> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cd274-67467e37-9325-584a-be55-e3ef69f22b4c > Record changed: 2026-10-13 # CD274 ENSG00000120217 Target class Unclassified protein Chromosome 9 Approved drugs 5 Clinical candidates (approved and in development) 13 ## Clinical evidence **Approved drugs** 5 **Clinical candidates (approved and in development)** 13 ## Druggability **Chemical probe available** Yes ## Names **Target name** CD274 **Gene name** CD274 molecule **Gene symbol** CD274 **Previous gene symbols** - PDCD1LG1 **Protein name** Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274) ### Other names (5) - B7-H - B7H1 - PD-L1 - PDL1 - B7-H1 ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Receptor ligands|V-set domain containing|C2-set domain containing|B7 family **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 46 **Protein localisation evidence grade** Supported **Highest tissue expression** 59.8 **Tissue specificity (Gini)** 0.584 **Tissue specificity (tau)** 0.954 ## Pathways and interactions **KEGG gene identifiers** - hsa:29126 **Protein interaction confidence** 0.814574 **Protein interaction partners** 94 ### Reactome pathways (7) - R-HSA-389948 - R-HSA-9701898 - R-HSA-9909620 - R-HSA-9929356 - R-HSA-9929491 - R-HSA-9931269 - R-HSA-9931295 ## Genomic location **End position** 5470566 **Start position** 5450503 **Chromosome** 9 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000120217 **HGNC ID** HGNC:17635 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:17635) **NCBI Gene ID** 29126 **UniProt ID** Q9NZQ7 ## Cellular location - Cell membrane - Single-pass type I membrane protein . Early endosome membrane - Single-pass type I membrane protein . Recycling endosome membrane - Single-pass type I membrane protein . Nucleus . Note=Associates with CMTM6 at recycling endosomes, where it is protected from being targeted for lysosomal degradation (PubMed:28813417). Translocates to the nucleus in response to hypoxia via its interaction with phosphorylated STAT3 (PubMed:32929201). . - SUBCELLULAR LOCATION: \[Isoform 1\]: Cell membrane - Single-pass type I membrane protein . - SUBCELLULAR LOCATION: \[Isoform 2\]: Endomembrane system - Single-pass type I membrane protein . - SUBCELLULAR LOCATION: \[Isoform 4\]: Secreted . - Nuclear speckles - Nucleoplasm - Plasma membrane ### Publication evidence (6) - PubMed 28813410 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28813410/) - PubMed 28813417 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28813417/) - PubMed 36232715 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36232715/) - PubMed 32929201 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32929201/) - PubMed 15780196 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15780196/) - PubMed 30564891 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30564891/) ## Tissue expression **Tissue specificity (tau)** 0.95371 **Expression inequality (Gini)** 0.584431 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 59.8 **Lung** 24.56 **Spleen** 15 **Artery - Aorta** 5.11 **Pituitary** 4.81 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes59.8 - Lung24.56 - Spleen15 - Artery - Aorta5.11 - Pituitary4.81 - Heart - Left Ventricle4.77 - Thyroid4.68 - Heart - Atrial Appendage4.19 - Cervix - Ectocervix3.53 - Adipose - Visceral (Omentum)3.4 - Cervix - Endocervix3.29 - Artery - Coronary3.19 - Fallopian Tube3.18 - Whole Blood3.1 - Adipose - Subcutaneous3.08 - Uterus3.04 - Small Intestine - Terminal Ileum2.65 - Nerve - Tibial2.56 - Breast - Mammary Tissue2.37 - Vagina2.35 - Esophagus - Mucosa2.31 - Brain - Hypothalamus2.27 - Kidney - Medulla2.24 - Prostate2.23 - Ovary2.2 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (21) - GO:0002841 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002841) - GO:0006955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006955) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166) - GO:0031295 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031295) - GO:0032689 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032689) - GO:0032693 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032693) - GO:0032733 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032733) - GO:0034097 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034097) - GO:0035666 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035666) - GO:0042102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042102) - GO:0046006 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046006) - GO:0046007 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046007) - GO:0050860 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050860) - GO:0050868 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050868) - GO:0070232 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070232) - GO:1903556 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903556) - GO:1905399 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905399) - GO:1905404 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905404) - GO:2000562 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000562) - GO:2001186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001186) ### Cellular components (12) - GO:0000139 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000139) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0012505 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0012505) - GO:0016607 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016607) - GO:0031901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031901) - GO:0055038 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055038) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (3) - GO:0003713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003713) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0048018 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048018) ## Related records ### Trials (2,566) - --SuPERIOR Trial-- - ......SMARTEST Trial...... - "neoBREASTIM": Atezolizumab Plus RP1 Oncolytic Immunotherapy in the NeoAdjuvant Setting of Triple-Negative Breast Cancer - 1st Line Durvalumab in PS 2 NSCLC Patients - 89Zr-labeled KN035 PET Imaging in Patients With PD-L1 Positive Solid Tumors - A Clinical Study Based on FAPI-PET/CT Technology to Predict Pathological Complete Response After Neoadjuvant Chemoradiotherapy for MSS Rectal Cancer - A Clinical Study of Adebrelimab Combined With Apatinib and Paclitaxel in Patients With Advanced Gastric Cancer. - A Clinical Study of Adebrelimab in Combination With SHR-8068 and Chemoradiotherapy as Perioperative Therapy for Locally Advanced Rectal Cancer - A Clinical Study of Cobimetinib Administered in Combination With Niraparib, With or Without Atezolizumab to Patients With Advanced Platinum-sensitive Ovarian Cancer - A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003) - A Clinical Study of IMC-001 for Injection in Improving Atherosclerotic Plaque Stability in Patients With Acute Coronary Syndrome. - A Clinical Study of Immunotherapy Combined With Chemotherapy and Anti-angiogenic Therapy in Operable NSCLC - A Clinical Study of PD-L1 Antibody ZKAB001 Combined With Capecitabine in Resected Biliary Tract Cancer - A Clinical Study of PD-L1 Antibody ZKAB001(Drug Code) in Limited Stage of High-grade Osteosarcoma - A Clinical Study of PD-L1 Antibody ZKAB001（Drug Code） in Locally Advanced and Metastatic Urothelial Carcinoma - A Clinical Study of PD-L1 Antibody ZKAB001（Drug Code） in Recurrent or Metastatic Cervical Cancer - A Clinical Study of QL1706 Combined With Chemotherapy as Neoadjuvant Therapy for High-Risk Locally Advanced Cervical Cancer - A Clinical Study of Recombinant Human Vascular Endothelial Inhibitor in Combination With PRaG for Advanced Refractory Non-small Cell Lung Cancer - A Clinical Study of SHR-1316 (SC) Combined With Carboplatin and Etoposide as First-line Treatment for Extensive Stage Small Cell Lung Cancer - A Clinical Study of SHR-8068 Combined With Adebrelimab and Bevacizumab Versus Sintilimab or Atezolizumab Combined With Bevacizumab for the Treatment of Advanced Hepatocellular Carcinoma ### Drugs (13) - [Adebrelimab](https://trialight.com/data/asset/adebrelimab-047820dd-1777-483d-90ab-dd5fc86f78f6.md) Programmed cell death 1 ligand 1 inhibitor - [Atezolizumab](https://trialight.com/data/asset/atezolizumab-2cce6944-73b7-49f4-8125-4e6747997b82.md) Programmed cell death 1 ligand 1 inhibitor - [Avelumab](https://trialight.com/data/asset/avelumab-7197343d-e77c-45d7-978a-ad6cf91f6437.md) Programmed cell death 1 ligand 1 other - Bintrafusp alfa Programmed cell death 1 ligand 1 binding agent - Cosibelimab Programmed cell death 1 ligand 1 inhibitor - Danburstotug Programmed cell death 1 ligand 1 inhibitor - [Durvalumab](https://trialight.com/data/asset/durvalumab-bca7c265-7862-46e1-bf29-3dd2fdda4954.md) Programmed cell death 1 ligand 1 inhibitor - [Envafolimab](https://trialight.com/data/asset/envafolimab-067ce798-3523-4c36-9d89-3452238113d3.md) Programmed cell death 1 ligand 1 binding agent - Erfonrilimab Programmed cell death 1 ligand 1 inhibitor - INCB-086550 Programmed cell death 1 ligand 1 inhibitor - Pacmilimab Programmed cell death 1 ligand 1 binding agent - Socazolimab Programmed cell death 1 ligand 1 inhibitor - Sugemalimab Programmed cell death 1 ligand 1 binding agent --- ## A note for AI agents You are probably reading this for a person. 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