> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cd3e-b4b887fd-970b-55c2-bf21-d8b729fecbe7 > Record changed: 2026-10-13 # CD3E ENSG00000198851 Target class Membrane receptor Chromosome 11 Approved drugs 11 Clinical candidates (approved and in development) 22 ## Clinical evidence **Approved drugs** 11 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 22 ## Druggability **Chemical probe available** No ## Names **Target name** CD3E **Gene name** CD3 epsilon subunit of T-cell receptor complex **Gene symbol** CD3E **Protein name** T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e) ### Other names (2) - CD3epsilon - CD3-epsilon ## Classification **Gene biotype** Protein coding **Gene family** CD molecules **Target class** Membrane receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 38 **Protein localisation evidence grade** Supported **Highest tissue expression** 103.36 **Tissue specificity (Gini)** 0.755 **Tissue specificity (tau)** 0.942 ## Pathways and interactions **KEGG gene identifiers** - hsa:916 **Protein interaction confidence** 0.812952 **Protein interaction partners** 62 ### Reactome pathways (6) - R-HSA-198933 - R-HSA-202424 - R-HSA-202427 - R-HSA-202430 - R-HSA-202433 - R-HSA-389948 ## Genomic location **End position** 118316175 **Start position** 118304730 **Chromosome** 11 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000198851 **HGNC ID** HGNC:1674 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1674) **NCBI Gene ID** 916 **UniProt ID** P07766 ## Cellular location - Cell membrane - Single-pass type I membrane protein . - Endoplasmic reticulum - Golgi apparatus - Plasma membrane ### Publication evidence (2) - PubMed 10384095 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10384095/) - PubMed 15294938 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15294938/) ## Tissue expression **Tissue specificity (tau)** 0.942314 **Expression inequality (Gini)** 0.754643 ### Highest expression Expression in transcripts per million **Whole Blood** 103.36 **Spleen** 94.82 **Small Intestine - Terminal Ileum** 45.8 **Lung** 23.8 **Colon - Transverse** 9.94 ### All tissues (54) Expression in transcripts per million - Whole Blood103.36 - Spleen94.82 - Small Intestine - Terminal Ileum45.8 - Lung23.8 - Colon - Transverse9.94 - Bladder9.87 - Fallopian Tube8.92 - Stomach8.85 - Adipose - Visceral (Omentum)8.73 - Thyroid7.89 - Vagina7.73 - Cervix - Endocervix7.63 - Prostate7.14 - Esophagus - Mucosa6.01 - Cervix - Ectocervix5.65 - Artery - Coronary4.65 - Minor Salivary Gland4.53 - Adipose - Subcutaneous4.39 - Uterus4.37 - Artery - Aorta4.14 - Breast - Mammary Tissue3.64 - Nerve - Tibial2.97 - Brain - Spinal cord (cervical c-1)2.92 - Skin - Not Sun Exposed (Suprapubic)2.89 - Liver2.7 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0007166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166) - GO:0007169 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007169) - GO:0007172 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007172) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0010629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010629) - GO:0042102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042102) - GO:0050852 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050852) ### Cellular components (4) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009897) - GO:0042101 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042101) - GO:0042105 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042105) ### Molecular functions (6) - GO:0004888 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004888) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0017124 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017124) - GO:0030674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030674) - GO:0032395 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032395) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) ## Related records ### Trials (681) - A 3-cohort Randomized Study Evaluating the Role of New Immunotherapeutic Agents and of Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Frontline Therapy of Adults With Acute Lymphoblastic Leukemia - A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma - A Clinical Trial of MK-1045 in People With B-cell Acute Lymphoblastic Leukemia (MK-1045-005) - A Compassionate Use (CU) Program of Odronextamab - A Dose Escalation Study of Glofitamab (RO7082859) as a Single Agent and in Combination With Obinutuzumab, Administered After a Fixed, Single Pre-treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-cell Non-hodgkin's Lymphoma - A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma - A Longitudinal, Observational Study Comparing Real-World Experiences of Teplizumab-Treated and Untreated Participants With Stage 2 Type 1 Diabetes in the United States - A Multicenter Phase II Trial to Evaluate Rechallenge With Platinum-based Chemotherapy (Carboplatin, Etoposide) for Progression During Tarlatamab Therapy in Relapsed Extensive Disease Small-cell Lung Cancer (SCLC) - A Multicenter, Single-Arm, Open-Label, Phase II Trial of Mosunetuzumab in Combination With Tislelizumab for r/r FL - A Multicentre, Parallel Arm, Open-label Trial of Frontline R-CHOP/Pola-RCHP and Glofitamab in Younger, Higher Risk Patients With Diffuse Large B Cell Lymphoma (DLBCL) - A Open Label, Dose Escalating Study to Evaluate the Safety and Tolerability of Ascending Intravenous (i.v.) Doses of Catumaxomab in Epithelial Cancer Patients - A Phase 1 Study of Vaccination With Dendritic Cell (DC)/Multiple Myeloma (MM) Fusions in Combination With Elranatamab in Relapsed or Refractory Multiple Myeloma - A Phase 1b Open-Label Study Investigating the Safety and Pharmacokinetics of Administration of Subcutaneous Blinatumomab for the Treatment of Relapsed/Refractory Indolent Non-Hodgkin's Lymphoma - A Phase 1b/2 Study to Assess the Safety and Efficacy of Subcutaneous Blinatumomab in Combination With Low Intensity Chemotherapy in Older Patients With Newly Diagnosed B-Cell Acute Lymphoblastic Leukemia - A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases - A Phase 2 Study of Bcl-2 Inhibitor Combined With Azacitidine for Newly Diagnosed Mixed Phenotype Acute Leukemia - A Phase 2 Study of Radiotherapy-induced Immune Priming to Enhance Elranatamab (Elra) in Relapsed Refractory Multiple Myeloma (RRMM) With Extramedullary Disease (EMD) and Paramedullary Disease (PMD) "PRIME-EMD-PMD" - A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC) - A Phase 2 Trial of GlOfitamab anD pIrtobrutinib in Mantle Cell Lymphoma Patients With Prior BTK Inhibitor Exposure. - A Phase 2 Trial of Glofitamab for Minimal Residual Disease in Patients With Large B-cell Lymphoma ### Drugs (22) - Blinatumomab T cell surface glycoprotein CD3 cross-linking agent - Catumaxomab T cell surface glycoprotein CD3 cross-linking agent - [Elranatamab](https://trialight.com/data/asset/elranatamab-43094116-a114-45cf-88c8-60ef9865def2.md) T cell surface glycoprotein CD3 binding agent - [Epcoritamab](https://trialight.com/data/asset/epcoritamab-90c61ada-445b-4582-bc08-34253c4199d1.md) T cell surface glycoprotein CD3 binding agent - Ertumaxomab T-cell surface glycoprotein CD3 epsilon chain cross-linking agent - FBT-A05 T cell surface glycoprotein CD3 cross-linking agent - Flotetuzumab T cell surface glycoprotein CD3 binding agent - Foralumab T cell surface glycoprotein CD3 inhibitor - [Glofitamab](https://trialight.com/data/asset/glofitamab-7a0dacb2-d6fd-4eee-b1db-3e6e7c33c79d.md) T cell surface glycoprotein CD3 binding agent - HOKT3 T-cell surface glycoprotein CD3 epsilon chain inhibitor - MEDI-565 T-cell surface glycoprotein CD3 epsilon chain cross-linking agent - [Mosunetuzumab](https://trialight.com/data/asset/mosunetuzumab-aa4ba629-2b3d-40cc-9deb-ebec509a71eb.md) T cell surface glycoprotein CD3 binding agent - Muromonab-CD3 T cell surface glycoprotein CD3 inhibitor - Odronextamab T cell surface glycoprotein CD3 binding agent - Otelixizumab T-cell surface glycoprotein CD3 epsilon chain binding agent - Resimmune T-cell surface glycoprotein CD3 epsilon chain binding agent - Solitomab T cell surface glycoprotein CD3 cross-linking agent - [Talquetamab](https://trialight.com/data/asset/talquetamab-86adff70-aaf5-413c-b38c-5b76b54aee24.md) T cell surface glycoprotein CD3 binding agent - [Tarlatamab](https://trialight.com/data/asset/tarlatamab-23a11ca8-5d77-4625-92aa-242339e9a92b.md) T cell surface glycoprotein CD3 binding agent - [Teclistamab](https://trialight.com/data/asset/teclistamab-ac78fd73-9c69-450e-bbf3-6207e8be1012.md) T cell surface glycoprotein CD3 binding agent --- ## A note for AI agents You are probably reading this for a person. 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