> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/cd276-a657d29b-5329-508e-871c-ec52c6bc93ba
> Record changed: 2026-11-04

# CD276

ENSG00000103855

Target class

Surface antigen

Chromosome

15

Approved drugs

0

Clinical candidates (approved and in development)

2

## Clinical evidence

**Approved drugs**

0

**Clinical candidates (approved and in development)**

2

## Druggability

**Chemical probe available**

No

## Names

**Target name**

CD276

**Gene name**

CD276 molecule

**Gene symbol**

CD276

**Protein name**

CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276)

### Other names (3)

- B7-H3
- B7H3
- B7RP-2

## Classification

**Gene biotype**

Protein coding

**Gene family**

CD molecules|V-set domain containing|C2-set domain containing|B7 family

**Target class**

Surface antigen

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

53

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

63.18

**Tissue specificity (Gini)**

0.416

**Tissue specificity (tau)**

0.708

## Pathways and interactions

**KEGG gene identifiers**

- hsa:80381

**Protein interaction confidence**

0.817848

**Protein interaction partners**

33

## Genomic location

**End position**

73714518

**Start position**

73683966

**Chromosome**

15

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000103855

**HGNC ID**

HGNC:19137

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:19137)

**NCBI Gene ID**

80381

**UniProt ID**

Q5ZPR3

## Cellular location

- Membrane
- Single-pass type I membrane protein .
- Vesicles

## Tissue expression

**Tissue specificity (tau)**

0.70772

**Expression inequality (Gini)**

0.416113

### Highest expression

Expression in transcripts per million

**Cells - Cultured fibroblasts**

63.18

**Cervix - Ectocervix**

54.04

**Cervix - Endocervix**

51.38

**Adipose - Subcutaneous**

46.66

**Artery - Aorta**

41.78

### All tissues (54)

Expression in transcripts per million

- Cells - Cultured fibroblasts63.18
- Cervix - Ectocervix54.04
- Cervix - Endocervix51.38
- Adipose - Subcutaneous46.66
- Artery - Aorta41.78
- Artery - Tibial39.69
- Uterus35.64
- Prostate34.15
- Artery - Coronary32.28
- Adrenal Gland32.04
- Ovary30.88
- Bladder30.83
- Skin - Sun Exposed (Lower leg)30.11
- Breast - Mammary Tissue29.85
- Vagina29.14
- Nerve - Tibial26.29
- Lung25.17
- Minor Salivary Gland24.79
- Colon - Sigmoid23.16
- Thyroid22.2
- Skin - Not Sun Exposed (Suprapubic)21.96
- Adipose - Visceral (Omentum)21.73
- Fallopian Tube21.42
- Esophagus - Gastroesophageal Junction19.33
- Esophagus - Muscularis18.29

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (3)

- GO:0032729  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032729)
- GO:0042102  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042102)
- GO:0042110  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042110)

### Molecular functions

- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)

## Related records

### Trials (28)

- [A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)](https://trialight.com/data/trial/a-clinical-study-of-ifinatamab-deruxtecan-i-dxd-in-people-56fce060-49d9-425a-b6b7-c3a1f8ae972e.md)
- [A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)](https://trialight.com/data/trial/a-clinical-study-of-ifinatamab-deruxtecan-based-treatment-99be48a0-44f7-46eb-bdf5-d3d2adc6018e.md)
- A Study in Participants With Advanced Cancers Associated With Expression of DLL3 (MK-6070-001/HPN328-4001)
- A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer (IDeate-Lung03)
- A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)
- A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)
- A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer
- A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)
- [A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)](https://trialight.com/data/trial/a-study-to-evaluate-the-efficacy-and-safety-of-ifinatamab-58f72bf8-725b-412f-ad47-1b5ca7b31919.md)
- [A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab Deruxtecan (I-DXd) in Participants With Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer (MK-6070-002)](https://trialight.com/data/trial/a-study-to-evaluate-the-safety-and-efficacy-of-gocatamig-mk-5be915f2-d817-4d2d-8b0c-6025e0f8141a.md)
- Enoblituzumab (MGA271) in Children With B7-H3-expressing Solid Tumors
- Enoblituzumab Plus MGA012 or MGD013 in Squamous Cell Carcinoma of the Head and Neck
- Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer
- FT516 and IL2 With Enoblituzumab for Ovarian Cancer
- Ifinatamab Deruxtecan (I-DXd) in Subjects With Pretreated Extensive-Stage Small Cell Lung Cancer (ES-SCLC)
- Intraperitoneal RIT With 131I-8H9 for Pts With DSRCT and Other Solid Tumors Involving the Peritoneum
- KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)
- Medical Access Program for Ifinatamab Deruxtecan in 3L+ Pretreated Extensive-stage Small Cell Lung Cancer
- MT2021-27 FT538 Recurrent Ovarian, Fallopian Tube, and Primary Peritoneal Cancer
- Neoadjuvant Enoblituzumab (MGA271) in Men With Localized Intermediate and High-Risk Prostate Cancer

### Drugs (3)

- 8H9 131I CD276 antigen binding agent
- Enoblituzumab CD276 antigen cross-linking agent
- [Ifinatamab deruxtecan](https://trialight.com/data/asset/ifinatamab-deruxtecan-31d740bc-d158-4964-a2dd-567df38e9e3d.md)

---

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