> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cd38-a5ca1a53-c2f5-5b8e-9449-680140448931 > Record changed: 2026-10-13 # CD38 ENSG00000004468 Target class Enzyme Chromosome 4 Approved drugs 2 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** No ## Names **Other names** - cADPR1 **Target name** CD38 **Gene name** CD38 molecule **Gene symbol** CD38 **Protein name** ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPR hydrolase 1) (T10) (CD antigen CD38) ## Classification **Gene biotype** Protein coding **Gene family** CD molecules **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 43 **Protein localisation evidence grade** Supported **Highest tissue expression** 38.48 **Tissue specificity (Gini)** 0.555 **Tissue specificity (tau)** 0.925 ## Pathways and interactions **KEGG gene identifiers** - hsa:952 **Reactome pathways** - R-HSA-196807 **Protein interaction confidence** 0.833032 **Protein interaction partners** 94 ## Genomic location **End position** 15853232 **Start position** 15778275 **Chromosome** 4 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000004468 **HGNC ID** HGNC:1667 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1667) **NCBI Gene ID** 952 **UniProt ID** P28907 ## Cellular location - Cell surface . Cell membrane - Single-pass type II membrane protein. Note=Localizes in membrane lipid domains. . - Plasma membrane ### Publication evidence (3) - PubMed 2319135 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2319135/) - PubMed 16293598 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16293598/) - PubMed 8253715 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8253715/) ## Tissue expression **Tissue specificity (tau)** 0.925435 **Expression inequality (Gini)** 0.555413 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 38.48 **Spleen** 25.8 **Brain - Caudate (basal ganglia)** 7.29 **Small Intestine - Terminal Ileum** 6.51 **Lung** 6.09 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes38.48 - Spleen25.8 - Brain - Caudate (basal ganglia)7.29 - Small Intestine - Terminal Ileum6.51 - Lung6.09 - Prostate5.74 - Brain - Putamen (basal ganglia)5.38 - Brain - Nucleus accumbens (basal ganglia)4.71 - Artery - Coronary4.63 - Thyroid4.33 - Nerve - Tibial4.04 - Brain - Substantia nigra3.84 - Adipose - Subcutaneous3.84 - Adipose - Visceral (Omentum)3.53 - Pituitary3.52 - Brain - Hypothalamus3.37 - Whole Blood3.2 - Muscle - Skeletal3.11 - Adrenal Gland3.1 - Heart - Atrial Appendage2.98 - Brain - Hippocampus2.82 - Fallopian Tube2.81 - Brain - Anterior cingulate cortex (BA24)2.8 - Brain - Frontal Cortex (BA9)2.51 - Brain - Cortex2.39 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (9) - GO:0009410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009410) - GO:0030890 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030890) - GO:0042110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042110) - GO:0043066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066) - GO:0045892 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045892) - GO:0045893 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045893) - GO:0050853 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050853) - GO:0097190 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097190) - GO:1901847 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1901847) ### Cellular components (4) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (2) - GO:0038023 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038023) - GO:0061809 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061809) ## Off-target safety - regulation of gene expression ### Studies - cell-based: BSK\_SAg\_CD38, is one of 10 assay component(s) measured or calculated from the BSK\_SAg assay. It is designed to make measurements of enzyme-linked immunosorbent assay, a form of binding reporter, as detected with fluorescence intensity signals by Enzyme-linked immunosorbent assay technology. ### Biological samples - umbilical vein endothelium and peripheral blood mononuclear cells, primary cell co-culture Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (588) - "Monoclonal Antibodies for Treatment of Multiple Myeloma. Emphasis on the CD38 Antibody Daratumumab " - 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy - 225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome - 68Ga-DOTATATE PET Scan Imaging in Patients With Neuroendocrine Tumors - A 3-cohort Randomized Study Evaluating the Role of New Immunotherapeutic Agents and of Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Frontline Therapy of Adults With Acute Lymphoblastic Leukemia - A Biomarker-Directed Phase 2 Trial of Tamibarotene (SY-1425) in Participants With Acute Myeloid Leukemia or Myelodysplastic Syndrome - A Clinical Study Assessing the Subcutaneous Formulation of TQB2934 for Injection in Subjects With Malignant Plasma Cell Tumors - A Clinical Study to Evaluate SM17 for Atopic Dermatitis - A Clinical Trail of KJ015 in Patients With HER2-Expressing Solid Tumors - A Clinical Trial of KVA12123 \[TBS-2025\] Treatment Alone and in Combination With Pembrolizumab In Advanced Solid Tumors (VISTA-101) - A Clinical Trial to Assess Safety and Efficacy of Daratumumab in the Treatment of Primary Immune Thrombocytopenia - A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma - A Diagnostic Study of CD38-Targeted ImmunoPET of Myeloma - A Dose Escalation and Cohort Expansion Study of NKTR-214 in Combination With Nivolumab and Other Anti-Cancer Therapies in Patients With Select Advanced Solid Tumors - A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia - A Modular, Phase I/II, Multicentre Study to Evaluate AZD4045, in Participants With Relapsed or Refractory Multiple Myeloma - A Open-Label Phase in Participants With Multiple Myeloma - A Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetics of TAK-079 in Healthy Participants - A Phase 1/2a Study of Human Anti-CD 38 Antibody MOR03087 (MOR202) in Relapsed/Refractory Multiple Myeloma - A Phase 1b Study of WU-NK-101 in Combination With Cetuximab ### Drugs (5) - [Daratumumab](https://trialight.com/data/asset/daratumumab-28c327e5-1741-4dd5-89d4-6562e941ab50.md) Lymphocyte differentiation antigen CD38 inhibitor - Felzartamab Lymphocyte differentiation antigen CD38 inhibitor - Humax-IL15 Lymphocyte differentiation antigen CD38 inhibitor - [Isatuximab](https://trialight.com/data/asset/isatuximab-a4041fba-ee04-4ad4-a6fc-39e24da4aedb.md) Lymphocyte differentiation antigen CD38 inhibitor - Mezagitamab Lymphocyte differentiation antigen CD38 binding agent --- ## A note for AI agents You are probably reading this for a person. 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