Safety of Polatuzumab Vedotin
- A Multicentre, Parallel Arm, Open-label Trial of Frontline R-CHOP/Pola-RCHP and Glofitamab in Younger, Higher Risk Patients With Diffuse Large B Cell Lymphoma (DLBCL)
- A Novel Application of 2% Lidocaine Injection for Male Rigid cycstoscopy-a Patient-blinded Randomised Trial
- A Phase Ib/II Study Investigating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With CHOP or CHP-Polatuzumab Vedotin in Participants With B-Cell Non-Hodgkin Lymphoma
- A Phase II Trial of 4 vs 6 Cycles of CHP Combined With Polatuzumab Vedotin-Rituximab in Untreated DLBCL Patients With IPI 0-1
- A Phase II Trial of Mosunetuzumab, Polatuzumab, Tafasitamab, and Lenalidomide in Patients With Relapsed B-cell NHL
- A Preference Study Comparing Kristalose® and Liquid Lactulose
- A Study Comparing the Blood Levels of Both Pegaspargase (S95014) Formulations (Liquid vs Lyophilized) in the Treatment of Paediatric Patients With Acute Lymphoblastic Leukemia (ALL)
- A Study Comparing the Efficacy and Safety of Pola-RCHP-X Versus RCHOP-X and Pola-RCHP in Previously Untreated Patients With DLBCL
- A Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Diffuse Large B-Cell Lymphoma
- A Study Evaluating Efficacy and Safety of Mosunetuzumab in Combination With Polatuzumab Vedotin Compared to Rituximab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed or Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma
- A Study Evaluating Safety and Efficacy of Obinutuzumab, Polatuzumab Vedotin (Pola), and Atezolizumab (Atezo) in Participants With Relapsed or Refractory Follicular Lymphoma (FL) and Rituximab, Atezo, and Pola in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
- A Study Evaluating the Safety, Efficacy and Pharmacokinetics of Venetoclax in Combination With Polatuzumab Vedotin Plus Rituximab (R) and Cyclophosphamide, Doxorubicin, Prednisone (CHP) in Participants With Untreated BCL-2 Immunohistochemistry (IHC)-Positive Diffuse Large B-Cell Lymphoma (DLBCL)
- A Study of BLEX 404 Oral Liquid in Patients With International Prognostic Scoring System (IPSS) Intermediate-1, Intermediate-2 or High-Risk Myelodysplastic Syndrome (MDS) and Chronic Myelomonocytic Leukemia (CMML)
- A Study of Escalating Doses of Polatuzumab Vedotin in Participants With Relapsed or Refractory B-Cell Non-Hodgkins Lymphoma and Chronic Lymphocytic Leukemia and Polatuzumab Vedotin in Combination With Rituximab in Participants With Relapsed or Refractory B-Cell Non-Hodgkins Lymphoma
- A Study of Glofitamab in Combination With Rituximab or Obinutuzumab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP), or Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone (CHP) in Participants With Non-Hodgkin Lymphomas or With DLBCL
- A Study of Obinutuzumab, Polatuzumab Vedotin, and Lenalidomide in Relapsed or Refractory Follicular Lymphoma (FL) and Rituximab in Combination With Polatuzumab Vedotin and Lenalidomide in Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
- A Study of Obinutuzumab, Rituximab, Polatuzumab Vedotin, and Venetoclax in Relapsed or Refractory Follicular Lymphoma (FL) or Diffuse Large B-Cell Lymphoma (DLBCL)
Drugs (1)
- Polatuzumab vedotin B-cell antigen receptor complex-associated protein beta chain binding agent